We are preparing the requested document. Please wait, this may take a while...!
|Antigen||Membrane Metallo-Endopeptidase (MME) Antibodies|
|Conjugate||This MME antibody is conjugated to FITC Alternatives|
Flow Cytometry (FACS), Immunoprecipitation (IP)
|4 references available|
|Supplier||Log in to see|
Product Details anti-MME AntibodyTarget Details MME Application Details Handling References for anti-MME antibody (ABIN93932) Images
The antibody MEM-78 reacts with CD10 antigen (CALLA - Common acute lymphatic leukemia antigen), a 100 kDa type II integral membrane protein.
HLDA IV, WS Code B 506
HLDA V, WS Code B CD10.4
|Immunogen||NALM-6 human pre-B cell line|
|Plasmids, Primers & others|
Target Details MMEProduct Details anti-MME Antibody Application Details Handling References for anti-MME antibody (ABIN93932) Images back to top
|Alternative Name||CD10 (MME Antibody Abstract)|
|Background||CD10 (neutral endopeptidase –, NEP, common acute lymphocytic leukemia antigen –, CALLA, membrane metallo-endopeptidase –, MME, enkefalinase) is a 100- kDa cell surface zinc metalloprotease cleaving peptide bonds on the N-terminus of hydrophobic amino acids and inactivating multiple physiologically active peptids. CD10 is expressed on various normal cell types, including lymphoid precursor cells, germinal center B lymhocytes, and some epithelial cells, and its expression level serves as a marker for diagnostics of many carcinomas. CD10 is also a differentiation antigen for early B-lymphoid progenitors in the B-cell differentiation pathway and has a key role in regulation of growth, differentiation and signal transduction of many cellular systems.|
|Pathways||RTK Signaling, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration|
Application DetailsProduct Details anti-MME Antibody Target Details MME Handling References for anti-MME antibody (ABIN93932) Images back to top
|Application Notes||The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μ,l reagent / 100 μ,l of whole blood or 106 cells in a suspension.The content of a vial (2 ml) is sufficient for 100 tests.|
The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MME Antibody Target Details MME Application Details References for anti-MME antibody (ABIN93932) Images back to top
|Reconstitution||No reconstitution is necessary.|
|Buffer||The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
Do not freeze.
Avoid prolonged exposure to light.
|Storage Comment||Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.|
References for anti-MME antibody (ABIN93932)Product Details anti-MME Antibody Target Details MME Application Details Handling Images back to top
DallEra, True, Siegel, Porter, Sherertz, Liu: "Differential expression of CD10 in prostate cancer and its clinical implication." in: BMC urology, Vol. 7, pp. 3, 2007
Braham, Trimeche, Ziadi, Mestiri, Mokni, Amara, Hachana, Sriha, Korbi: "CD10 expression by fusiform stromal cells in nasopharyngeal carcinoma correlates with tumor progression." in: Virchows Archiv : an international journal of pathology, Vol. 449, Issue 2, pp. 220-4, 2006
Yada, Kashima, Daa, Kitano, Fujiwara, Yokoyama: "Expression of CD10 in basal cell carcinoma." in: The American Journal of dermatopathology, Vol. 26, Issue 6, pp. 463-71, 2004
|Product cited in:||
Angelisová, Drbal, Horejsí, Cerný: "Association of CD10/neutral endopeptidase 24.11 with membrane microdomains rich in glycosylphosphatidylinositol-anchored proteins and Lyn kinase." in: Blood, Vol. 93, Issue 4, pp. 1437-9, 1999
ImagesProduct Details anti-MME Antibody Target Details MME Application Details Handling References for anti-MME antibody (ABIN93932) back to top