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DDR1 kinase activity is required for regulating collagen IV (show COL4 Proteins) synthesis.
DDR-1 interacts with the TGF-beta (show TGFB1 Proteins) pathway to restrict calcifying extracellular vesicle-mediated mineralization and fibrosis by smooth muscle cells.
alpha5(IV), but not alpha1(IV), promotes lung cancer cell proliferation and tumor angiogenesis through non-integrin collagen receptor (show ITGA2 Proteins) DDR1-mediated ERK (show EPHB2 Proteins) activation.
DDR1 malfunction causes outer hair cells deformation and the separation of the lateral wall, the location of the cellular motor responsible for the electromotile property, explicitly in those regions showing DDR1 and NM-IIA co-localization.
the collagen receptors DDR1 and integrin a2b1 contribute to regulate GBM-maturation and to control matrix accumulation.
Extensive co-localization and relationship of Jag1 (show JAG1 Proteins) and Ddr1 in bile ducts and blood vessels in postnatal liver.
Genetic inhibition of discoidin domain receptor 1 protects mice against crescentic glomerulonephritis.
Data identifyies Syk (show SYK Proteins) as a potent inhibitor of epithelial migration and describes a first functional consequence of the interaction with the collagen receptor (show ITGA2 Proteins) DDR1.
Results show that DDR1 promotes cell-cell adhesion and differentiation through stabilization of E-cadherin (show CDH1 Proteins), which is mediated by Cdc42 (show CDC42 Proteins) inactivation.
Collagen I stimulates the self-renewal of embryonic stem cells mediated by Bmi-1 (show BMI1 Proteins) through alpha2beta1 integrin-dependent ILK (show ILK Proteins), Notch (show NOTCH1 Proteins), Gli-1 (show GLI1 Proteins), and DDR1-dependent Ras, PI3K/Akt (show AKT1 Proteins), and ERK (show EPHB2 Proteins).
Data suggest that IGF-I (show IGF1 Proteins)/IGF-IR system triggers stimulatory actions through both GPER and DDR1 in aggressive tumors as mesothelioma and lung tumors.
we further analyzed the CpG methylation levels at the DDR1 promoter in EOC cells and found that the CpG methylation levels of DDR1 promoter correlated negatively with the expression of DDR1 along the EMT (show ITK Proteins) spectrum. Therefore, EMT (show ITK Proteins) stratification could be a potential biomarker to predict patient response to DDR1-targeting drugs.
This study suggested that DDR1 and DDR2 (show DDR2 Proteins) knockdown alters brain immunity and significantly reduces the level of triggering receptor expressed on myeloid cells (TREM)-2 (show TREM2 Proteins) and microglia.
Isoform b of DDR1 is responsible for collagen I-induced up-regulation of N-cadherin (show CDH2 Proteins) and tyrosine 513 of DDR1b is necessary.
Reduced DDR1 expression may be implicated in impaired melanocyte adhesion process involved in vitiligo (show MITF Proteins) pathogenesis
data demonstrate that TGF-beta1 (show TGFB1 Proteins) favors linear invadosome formation through the expressions of both the inducers, such as collagen and LOXL2 (show LOXL2 Proteins), and the components such as DDR1 and MT1-MMP (show MMP14 Proteins) of linear invadosomes in cancer cells. Meanwhile, our data uncover a new TGF-beta1 (show TGFB1 Proteins)-dependent regulation of DDR1 expression.
DDR1 overexpression promoted GC cell proliferation (p < 0.05), migration (p < 0.01), and invasion (p < 0.01), and accelerated the growth (p < 0.05) as well as the microvessel formation (p < 0.01) of transplantation tumor in nude mice.
Our results suggest that DDR1 is both a prognostic marker for renal clear cell carcinoma and a potential functional target for therapy
Study concludes that non-canonical DDR1 signaling enables breast cancer cells to exploit the ubiquitous interstitial matrix component collagen I to undergo metastatic reactivation in multiple target organs.
Upregulation of DDR1 collagen receptor (show ITGA2 Proteins) is associated with breast cancer.
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
discoidin domain receptor family, member 1
, discoidin domain receptor tyrosine kinase 1
, epithelial discoidin domain-containing receptor 1
, CD167 antigen-like family member A
, cell adhesion kinase
, discoidin receptor tyrosine kinase
, epithelial discoidin domain receptor 1
, protein-tyrosine kinase MPK-6
, tyrosine kinase DDR
, tyrosine-protein kinase CAK
, PTK3A protein tyrosine kinase 3A
, mammary carcinoma kinase 10
, neuroepithelial tyrosine kinase
, neurotrophic tyrosine kinase, receptor, type 4
, protein-tyrosine kinase RTK-6
, neurotrophic tyrosine kinase receptor type 4
, protein-tyrosine kinase 3
, protein-tyrosine kinase PTK-3