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|Antigen||Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) Antibodies|
|Conjugate||This PDGFRA antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
|5 references available|
|Supplier||Log in to see|
Product Details anti-PDGFRA AntibodyTarget Details PDGFRA Application Details Handling References for anti-PDGFRA antibody (ABIN359906) Images
|Specificity||This antibody reacts to PDGFRA.|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PDGFRA.|
Target Details PDGFRAProduct Details anti-PDGFRA Antibody Application Details Handling References for anti-PDGFRA antibody (ABIN359906) Images back to top
|Alternative Name||CD140a / PDGFRA (PDGFRA Antibody Abstract)|
|Background||PDGFRA is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.Synonyms: Alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, PDGF Receptor alpha, PDGF-R-alpha|
|Gene ID||5156, 9606|
|Pathways||RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Platelet-derived growth Factor Receptor Signaling|
Application DetailsProduct Details anti-PDGFRA Antibody Target Details PDGFRA Handling References for anti-PDGFRA antibody (ABIN359906) Images back to top
ELISA: 1/1,000. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-PDGFRA Antibody Target Details PDGFRA Application Details References for anti-PDGFRA antibody (ABIN359906) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-PDGFRA antibody (ABIN359906)Product Details anti-PDGFRA Antibody Target Details PDGFRA Application Details Handling Images back to top
Cools, DeAngelo, Gotlib, Stover, Legare, Cortes, Kutok, Clark, Galinsky, Griffin, Cross, Tefferi, Malone, Alam, Schrier, Schmid, Rose, Vandenberghe, Verhoef, Boogaerts, Wlodarska, Kantarjian, Marynen et al.: "A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. ..." in: The New England journal of medicine, Vol. 348, Issue 13, pp. 1201-14, 2003
Heinrich, Corless, Duensing, McGreevey, Chen, Joseph, Singer, Griffith, Haley, Town, Demetri, Fletcher, Fletcher: "PDGFRA activating mutations in gastrointestinal stromal tumors." in: Science (New York, N.Y.), Vol. 299, Issue 5607, pp. 708-10, 2003
Ribom, Andrae, Frielingsdorf, Hartman, Nistér, Smits: "Prognostic value of platelet derived growth factor alpha receptor expression in grade 2 astrocytomas and oligoastrocytomas." in: Journal of neurology, neurosurgery, and psychiatry, Vol. 72, Issue 6, pp. 782-7, 2002
Andrae, Molander, Smits, Funa, Nistér: "Platelet-derived growth factor-B and -C and active alpha-receptors in medulloblastoma cells." in: Biochemical and biophysical research communications, Vol. 296, Issue 3, pp. 604-11, 2002
Kawagishi, Kumabe, Yoshimoto, Yamamoto: "Structure, organization, and transcription units of the human alpha-platelet-derived growth factor receptor gene, PDGFRA." in: Genomics, Vol. 30, Issue 2, pp. 224-32, 1996
ImagesProduct Details anti-PDGFRA Antibody Target Details PDGFRA Application Details Handling References for anti-PDGFRA antibody (ABIN359906) back to top