anti-Mouse (Murine) MUSK antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended MUSK Antibody (supplied by: Log in to see )

Antigen
Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) Antibodies
  • unp
  • fj98e12
  • zgc:63467
  • wu:fj98e12
  • si:dz46m7.2
  • si:dz57f23.3
  • si:busm1-57f23.3
  • musk-A
  • MuSK
  • MUSK
  • Mdk4
  • Mlk
  • Nsk1
  • Nsk2
  • Nsk3
  • muscle
  • muscle associated receptor tyrosine kinase
  • muscle, skeletal, receptor tyrosine kinase
  • muscle associated receptor tyrosine kinase S homeolog
  • MUSK
  • musk
  • musk.S
  • Musk
Reactivity
Mouse (Murine), Rat (Rattus)
129
60
50
2
2
2
1
1
1
1
Host
Mouse
109
30
3
Clonality
Monoclonal
Conjugate
This MUSK antibody is un-conjugated
6
6
5
4
4
4
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
112
78
71
31
26
13
12
8
6
5
4
1
1
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Catalog No. ABIN4912113
$ 204.49
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
7 ABIN5584015 IHC (p) WB Mouse IgG1 kappa Log in to see 1429CT456-173-44 0
4 ABIN1386240 IF (p) IHC (p) WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN1415367 IHC (p) WB HRP Rabbit IgG Log in to see Polyclonal 0
1 ABIN1397493 IHC (p) WB Biotin Rabbit IgG Log in to see Polyclonal 0
1 ABIN2743079 ELISA IHC IHC (p) WB Mouse IgG1, kappa Log in to see 1429CT456-173-44 0
1 ABIN6242455 IHC (p) WB Mouse IgG1, kappa Log in to see 1429CT456-173-44 0

General

Antigen Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) Antibodies
Reactivity Mouse (Murine), Rat (Rattus)
(129), (60), (50), (2), (2), (2), (1), (1), (1), (1)
Host Mouse
(109), (30), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This MUSK antibody is un-conjugated
(6), (6), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(112), (78), (71), (31), (26), (13), (12), (8), (6), (5), (4), (1), (1)
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Product Details anti-MUSK Antibody

Target Details MUSK Application Details Handling Images
Purification Purified by Protein G.
Immunogen This mouse Musk antibody is generated from a mouse immunized with recombinant protein from mouse Musk.
Clone 1429CT456-173-44
Isotype IgG1 kappa
Plasmids, Primers & others

Target Details MUSK

Product Details anti-MUSK Antibody Application Details Handling Images back to top
Antigen
Alternative Name Musk (MUSK Antibody Abstract)
Background

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation.

Synonyms: Mlk, Mdk4, Nsk1, Nsk2, Nsk3, Muscle, skeletal receptor tyrosine-protein kinase, Muscle-specific tyrosine-protein kinase receptor, MuSK, Muscle-specific kinase receptor

Gene ID 18198
UniProt Q61006
Pathways RTK Signaling, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development

Application Details

Product Details anti-MUSK Antibody Target Details MUSK Handling Images back to top
Application Notes WB 1:500-1000
IHC-P 1:25
Restrictions For Research Use only

Handling

Product Details anti-MUSK Antibody Target Details MUSK Application Details Images back to top
Storage 4 °C,-20 °C
Storage Comment Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Images

Product Details anti-MUSK Antibody Target Details MUSK Application Details Handling back to top
Supplier Images
Western Blotting (WB) image for anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) antibody (ABIN4912113) Lane 1: Mouse C2C12 Cell Lysates, Lane 2: Rat L6 Cell Lysates, probed with Musk (1429...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) antibody (ABIN4912113) Paraformaldehyde-fixed, paraffin embedded mouse skeletal muscle tissue, Antigen retri...