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This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464).
, MST1R variant RON30
, MST1R variant RON62
, PTK8 protein tyrosine kinase 8
, RON variant 21
, RON variant E2E3
, c-met-related tyrosine kinase
, macrophage-stimulating protein receptor
, soluble RON variant 1
, soluble RON variant 2
, soluble RON variant 3
, soluble RON variant 4
, friend virus susceptibility 2
, macrophage-stimulating protein receptor precursor (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase)
, receptor protein tyrosine kinase, c-met-related
, stem cell-derived tyrosine kinase
, protein tyrosine kinase 8
, tyrosine kinase receptor ron