anti-Rat (Rattus) Ret Proto-Oncogene antibody for Immunocytochemistry

Recommended Ret Proto-Oncogene Antibody (supplied by: Log in to see )

Antigen
Ret Proto-Oncogene (RET) Antibodies
  • c-ret
  • cret
  • etID315074.13
  • ret1
  • wu:fd13h01
  • X-ret
  • ret-A
  • xret
  • RET
  • MTC1
  • CDHF12
  • CDHR16
  • HSCR1
  • MEN2A
  • MEN2B
  • PTC
  • RET-ELE1
  • RET51
  • RET9
  • c-Ret
  • ret proto-oncogene receptor tyrosine kinase
  • ret proto-oncogene S homeolog
  • ret proto-oncogene
  • ret
  • ret.S
  • RET
  • Ret
Epitope
pTyr1096
49
42
26
26
26
22
18
15
14
11
11
8
7
7
7
7
7
7
7
6
5
5
4
4
3
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
362
128
118
9
3
2
2
2
2
1
1
1
1
1
1
1
Host
Rabbit
256
104
5
2
1
1
Clonality
Polyclonal
Conjugate
This Ret Proto-Oncogene antibody is un-conjugated
16
14
14
12
9
9
6
6
6
6
6
5
5
5
5
5
5
1
1
1
1
1
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
270
155
122
67
65
39
34
12
7
6
6
3
3
1
1
Supplier
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Catalog No. ABIN6271278
$ 450.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
16 ABIN6271568 ELISA ICC IF IHC WB Rabbit IgG pTyr1015 Log in to see Polyclonal 0
10 ABIN6256615 ELISA ICC IF WB Rabbit IgG pTyr1062 Log in to see Polyclonal 0
10 ABIN6264702 ELISA ICC IF WB Rabbit IgG Log in to see Polyclonal 0
7 ABIN6271276 ELISA ICC IF WB Rabbit IgG pTyr905 Log in to see Polyclonal 0
1 ABIN2744032 ICC IF IHC IHC (p) WB Rabbit C-Term Log in to see Polyclonal 0
1 ABIN2744030 ICC IF IHC IHC (p) WB Rabbit C-Term Log in to see Polyclonal 0

General

Antigen Ret Proto-Oncogene (RET) Antibodies
Epitope pTyr1096
(49), (42), (26), (26), (26), (22), (18), (15), (14), (11), (11), (8), (7), (7), (7), (7), (7), (7), (7), (6), (5), (5), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(362), (128), (118), (9), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Host Rabbit
(256), (104), (5), (2), (1), (1)
Clonality
Polyclonal
Conjugate This Ret Proto-Oncogene antibody is un-conjugated
(16), (14), (14), (12), (9), (9), (6), (6), (6), (6), (6), (5), (5), (5), (5), (5), (5), (1), (1), (1), (1), (1)
Application ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
(270), (155), (122), (67), (65), (39), (34), (12), (7), (6), (6), (3), (3), (1), (1)
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Product Details anti-Ret Proto-Oncogene Antibody

Target Details Ret Proto-Oncogene Application Details Handling Images
Specificity Ret (Phospho-Tyr1096) Antibody detects endogenous levels of Ret only when phosphorylated at Tyr1096
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Purification The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Immunogen A synthesized peptide derived from human Ret (Phospho-Tyr1096)
Isotype IgG
Plasmids, Primers & others

Target Details Ret Proto-Oncogene

Product Details anti-Ret Proto-Oncogene Antibody Application Details Handling Images back to top
Antigen
Alternative Name Ret (RET Antibody Abstract)
Background

Description: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis, involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor, in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers, these diseases are characterized by aberrant integrins-regulated cell migration. Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which induces inhibition of food-intake. Activates MAPK- and AKT-signaling pathways (PubMed:28846097, PubMed:28953886, PubMed:28846099). Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL (PubMed:28846099).

Gene: RET

Molecular Weight 175kDa
Gene ID 5979
UniProt P07949
Pathways RTK Signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation

Application Details

Product Details anti-Ret Proto-Oncogene Antibody Target Details Ret Proto-Oncogene Handling Images back to top
Application Notes WB 1:1000-3000, IHC 1:50-1:200, IF/ICC 1:100-1:500
Restrictions For Research Use only

Handling

Product Details anti-Ret Proto-Oncogene Antibody Target Details Ret Proto-Oncogene Application Details Images back to top
Format Liquid
Concentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20 °C.Stable for 12 months from date of receipt
Expiry Date 12 months

Images

Product Details anti-Ret Proto-Oncogene Antibody Target Details Ret Proto-Oncogene Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Ret Proto-Oncogene (RET) (pTyr1096) antibody (ABIN6271278) ABIN6271279 at 1/200 staining Human kidney tissue sections by IHC-P. The tissue was f...
Immunohistochemistry (IHC) image for anti-Ret Proto-Oncogene (RET) (pTyr1096) antibody (ABIN6271278) ABIN6271279 at 1/200 staining Mouse kidney tissue sections by IHC-P. The tissue was f...
Immunohistochemistry (IHC) image for anti-Ret Proto-Oncogene (RET) (pTyr1096) antibody (ABIN6271278) ABIN6271279 at 1/200 staining Rat kidney tissue sections by IHC-P. The tissue was for...
Immunofluorescence (fixed cells) (IF/ICC) image for anti-Ret Proto-Oncogene (RET) (pTyr1096) antibody (ABIN6271278) ABIN6271279 staining Hela cells by IF/ICC. The sample were fixed with PFA and permeab...
Western Blotting (WB) image for anti-Ret Proto-Oncogene (RET) (pTyr1096) antibody (ABIN6271278) Western blot analysis of Ret (Phospho-Tyr1096) using EGF treated HepG2 whole cell lys...