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anti-Human ROR2 Antibodies:
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Human Polyclonal ROR2 Primary Antibody for FACS, IHC (p) - ABIN392044
Afzal, Rajab, Fenske, Oldridge, Elanko, Ternes-Pereira, Tüysüz, Murday, Patton, Wilkie, Jeffery: Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2. in Nature genetics 2000
Show all 7 Pubmed References
Human Polyclonal ROR2 Primary Antibody for IHC (p), WB - ABIN392046
Oldridge, Fortuna, Maringa, Propping, Mansour, Pollitt, DeChiara, Kimble, Valenzuela, Yancopoulos, Wilkie: Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B. in Nature genetics 2000
Show all 6 Pubmed References
Wnt5a (show WNT5A Antibodies) suppressed osteoblastic differentiation through Ror2/JNK (show MAPK8 Antibodies) signaling in periodontal ligament stem cell-like cells.
Data show that receptor tyrosine kinase-like orphan receptor 2 (ROR2) is epigenetically silenced by promoter hypermethylation in colorectal cancer cell lines and in early stages of colorectal neoplasia tissue.
WNT5A (show WNT5A Antibodies) and ROR2 are induced by inflammatory mediators through NF-kB and STAT3 (show STAT3 Antibodies) transcription factors, and are involved in the migration of human ovarian cancer cell line SKOV-3.
On these bases, we identified that miR (show MLXIP Antibodies)-208b targets receptor tyrosine kinase-like orphan receptor 2 gene by which miR (show MLXIP Antibodies)-208b can regulate the development of osteosarcoma.
Our findings suggest that receptor tyrosine kinase-like orphan receptor 2 may be an important regulator of epithelial-mesenchymal transition, primarily regulated the non-canonical Wnt (show WNT2 Antibodies) signaling pathway in ovarian cancer cells, and may display a promising therapeutic target for ovarian cancer.
Knockdown of Ror2 expression in renal cell carcinoma (show MOK Antibodies) cells significantly reduced cell proliferation and induced apoptosis.
found no association between ROR2 staining and poor patient survival
Data show that CD13 (show ANPEP Antibodies) anntigen and receptor tyrosine kinase-like orphan receptor 2 (ROR2) identify a cardiac lineage precursor pool that is capable of successful engraftment into the porcine heart.
ROR2 gene mutations are associated with autosomal recessive robinow syndrome.
results corroborated previous findings of Ryk (show RYK Antibodies)-mediated Wnt5a (show WNT5A Antibodies) effect, and suggested a role for Ror2 in the Wnt5a (show WNT5A Antibodies) machinery in glioblastoma
we uncovered cell state plasticity and adhesion dynamics regulated by Ror2, which influenced Ras Homology Family Member A (show CXCL14 Antibodies) (RhoA (show RHOA Antibodies)) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1 (show ROCK1 Antibodies)) activity downstream of Dishevelled-2 (Dvl2 (show DVL2 Antibodies)).
Here, the study of two Ror2 mutants connects aberrant germ cell migration to defects in meiosis and supports the diffusion model of meiotic entry.
Although Ror1 (show ROR1 Antibodies)-mutant mice show no apparent defects in ureteric bud (UB) formation, Ror1 (show ROR1 Antibodies); Ror2-double-mutant mice exhibit either defects in UB outgrowth and branching morphogenesis, associated with the loss of the MM from the UB domain, or ectopic formation of the UB.
The Wnt5a (show WNT5A Antibodies)-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-gamma (show IFNG Antibodies) in colitis
Non-canonical Wnt5a (show WNT5A Antibodies)/Ror2 signaling regulates kidney morphogenesis by controlling intermediate mesoderm extension.
Ror2 plays an important role in mammary gland development in mice.
The activation of Wnt5a (show WNT5A Antibodies)-Ror2 signaling in epithelial cells undergoing epithelial-to-mesenchymal transition (EMT (show ITK Antibodies)) may play an important role in disrupting TBM via MMP-2 (show MMP2 Antibodies) induction during renal fibrosis.
The results indicate an important role of Wnt5a (show WNT5A Antibodies)-Ror2 signaling in morphogenesis of the metanephric mesenchyme to ensure proper epithelial tubular formation of the ureteric bud required for kidney development.
This study provides a method to investigate the effects of the Wnt (show WNT2 Antibodies) pathway on the fate of mesenchymal stem cells (MSC (show MSC Antibodies)) in vivo and for the further improvement of MSC (show MSC Antibodies)-based therapies.
Show Ror2 expression is higher in highly metastatic cell line than in low metastatic variant cell line. Our data show that Ror2 is a potential factor in the tumorigenesis and metastasis in a Src (show SRC Antibodies)-dependent manner that is negatively regulated by NRAGE (show MAGED1 Antibodies).
The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.
neurotrophic tyrosine kinase receptor-related 2
, tyrosine-protein kinase transmembrane receptor ROR2
, neurotrophic tyrosine kinase, receptor related 2
, neurotrophic tyrosine kinase, receptor-related 2
, receptor tyrosine kinase-like orphan receptor 2
, tyrosine-protein kinase transmembrane receptor ROR2-like
, LOW QUALITY PROTEIN: tyrosine-protein kinase transmembrane receptor ROR2
, receptor tyrosine kinase Xror2
, receptor tyrosine kinase like orphan receptor 2 L homeolog
, receptor tyrosine kinase-like orphan receptor 2 L homeolog