anti-Mouse (Murine) Ret Proto-Oncogene antibody for Immunohistochemistry (Frozen Sections)

Recommended Ret Proto-Oncogene Antibody (supplied by: Log in to see )

Antigen
Ret Proto-Oncogene (RET) Antibodies
  • c-ret
  • cret
  • etID315074.13
  • ret1
  • wu:fd13h01
  • X-ret
  • ret-A
  • xret
  • RET
  • MTC1
  • CDHF12
  • CDHR16
  • HSCR1
  • MEN2A
  • MEN2B
  • PTC
  • RET-ELE1
  • RET51
  • RET9
  • c-Ret
  • ret proto-oncogene receptor tyrosine kinase
  • ret proto-oncogene
  • ret
  • RET
  • Ret
Epitope
Extracellular Domain
53
41
30
28
25
22
22
15
14
14
12
11
8
8
8
8
8
8
6
5
4
4
4
4
3
3
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine)
396
117
106
9
3
2
2
2
2
1
1
1
1
1
1
1
Host
Goat
246
148
4
2
1
1
Clonality
Polyclonal
Conjugate
This Ret Proto-Oncogene antibody is un-conjugated
17
15
15
12
12
9
9
9
8
8
8
5
5
5
5
5
5
4
4
2
2
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
273
143
93
82
65
61
27
8
6
5
4
4
3
3
1
Options
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Catalog No. ABIN289533
$ 1,011.26
Plus shipping costs $45.00

General

Antigen Ret Proto-Oncogene (RET) Antibodies
Epitope Extracellular Domain
(53), (41), (30), (28), (25), (22), (22), (15), (14), (14), (12), (11), (8), (8), (8), (8), (8), (8), (6), (5), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Mouse (Murine)
(396), (117), (106), (9), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Host Goat
(246), (148), (4), (2), (1), (1)
Clonality
Polyclonal
Conjugate This Ret Proto-Oncogene antibody is un-conjugated
(17), (15), (15), (12), (12), (9), (9), (9), (8), (8), (8), (5), (5), (5), (5), (5), (5), (4), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
(273), (143), (93), (82), (65), (61), (27), (8), (6), (5), (4), (4), (3), (3), (1)
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Product Details anti-Ret Proto-Oncogene Antibody

Target Details Ret Proto-Oncogene Application Details Handling Images
Purification Purified
Immunogen Ret antibody was raised in goat using NSO derived murine ret extracellular domain as the immunogen.

Target Details Ret Proto-Oncogene

Product Details anti-Ret Proto-Oncogene Antibody Application Details Handling Images back to top
Antigen
Alternative Name Ret (RET Antibody Abstract)
Background The Ret proto-oncogene (c-Ret) is a receptor tyrosine kinase that functions as a multicompetent receptor complex in conjunction with other membrane-bound ligand-binding GDNF family receptors. Ligands that bind the Ret receptor include the glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Alterations in the corresponding Ret gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma and a congenital developmental disorder known as Hirschsprung’s disease. The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr905 dramatically inhibits Ret autophosphorylation activity.
Research Area Cancer, Tyrosine Kinases, Signaling, Kinases/Phosphatases
Pathways RTK Signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation

Application Details

Product Details anti-Ret Proto-Oncogene Antibody Target Details Ret Proto-Oncogene Handling Images back to top
Application Notes ELISA: 0.5-1 μg/mL, IHC-F: 5 μg/mL, IHC-P: 10-15 μg/mL, WB: 0.1-0.2 μg/mL
Optimal conditions should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-Ret Proto-Oncogene Antibody Target Details Ret Proto-Oncogene Application Details Images back to top
Format Lyophilized
Reconstitution Reconstitute with PBS.
Concentration Lot specific
Buffer Lyophilized from PBS, pH 7.2 containing 5 % trehalose.
Handling Advice Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.
Storage -80 °C
Storage Comment Aliquot and store at -70 °C or lower.