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ELMO2 (show ELMO2 Proteins)-RhoG-ILK (show ILK Proteins) complex has a key role in integrin-independent stabilization of the microtubule network in differentiated keratinocytes.
RhoG is expressed and activated in platelets, plays an important role in GPVI (show GP6 Proteins)-Fc receptor gamma-chain (show FCER1G Proteins) complex-mediated platelet activation, and is critical for thrombus formation in vivo.
RhoG protein regulates platelet granule secretion and thrombus formation in mice.
Examined the role of RhoG in the invasive behavior of glioblastoma cells; found that depletion of RhoG strongly inhibits activation of the Rac1 GTPase by both HGF and EGF; also RhoG contributes to the formation of lamellipodia and invadopodia.
several Rho family small GTPases activate PI3K by an indirect cooperative positive feedback that required a combination of Rac (show AKT1 Proteins), CDC42 (show CDC42 Proteins), and RhoG small GTPase (show RACGAP1 Proteins) activities
Results indicate that RhoG promotes neural progenitor cell proliferation through PI3K in cortical development.
RhoG function is mediated by signals independent of Rac1 and Cdc42 (show CDC42 Proteins) activation and instead by direct utilization of a subset of common effectors
different biological properties of RhoG and Rac1 can be traced to specific amino acid variations in their switch I, beta2/beta3 hairpin, alpha5 helix, and C-terminal polybasic regions.
In RhoG deficient mice, the development of B and T lymphocytes was unaffected. However, there was an increase in the level of serum IgG1 and IgG2b as well as a mild increase of the humoral immune response to thymus-dependent antigens.
define RhoG as a critical component of G protein-coupled receptor (show GPR34 Proteins)-stimulated signaling cascades in murine neutrophils
RhoG and SGEF modulate the phosphorylation of paxillin (show PXN Proteins), which plays a key role during invadopodia disassembly.
yrosine phosphorylation of SGEF suppresses its interaction with RhoG, the elevation of RhoG activity, and SGEF-mediated promotion of cell migration. We identified tyrosine 530 (Y530), which is located within the Dbl homology domain, as a major phosphorylation site of SGEF by Src, and Y530F mutation blocked the inhibitory effect of Src on SGEF
These results suggest that the levels of RhoG and RhoB GTPases and their negative regulator RhoGDI3 might be linked to the aggressiveness of the pancreatic cancerous cell lines. It is possible that RhoGDI3 could induce the downregulation of RhoG and RhoB.
These data suggest a novel link between Tiam1 and RhoG/ILK /ELMO2 pathway as upstream effectors of the Rac1-mediated phagocytic process in trabecular meshwork cells.
This study describes the regulation of EMT (show ITK Proteins) in RPE (show RPE Proteins) cells by TGF-beta1 (show TGFB1 Proteins)/miR (show MLXIP Proteins)-124/RHOG signaling and suggests that the supplement of miR (show MLXIP Proteins)-124 exogenously would be a valuable therapeutic approach for the prevention or treatment of proliferative vitreoretinopathy.
several Rho family small GTPases activate PI3K (show PIK3CA Proteins) by an indirect cooperative positive feedback that required a combination of Rac (show AKT1 Proteins), CDC42 (show CDC42 Proteins), and RhoG small GTPase (show RACGAP1 Proteins) activities
The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity.
The activation of RhoG recruits its effector ELMO2 (show ELMO2 Proteins) and a Rac (show AKT1 Proteins) GEF (show SLC2A4RG Proteins) Dock4 to form a complex with EphA2 (show EPHA2 Proteins) at the tips of cortactin (show CTTN Proteins)-rich protrusions in migrating breast cancer cells.
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X.
aplysia ras-related homolog G (RhoG)
, ras homolog G (RhoG)
, rho-related GTP-binding protein RhoG
, sid 10750
, ras homolog gene family, member G (rho G)
, rho G