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|Antigen||Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1) Antibodies|
|Epitope||AA 589-652 Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This NFATC1 antibody is un-conjugated Alternatives|
ELISA, Western Blotting (WB)
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Product Details anti-NFATC1 AntibodyTarget Details NFATC1 Application Details Handling Images
|Purpose||Rabbit IgG polyclonal antibody for NFAT2 detection. Tested with WB, Direct ELISA in Human,Mouse,Rat.|
|Cross-Reactivity (Details)||No cross reactivity with other proteins.|
Rabbit IgG polyclonal antibody for NFAT2 detection. Tested with WB, Direct ELISA in Human,Mouse,Rat.
Gene Name: nuclear factor of activated T-cells 1
Protein Name: Nuclear factor of activated T-cells, cytoplasmic 1
|Purification||Immunogen affinity purified.|
|Immunogen||E. coli-derived huamn NFAT2 recombinant protein (Position: Q589-K652).|
Target Details NFATC1Product Details anti-NFATC1 Antibody Application Details Handling Images back to top
|Alternative Name||NFATC1 (NFATC1 Antibody Abstract)|
NFATC1(Nuclear factor of activated T-cells, cytoplasmic 1), also known as NFATC or NFAT2, is a protein that in humans is encoded by the NFATC1 gene. And it is also a component of the nuclear factor of activated T cells DNA-binding transcription complex. The NFATC1 gene is mapped on 18q23. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. NFATC1 was not detected in brain, liver, or kidney. NFATC1 is an inducible nuclear component which functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. The solution structure of the binary complex formed between the core DNA-binding domain of human NFATC1 and the 12-bp oligonucleotide duplex containing the ARRE2 DNA site from the IL2 promoter. Nfatc1 was expressed exclusively in mouse hair follicle stem cells, and using gain- and loss-of-function approaches, and Nfatc1 inhibited stem cell activation.
Synonyms: Nuclear factor of activated T-cells, cytoplasmic 1, NF-ATc1, NFATc1, NFAT transcription complex cytosolic component, NF-ATc, NFATc, NFATC1, NFAT2, NFATC
|Pathways||RTK Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway|
Application DetailsProduct Details anti-NFATC1 Antibody Target Details NFATC1 Handling Images back to top
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.
|Restrictions||For Research Use only|
HandlingProduct Details anti-NFATC1 Antibody Target Details NFATC1 Application Details Images back to top
|Reconstitution||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|Buffer||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C,-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.