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anti-Mouse (Murine) PPP3CB Antibodies:
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Human Polyclonal PPP3CB Primary Antibody for IHC (p), ELISA - ABIN543122
Bennasser, Badou, Tkaczuk, Bahraoui: Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha. in Virology 2002
Show all 3 Pubmed References
Transient high ductal pressure produces pancreatic inflammation and loss of tight junction integrity via calcineurin signaling.
NFAT is activated through calcineurin and interacts with NFsmall ka, CyrillicB after P. aeruginosa lung infection, and contributes to the host inflammatory response.
CnAbeta1 is mainly localized at the Golgi apparatus through its C-terminal domain. CnAbeta1 is needed for mTORC2 localization and activation at the cellular membranes. CnAbeta1 regulates differentiation of mouse embryonic stem cells to mesoderm.
Data indicate that calcineurin (CnAalpha-/- or CnAbeta-/-) is required for pathological but not compensatory renal hypertrophy.
CaM plays an active role in shaping both the spatial and temporal aspects of calcineurin-mediated calcium signaling.
CnAbeta/NFAT pathway modulates Nox.
Calcineurin regulates degradation of phosphodiesterase 3B, in addition to phosphodiesterase 4D.
loss of beta isoform of calcineurin is sufficient to reproduce aspects of cyclosporine on diabetic renal hypertrophy but not matrix expansion; calcineurin beta appears to be a central mechanism involved in organ hypertrophy
Results indicate that myospryn functions as a novel inhibitor of the calcineurin signaling pathway in skeletal muscle.
Calcineurin Abeta1 shows a unique mode of action that improves cardiac function after myocardial infarction, activating different cardioprotective pathways without inducing maladaptive hypertrophy
A novel-splicing variant of calcineurin Ass CnAss-FK, which is encoded by an intron-retaining mRNA and is deficient in the autoinhibitory domain, is predominantly expressed in mature follicular keratinocytes.
Calcineurin Abeta is important for the production and maintenance of Treg cells and to ensure mature T-cell quiescence.
Results identify a novel signaling process governing G-protein-coupled cAMP signal transduction-opposing actions of the phosphatase calcineurin and the CK1/GSK3beta protein kinases on the phosphodegron-dependent degradation of PDE4D.
calcineurin activation in skeletal muscle increases mitochondrial oxidative function and energy substrate storage, which contributes to enhanced endurance exercise performance
Plasma renin concentrations were not different in wild-type, calcineurin A-alpha, or A-beta knockout mice.
Total peripheral T cell numbers were significantly reduced in CnA beta(-/-) mice and were defective in proliferative capacity and IL-2 production in response to PMA/ionomycin and T cell receptor cross-linking.
Calcineurin Abeta knockout mice predisposes the myocardium to acute mycardial reperfusion injury.
calcineurin expression is important during myogenesis and fiber-type switching, but not for muscle growth in response to hypertrophic stimuli
absence of CnA-alpha but not CnA-beta leads to a defect in normal maturation of the NZ and glomeruli, alterations in the cell cycle, and impaired kidney function
CnAbeta is also required for the homeostatic survival of naive T cells.
The mRNA expressions of PPP3CB and MEF2C were significantly up-regulated, and CAMK1 and PPP3R1 were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB, MEF2C and PLCE1 compared to aortic valve disease patients
These findings therefore provide initial support for the novel mechanistic hypothesis that oxidation-induced global and/or local conformational changes within calcineurin
lower expression of PPP3CA and PPP3CB genes in atrium myocardium can be related to expressed postinfarction LV remodeling.
Present findings indicate that downregulation of hemoxygenase-1 expression in neutrophils from hypertensive subjects is likely mediated by CN, which acts by hindering translocation to the nucleus of the transcription factor NRF2.
The C allele of protein phosphatase 3 subunit alpha rs3804358 polymorphism was overrepresented in athletes compared with controls, whereas the T allele of protein phosphatase 3 subunit beta rs3763679 polymorphism was underrepresented in athletes.
ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes are potential candidate genes for schizophrenia, especially in patients with deficits in sustained attention and executive function.
The expression of a constitutively active Calcineurin stimulates myoblast differentiation, whereas a Calcineurin antisense has the opposite effect.
two new complementary roles for calcineurin in the regulation of the early UPR (Unfolded Protein Responses)
[review] The nuclear localization sequence, a region spanning amino acids 172-183 of calcineurin A beta, is essential for recognition and shuttling of calcineurin into the nucleus by importin beta.
calcineurin regulates AUF1 posttranslationally in vitro and PTH gene expression in vivo but still allows its physiological regulation by calcium and phosphate
depressed NCX activity might contribute to the etiology of in vivo cardiac hypertrophy and dysfunction occurring under conditions in which both calcineurin and protein kinase C are chronically activated
Calcineurin A beta expression is an additional means of regulating calcineurin activity in the heart.
Data show that the calcineurin pathway is activated in hypertrophic myocardium as demonstrated by increased calcineurin activity and expression of calcineurin A-beta and B, and GATA-4, and a shift of cytoplasmic NFAT-3 into the nucleus.
We describe a case of Calcineurin inhibitor-mediated bilateral hippocampal injury after bone marrow transplantation.
TAK1-TAB1-TAB2 selectively induces calcineurin-NFAT signalling through direct phosphorylation of RCAN1, while calcineurin activation diminishes TAK1 signalling by dephosphorylation of TAK1 and TAB1.
Study demonstrates that all CaN isoforms display the same cytoplasmic subcellular distribution and are expressed in each tested cell line, differences in substrate specificities may determine specific physiological functions of the distinct isoforms.
calcineurin is inhibited by cyclosporine A, which then exerts multiple effects on human melanoma cell lines HT168 and WM35
calcineurin can dephosphorylate GSK-3beta at Ser-9 and form a stable complex with GSK-3beta, suggesting the possibility that calcineurin regulates the dephosphorylation and activation of GSK-3betain vivo
Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
calcineurin A beta
, protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform
, serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
, CAM-PRP catalytic subunit
, PP2BA beta
, calmodulin-dependent calcineurin A subunit beta isoform
, calcineurin A2
, protein phosphatase 2B, catalytic subunit, beta isoform
, protein phosphatase from PCR fragment H32
, CaN Abeta
, Calcineurin subunit A beta
, protein phosphatase 3, catalytic subunit, beta isoform
, protein phosphatase-2Bb