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|Antigen||Discoidin Domain Receptor Family, Member 1 (DDR1) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This MCK10 antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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Product Details anti-MCK10 AntibodyTarget Details MCK10 Application Details Handling Images
|Specificity||This antibody detects Discoidin Domain Receptor (DDR1), N-terminal region.|
|Immunogen||DDR1 antibody was raised against synthetic peptide from N-terminal region of human DDR1.|
Target Details MCK10Product Details anti-MCK10 Antibody Application Details Handling Images back to top
|Alternative Name||CD167a / DDR1 (DDR1 Antibody Abstract)|
|Background||DDR1 is a DDR/TKT type protein kinase. DDR1 is activated by various types of collagen, including types I through IV. Binding of collagen to DDR1 protein results in autophosphorylation and a delayed but sustained tyrosine kinase activation. DDR1 may function in cell-to-cell interaction or recognition. At least three mRNA variants, resulting in different protein isoforms of 875, 913 and 919 amino acids, have been reported. DDR1 protein has been shown to be over expressed in human breast, ovarian, esophageal and pediatric brain tumors.Synonyms: CAK, CD167 antigen-like family member A, EDDR1, Epithelial discoidin domain receptor 1, Epithelial discoidin domain-containing receptor 1, MCK10, NEP, NTRK4, PTK3A, RTK6, TRKE, Tyrosine kinase DDR-1|
|Pathways||RTK Signaling, Smooth Muscle Cell Migration|
Application DetailsProduct Details anti-MCK10 Antibody Target Details MCK10 Handling Images back to top
Immunohistochemistry on paraffin section(17 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MCK10 Antibody Target Details MCK10 Application Details Images back to top
|Buffer||PBS containing 0.09 % sodium azide as preservative|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.|