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|Antigen||Platelet Derived Growth Factor BB (PDGFBB) Antibodies|
|Conjugate||This PDGFBB antibody is un-conjugated Alternatives|
Functional Studies (Func), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
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Product Details anti-PDGFBB AntibodyTarget Details PDGFBB Application Details Handling Images
|Specificity||Human PDGF-BB (Platelet derived growth factor B chain), a disulphide-linked beta-chain homodimer and member of the PDGF family, released from platelet alpha-granules following trauma/platelet activation. Naturally occurring active forms of PDGF exist as dimers of two alpha chains (AA), two beta chains (BB), or a combination of both chains (AB), all of which signal through the high-affinity PDGF-Ralpha receptor, and the latter two of which can also signal through the PDGF-Rbeta receptor. PDGFs are potent mitogens for a variety of cells including those of the connective tissue, bone and cartilage, blood and smooth muscle cells, and are involved in several biological processes including chemotaxis, hyperplasia and embryonic neurogenesis. The expression of PDGF-BB is associated with autocrine growth stimulation and the formation of various tumor types, with several studies focusing on dermatofibrosarcoma protuberans (DP), an infiltrating skin tumor arising from a translocation occurring between chromosome 22 (the location of the PDGFB gene) and chromosome 17 (the location of the COL1A1 gene), which results in the generation of the COL1A1-PDGFB chimeric protein.|
Recombinant human PDGF BB.
Type of Immunogen: Recombinant protein
Target Details PDGFBBProduct Details anti-PDGFBB Antibody Application Details Handling Images back to top
|Alternative Name||PDGF-BB (PDGFBB Antibody Abstract)|
Name/Gene ID: PDGFB
Synonyms: PDGFB, Becaplermin, PDGF-BB, PDGF-b, SSV, PDGF subunit B, PDGF-2, PDGF2, Proto-oncogene c-Sis, SIS, C-sis, PDGF, B chain
|Pathways||RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling|
Application DetailsProduct Details anti-PDGFBB Antibody Target Details PDGFBB Handling Images back to top
Approved: ELISA (1:2000 - 1:8000), Func, IHC-P, WB
Usage: This product requires protein digestion pre-treatment of paraffin sections e.g. trypsin or proteinase K.
|Restrictions||For Research Use only|
HandlingProduct Details anti-PDGFBB Antibody Target Details PDGFBB Application Details Images back to top
|Buffer||PBS, pH 7.4, 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
ImagesProduct Details anti-PDGFBB Antibody Target Details PDGFBB Application Details Handling back to top