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General |
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Antigen | PTK7 Protein tyrosine Kinase 7 (PTK7) Antibodies |
Epitope | N-Term Alternatives |
Reactivity | Chicken, Human, Mouse (Murine) Alternatives |
Host | Rabbit Alternatives |
Clonality | |
Conjugate | This PTK7 antibody is un-conjugated Alternatives |
Application |
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
Alternatives
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Supplier | Log in to see |
Product Details anti-PTK7 AntibodyTarget Details PTK7 Application Details Handling Images |
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Specificity | This antibody reacts specifically with Human 112 kDa CCK-4. |
Cross-Reactivity (Details) |
Species reactivity (expected):Mouse and Chicken. Species reactivity (tested):Human. |
Purification | Affinity Chromatography on Protein A |
Immunogen | Synthetic peptide derived from Human N-terminal region of CCK-4 |
Target Details PTK7Product Details anti-PTK7 Antibody Application Details Handling Images back to top |
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Antigen | |
Alternative Name | PTK7 / CCK4 (PTK7 Antibody Abstract) |
Background | PTK7 is a member of the receptor tyrosine kinase family otherwise known as Colon Carcinoma Kinase 4 (CCK4). PTK7 is highly expressed in the kidney, liver, lung, pancreas and melanocytes with weaker expression being detected in the thyroid gland, ovaries, brain, heart and skeletal muscle. PTK7 may play a role in embryonic development. It is thought to function as a cell adhesion molecule and as a novel regulator of the planar cell polarity (PCP) pathway in vertebrates. Studies also suggest that PTK7 may be involved in the tumour progression. A loss of PTK7 expression has been observed in melanoma cell lines, whereas increased levels of PTK7 have been detected in high-throughput acute myeloid leukaemia samples. In addition, PTK7 is not expressed in normal colon but has been detected in colon carcinomas and as such is a potential marker for tumour progression.Synonyms: CCK-4, Colon carcinoma kinase 4, Tyrosine-protein kinase-like 7 |
Gene ID | 5754 |
NCBI Accession | NP_002812 |
Pathways | RTK Signaling, Tube Formation |
Application DetailsProduct Details anti-PTK7 Antibody Target Details PTK7 Handling Images back to top |
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Application Notes | Optimal working dilution should be determined by the investigator. |
Restrictions | For Research Use only |
HandlingProduct Details anti-PTK7 Antibody Target Details PTK7 Application Details Images back to top |
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Reconstitution | Restore in distilled water. |
Handling Advice | Avoid repeated freezing and thawing. |
Storage | 4 °C/-20 °C |
Storage Comment | Prior to reconstitution store the antibody at -20 °C. Store reconstituted antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer |