anti-Human PDGFRA antibody for Enzyme Immunoassay

Recommended PDGFRA Antibody (supplied by: Log in to see )

Antigen
Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) Antibodies
  • AI115593
  • CD140a
  • Pdgfr-2
  • APDGFR
  • PDGFACE
  • CD140A
  • PDGFR-2
  • PDGFR2
  • RHEPDGFRA
  • PDGFR
  • PDGFR-A
  • platelet derived growth factor receptor alpha
  • platelet derived growth factor receptor, alpha polypeptide
  • platelet-derived growth factor receptor, alpha polypeptide L homeolog
  • platelet-derived growth factor receptor, alpha polypeptide
  • PDGFRA
  • Pdgfra
  • pdgfra.L
Epitope
C-Term
48
27
20
17
15
15
15
15
15
14
12
11
11
11
11
10
10
10
9
8
7
7
6
6
6
5
5
5
5
5
5
4
4
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
479
255
158
7
6
6
6
6
4
3
3
3
2
2
1
1
1
1
1
Host
Rabbit
353
151
49
3
1
Clonality
Polyclonal
Conjugate
This PDGFRA antibody is un-conjugated
36
31
31
26
22
14
13
12
7
7
7
7
6
5
5
5
5
5
5
5
5
5
5
5
3
3
3
2
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
334
202
198
136
108
67
50
45
15
14
11
9
8
4
3
3
1
1
1
1
1
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Catalog No. ABIN359906
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN359912 EIA IHC (p) WB Rabbit Ig Fraction Tyr768 Log in to see Polyclonal 5
1 ABIN359914 EIA IF IHC (p) WB Rabbit Ig Fraction Tyr754 Log in to see Polyclonal 5
1 ABIN359910 EIA IHC (p) WB Rabbit Ig Fraction Tyr762 Log in to see Polyclonal 2
1 ABIN359908 EIA IHC (p) WB Rabbit Ig Fraction Tyr720 Log in to see Polyclonal 2
1 ABIN5611421 EIA IHC (p) Rabbit IgG C-Term Log in to see Polyclonal 0
1 ABIN372897 EIA IHC (p) WB Rabbit IgG C-Term Log in to see Polyclonal 0
1 ABIN303439 EIA IHC (p) Rabbit AA 1063-1077 Log in to see Polyclonal 0
1 ABIN110689 EIA IHC (p) WB Mouse IgG1 Extracellular Domain Log in to see 57-20 (35248) 0

General

Antigen Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) Antibodies
Epitope C-Term
(48), (27), (20), (17), (15), (15), (15), (15), (15), (14), (12), (11), (11), (11), (11), (10), (10), (10), (9), (8), (7), (7), (6), (6), (6), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(479), (255), (158), (7), (6), (6), (6), (6), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1)
Host Rabbit
(353), (151), (49), (3), (1)
Clonality
Polyclonal
Conjugate This PDGFRA antibody is un-conjugated
(36), (31), (31), (26), (22), (14), (13), (12), (7), (7), (7), (7), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (3), (3), (3), (2), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(334), (202), (198), (136), (108), (67), (50), (45), (15), (14), (11), (9), (8), (4), (3), (3), (1), (1), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-PDGFRA Antibody

Target Details PDGFRA Application Details Handling References for anti-PDGFRA antibody (ABIN359906) Images
Specificity This antibody reacts to PDGFRA.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PDGFRA.
Isotype Ig Fraction

Target Details PDGFRA

Product Details anti-PDGFRA Antibody Application Details Handling References for anti-PDGFRA antibody (ABIN359906) Images back to top
Antigen
Alternative Name CD140a / PDGFRA (PDGFRA Antibody Abstract)
Background PDGFRA is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.Synonyms: Alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, PDGF Receptor alpha, PDGF-R-alpha
Gene ID 5156, 9606
UniProt P16234
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Platelet-derived growth Factor Receptor Signaling

Application Details

Product Details anti-PDGFRA Antibody Target Details PDGFRA Handling References for anti-PDGFRA antibody (ABIN359906) Images back to top
Application Notes ELISA: 1/1,000. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-PDGFRA Antibody Target Details PDGFRA Application Details References for anti-PDGFRA antibody (ABIN359906) Images back to top
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

References for anti-PDGFRA antibody (ABIN359906)

Product Details anti-PDGFRA Antibody Target Details PDGFRA Application Details Handling Images back to top
Background publications

Cools, DeAngelo, Gotlib, Stover, Legare, Cortes, Kutok, Clark, Galinsky, Griffin, Cross, Tefferi, Malone, Alam, Schrier, Schmid, Rose, Vandenberghe, Verhoef, Boogaerts, Wlodarska, Kantarjian, Marynen et al.: "A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. ..." in: The New England journal of medicine, Vol. 348, Issue 13, pp. 1201-14, 2003

Heinrich, Corless, Duensing, McGreevey, Chen, Joseph, Singer, Griffith, Haley, Town, Demetri, Fletcher, Fletcher: "PDGFRA activating mutations in gastrointestinal stromal tumors." in: Science (New York, N.Y.), Vol. 299, Issue 5607, pp. 708-10, 2003

Ribom, Andrae, Frielingsdorf, Hartman, Nistér, Smits: "Prognostic value of platelet derived growth factor alpha receptor expression in grade 2 astrocytomas and oligoastrocytomas." in: Journal of neurology, neurosurgery, and psychiatry, Vol. 72, Issue 6, pp. 782-7, 2002

Andrae, Molander, Smits, Funa, Nistér: "Platelet-derived growth factor-B and -C and active alpha-receptors in medulloblastoma cells." in: Biochemical and biophysical research communications, Vol. 296, Issue 3, pp. 604-11, 2002

Kawagishi, Kumabe, Yoshimoto, Yamamoto: "Structure, organization, and transcription units of the human alpha-platelet-derived growth factor receptor gene, PDGFRA." in: Genomics, Vol. 30, Issue 2, pp. 224-32, 1996

Images

Product Details anti-PDGFRA Antibody Target Details PDGFRA Application Details Handling References for anti-PDGFRA antibody (ABIN359906) back to top
Supplier Images
 image for anti-Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) (C-Term) antibody (ABIN359906) anti-Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) (C-Term) antibody