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|Antigen||Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3) Antibodies|
|Epitope||Extracellular Domain Alternatives|
|Reactivity||Rat (Rattus), Mouse (Murine), Human Alternatives|
|Conjugate||This NTRK3 antibody is un-conjugated Alternatives|
|8 references available|
|Supplier||Log in to see|
Product Details anti-NTRK3 AntibodyTarget Details NTRK3 Application Details Handling References for anti-NTRK3 antibody (ABIN351086) Images
|Specificity||Specific for TrkC.|
|Immunogen||A synthetic peptide from the extracellular domain of rat TrkC conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse and human.|
Target Details NTRK3Product Details anti-NTRK3 Antibody Application Details Handling References for anti-NTRK3 antibody (ABIN351086) Images back to top
|Alternative Name||TrkC (NTRK3 Antibody Abstract)|
Function: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS.
Subcellular location: Membrane, Single-pass type I membrane protein.
Tissue specificity: Widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. Also known as: Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, GP145-TrkC, Trk-C, NT-3 growth factor receptor, NTRK3.
|Pathways||RTK Signaling, Neurotrophin Signaling Pathway, Regulation of Cell Size|
Application DetailsProduct Details anti-NTRK3 Antibody Target Details NTRK3 Handling References for anti-NTRK3 antibody (ABIN351086) Images back to top
A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
|Restrictions||For Research Use only|
HandlingProduct Details anti-NTRK3 Antibody Target Details NTRK3 Application Details References for anti-NTRK3 antibody (ABIN351086) Images back to top
|Reconstitution||Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.|
|Handling Advice||Avoid freeze and thaw cycles.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Expiry Date||12 months|
References for anti-NTRK3 antibody (ABIN351086)Product Details anti-NTRK3 Antibody Target Details NTRK3 Application Details Handling Images back to top
Ballif, Carey, Sunyaev, Gygi: "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." in: Journal of proteome research, Vol. 7, Issue 1, pp. 311-8, 2008
Qian, Riccio, Zhang, Ginty: "Identification and characterization of novel substrates of Trk receptors in developing neurons." in: Neuron, Vol. 21, Issue 5, pp. 1017-29, 1999
Ultsch, Wiesmann, Simmons, Henrich, Yang, Reilly, Bass, de Vos: "Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC." in: Journal of molecular biology, Vol. 290, Issue 1, pp. 149-59, 1999
McGregor, Baylin, Griffin, Hawkins, Nelkin: "Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant." in: Genomics, Vol. 22, Issue 2, pp. 267-72, 1995
Shelton, Sutherland, Gripp, Camerato, Armanini, Phillips, Carroll, Spencer, Levinson: "Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 15, Issue 1 Pt 2, pp. 477-91, 1995
Merlio, Ernfors, Jaber, Persson: "Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system." in: Neuroscience, Vol. 51, Issue 3, pp. 513-32, 1993
Tsoulfas, Soppet, Escandon, Tessarollo, Mendoza-Ramirez, Rosenthal, Nikolics, Parada: "The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells." in: Neuron, Vol. 10, Issue 5, pp. 975-90, 1993
Valenzuela, Maisonpierre, Glass, Rojas, Nuunez, Kong, Gies, Stitt, Ip, Yancopoulos: "Alternative forms of rat TrkC with different functional capabilities." in: Neuron, Vol. 10, Issue 5, pp. 963-74, 1993
ImagesProduct Details anti-NTRK3 Antibody Target Details NTRK3 Application Details Handling References for anti-NTRK3 antibody (ABIN351086) back to top