General
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Antigen
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Membrane Metallo-Endopeptidase (MME) Antibodies
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Reactivity
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Cat (Feline), Dog (Canine), Human
Alternatives
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Host
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Mouse
Alternatives
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Clonality (Clone)
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Conjugate
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This MME antibody is un-conjugated
Alternatives
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Application
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Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Alternatives
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Supplier
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Log in to see
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Purification
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Protein G affinity chromatography
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Immunogen
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A recombinant human protein was used as the immunogen for the CD10 antibody.
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Clone
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MME-1698
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Isotype
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Kappa, IgG1
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Antigen
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Alternative Name
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CD10 / Neprilysin (MME Antibody Abstract)
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Background
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CD10, also known as Common Acute Lymphocytic Leukemia Antigen (CALLA) and Neprilysin, is a cell surface enzyme with neutral metalloendopeptidase activity, which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt's, and follicular germinal center lymphomas, and on cells from patients with chronic myelocytic leukemia (CML). It is also expressed on the surface of normal early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue. CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells.
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Pathways
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RTK Signaling, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration
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Application Notes
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Optimal dilution of the CD10 antibody should be determined by the researcher.\. Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 1-2 μg/mL, IHC (FFPE): 1-2 μg/mL
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Restrictions
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For Research Use only
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Buffer
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0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
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Preservative
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Sodium azide
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Precaution of Use
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This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
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4 °C,-20 °C
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Storage Comment
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Store the CD10 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
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