|Antigen||Ret Proto-Oncogene (RET) Antibodies|
|Epitope||Extracellular Domain Alternatives|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This Ret Proto-Oncogene antibody is un-conjugated Alternatives|
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
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Product Details anti-Ret Proto-Oncogene AntibodyTarget Details Ret Proto-Oncogene Application Details Handling Images
|Immunogen||Ret antibody was raised in goat using NSO derived murine ret extracellular domain as the immunogen.|
Target Details Ret Proto-OncogeneProduct Details anti-Ret Proto-Oncogene Antibody Application Details Handling Images back to top
|Alternative Name||Ret (RET Antibody Abstract)|
|Background||The Ret proto-oncogene (c-Ret) is a receptor tyrosine kinase that functions as a multicompetent receptor complex in conjunction with other membrane-bound ligand-binding GDNF family receptors. Ligands that bind the Ret receptor include the glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Alterations in the corresponding Ret gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma and a congenital developmental disorder known as Hirschsprung’s disease. The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr905 dramatically inhibits Ret autophosphorylation activity.|
|Research Area||Cancer, Tyrosine Kinases, Signaling, Kinases/Phosphatases|
|Pathways||RTK Signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation|
Application DetailsProduct Details anti-Ret Proto-Oncogene Antibody Target Details Ret Proto-Oncogene Handling Images back to top
ELISA: 0.5-1 μg/mL, IHC-F: 5 μg/mL, IHC-P: 10-15 μg/mL, WB: 0.1-0.2 μg/mL
Optimal conditions should be determined by the investigator.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Ret Proto-Oncogene Antibody Target Details Ret Proto-Oncogene Application Details Images back to top
|Reconstitution||Reconstitute with PBS.|
|Buffer||Lyophilized from PBS, pH 7.2 containing 5 % trehalose.|
Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.
|Storage Comment||Aliquot and store at -70 °C or lower.|