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|Antigen||PTK7 Protein tyrosine Kinase 7 (PTK7) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This PTK7 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-PTK7 AntibodyTarget Details PTK7 Application Details Handling Images
|Specificity||This antibody detects PTK7 at C-term.|
|Cross-Reactivity (Details)||Species reactivity (tested):Human, mouse, rat|
|Purification||Peptide affinity chromatography|
|Immunogen||PTK7 antibody was raised against a 18 amino acid peptide from near the carboxy terminus of human PTK7.|
Target Details PTK7Product Details anti-PTK7 Antibody Application Details Handling Images back to top
|Alternative Name||PTK7 / CCK4 (PTK7 Antibody Abstract)|
|Background||Protein-tyrosine kinases (PTKs) play important roles in regulating cell proliferation and differentiation during development. One member of the PTK family, PTK7, has been suggested to regulate the planar cell polarity (PCP) pathway in vertebrates and may play a role in neural convergent extension and neural tube closure. PTK7 has also been implicated in the development of cancer. Loss of PTK7 expression was seen in several melanoma cell lines and biopsies. Conversely, high-throughput analysis of acute myeloid leukemia samples showed an increased level of PTK7 expression compared to normal bone marrow and purified CD34+ cells. Multiple isoforms of PTK7 are known to exist.Synonyms: CCK-4, Colon carcinoma kinase 4, Tyrosine-protein kinase-like 7|
|Pathways||RTK Signaling, Tube Formation|
Application DetailsProduct Details anti-PTK7 Antibody Target Details PTK7 Handling Images back to top
ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-PTK7 Antibody Target Details PTK7 Application Details Images back to top
|Buffer||PBS containing 0.02 % sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.|