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|Antigen||Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1) Antibodies|
|Epitope||AA 29-181 Alternatives|
|Reactivity||Dog (Canine), Human Alternatives|
|Conjugate||This NFAT1 antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-NFAT1 AntibodyTarget Details NFAT1 Application Details Handling References for anti-NFAT1 antibody (ABIN968124) Images
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Immunogen||Human NFAT-1 aa. 29-181|
Target Details NFAT1Product Details anti-NFAT1 Antibody Application Details Handling References for anti-NFAT1 antibody (ABIN968124) Images back to top
|Alternative Name||NFAT-1 (NFAT1 Antibody Abstract)|
T cells are activated and induced to proliferate following binding of their respective antigen. The process of includes expression of genes that encode factors (i.e., cytokines) which regulate various cell types. Modulation of gene expression is conducted by an array of specific interactions between transcription factors and DNA. NFAT-1 (Nuclear Factor of Activated T cells) is a transcription factor that regulates expression of the interleukin-2 gene. Thus, NFAT-1 DNA binding activity is undetectable in resting cells, but increases during T-cell activation. NFAT-1, a protein of 921 amino acids, is part of an oligomeric transcription factor that also contains Fra-1 and JunB. NFAT-1 was initially described as a phosphoprotein and is dephosphorylated in activated T cells transformed with the leukemia virus HTLV-l.
Synonyms: NF-ATc2, NFATP, KIAA0611
|Molecular Weight||97-135 kDa|
|Pathways||RTK Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, VEGF Signaling|
Application DetailsProduct Details anti-NFAT1 Antibody Target Details NFAT1 Handling References for anti-NFAT1 antibody (ABIN968124) Images back to top
Related Products: ABIN968537, ABIN968619, ABIN967389
|Restrictions||For Research Use only|
HandlingProduct Details anti-NFAT1 Antibody Target Details NFAT1 Application Details References for anti-NFAT1 antibody (ABIN968124) Images back to top
|Buffer||Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at -20°C.|
References for anti-NFAT1 antibody (ABIN968124)Product Details anti-NFAT1 Antibody Target Details NFAT1 Application Details Handling Images back to top
|Product cited in:||
Grader-Beck, van Puijenbroek, Nadler, Boussiotis: "cAMP inhibits both Ras and Rap1 activation in primary human T lymphocytes, but only Ras inhibition correlates with blockade of cell cycle progression." in: Blood, Vol. 101, Issue 3, pp. 998-1006, 2003
Kadereit, Mohammad, Miller, Woods, Listrom, McKinnon, Alali, Bos, Iacobucci, Sramkoski, Jacobberger, Laughlin: "Reduced NFAT1 protein expression in human umbilical cord blood T lymphocytes." in: Blood, Vol. 94, Issue 9, pp. 3101-7, 1999
Good, Maggirwar, Harhaj, Sun: "Constitutive dephosphorylation and activation of a member of the nuclear factor of activated T cells, NF-AT1, in Tax-expressing and type I human T-cell leukemia virus-infected human T cells." in: The Journal of biological chemistry, Vol. 272, Issue 3, pp. 1425-8, 1997
Boise, Petryniak, Mao, June, Wang, Lindsten, Bravo, Kovary, Leiden, Thompson: "The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB." in: Molecular and cellular biology, Vol. 13, Issue 3, pp. 1911-9, 1993
McCaffrey, Luo, Kerppola, Jain, Badalian, Ho, Burgeon, Lane, Lambert, Curran: "Isolation of the cyclosporin-sensitive T cell transcription factor NFATp." in: Science (New York, N.Y.), Vol. 262, Issue 5134, pp. 750-4, 1993
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