anti-Human ROR1 antibody for Intracellular Flow Cytometry

Recommended ROR1 Antibody (supplied by: Log in to see )

Antigen
Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) Antibodies
  • ROR1
  • 9530021D13Rik
  • Nr1f1
  • ROR2
  • ROR3
  • nmf267
  • sg
  • staggerer
  • tmgc26
  • NTRKR1
  • dJ537F10.1
  • 2810404D04Rik
  • Ntrkr1
  • mRor1
  • RGD1559469
  • receptor tyrosine kinase like orphan receptor 1
  • RAR-related orphan receptor alpha
  • receptor tyrosine kinase-like orphan receptor 1
  • ROR1
  • Rora
  • Ror1
Reactivity
Human
125
55
45
5
3
3
3
3
2
2
1
1
1
1
1
Host
Mouse
117
32
17
Clonality
Monoclonal
Conjugate
This ROR1 antibody is conjugated to APC
10
10
7
7
6
5
4
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Intracellular Flow Cytometry (ICFC)
128
67
41
22
16
11
6
6
4
3
3
1
1
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

Submit your validation data for this product and get a full refund. I want to validate this product

Learn more

Pubmed
7 references available

Available images

Flow Cytometry (FACS) image for anti-Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) antibody (APC) (ABIN2658385)
Catalog No. ABIN2658385
Contact our Customer Service for availability and price in your country.
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2658386 FACS IF ICFC APC Mouse IgG1 kappa Log in to see 2A2 7

General

Antigen Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) Antibodies
Reactivity Human
(125), (55), (45), (5), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1)
Host Mouse
(117), (32), (17)
Clonality (Clone)
Monoclonal   ( )
Conjugate This ROR1 antibody is conjugated to APC
(10), (10), (7), (7), (6), (5), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application Flow Cytometry (FACS), Immunofluorescence (IF), Intracellular Flow Cytometry (ICFC)
(128), (67), (41), (22), (16), (11), (6), (6), (4), (3), (3), (1), (1), (1), (1)
Pubmed 7 references available
Supplier Log in to see

Product Details anti-ROR1 Antibody

Target Details ROR1 Application Details Handling References for anti-ROR1 antibody (ABIN2658385) Images
Purification The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
Clone 2A2
Isotype IgG1 kappa

Target Details ROR1

Product Details anti-ROR1 Antibody Application Details Handling References for anti-ROR1 antibody (ABIN2658385) Images back to top
Antigen
Alternative Name ROR1 (ROR1 Antibody Abstract)
Background ROR1, also known as NTRKR1, is a type I transmembrane protein and member of the ROR subfamily of surface receptors. ROR1 consists of one frizzled domain, one Ig-like C2-type domain, one kringle domain, and one kinase domain with no catalytic activity. ROR1 is expressed on embryonic tissue, in the central nervous system and on some cancer cells, and is used as a marker for B-cell chronic lymphocytic leukemia. Wnt5a has been identified as a ligand for ROR1.
Pathways RTK Signaling, WNT Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha

Application Details

Product Details anti-ROR1 Antibody Target Details ROR1 Handling References for anti-ROR1 antibody (ABIN2658385) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-ROR1 Antibody Target Details ROR1 Application Details References for anti-ROR1 antibody (ABIN2658385) Images back to top
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-ROR1 antibody (ABIN2658385)

Product Details anti-ROR1 Antibody Target Details ROR1 Application Details Handling Images back to top
Background publications

Dave, Anver, Butcher, Brown, Khan, Wayne, Baskar, Rader: "Restricted cell surface expression of receptor tyrosine kinase ROR1 in pediatric B-lineage acute lymphoblastic leukemia suggests targetability with therapeutic monoclonal antibodies." in: PLoS ONE, Vol. 7, Issue 12, pp. e52655, 2013

Bicocca, Chang, Masouleh, Muschen, Loriaux, Druker, Tyner: "Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia." in: Cancer cell, Vol. 22, Issue 5, pp. 656-67, 2012

Zhang, Chen, Cui, Chuang, Yu, Wang-Rodriguez, Tang, Chen, Basak, Kipps: "ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth." in: PLoS ONE, Vol. 7, Issue 3, pp. e31127, 2012

Baskar, Wiestner, Wilson, Pastan, Rader: "Targeting malignant B cells with an immunotoxin against ROR1." in: mAbs, Vol. 4, Issue 3, pp. 349-61, 2012

Uhrmacher, Schmidt, Erdfelder, Poll-Wolbeck, Gehrke, Hallek, Kreuzer: "Use of the receptor tyrosine kinase-like orphan receptor 1 (ROR1) as a diagnostic tool in chronic lymphocytic leukemia (CLL)." in: Leukemia research, Vol. 35, Issue 10, pp. 1360-6, 2011

Yang, Baskar, Kwong, Kennedy, Wiestner, Rader: "Therapeutic potential and challenges of targeting receptor tyrosine kinase ROR1 with monoclonal antibodies in B-cell malignancies." in: PLoS ONE, Vol. 6, Issue 6, pp. e21018, 2011

Grumolato, Liu, Mong, Mudbhary, Biswas, Arroyave, Vijayakumar, Economides, Aaronson: "Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors." in: Genes & development, Vol. 24, Issue 22, pp. 2517-30, 2010

Images

Product Details anti-ROR1 Antibody Target Details ROR1 Application Details Handling References for anti-ROR1 antibody (ABIN2658385) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) antibody (APC) (ABIN2658385) anti-Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) antibody (APC)