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|Antigen||SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Antibodies|
|Epitope||AA 385-495 Alternatives|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This SHC1 antibody is un-conjugated Alternatives|
ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Western Blotting (WB)
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Product Details anti-SHC1 AntibodyTarget Details SHC1 Application Details Handling Images
|Purpose||Purified Mouse Monoclonal Antibody|
Dynactin 4 could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.The dynactin complex binds cargo, such as vesicles and organelles, to cytoplasmic dynein for retrograde microtubule-mediated trafficking and could feasibly be involved in the copper-regulated trafficking of ATP7B. ,.
Synonyms: SHC-transforming protein 1, SHC-transforming protein 3, SHC-transforming protein A, Src homology 2 domain-containing-transforming protein C1, SH2 domain protein C1, SHC1, SHC, SHCA
Immunogen: Purified recombinant fragment of human SHC1 (AA: 385-495) expressed in E. Coli.
Antigen Type: Recombinant Protein
|Plasmids, Primers & others|
Target Details SHC1Product Details anti-SHC1 Antibody Application Details Handling Images back to top
|Alternative Name||SHC1 (SHC1 Antibody Abstract)|
Other Names: SHC-transforming protein 1, SHC-transforming protein 3, SHC-transforming protein A, Src homology 2 domain-containing-transforming protein C1, SH2 domain protein C1, SHC1, SHC, SHCA
Description: This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
|Pathways||RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, ER-Nucleus Signaling, Signaling Events mediated by VEGFR1 and VEGFR2|
Application DetailsProduct Details anti-SHC1 Antibody Target Details SHC1 Handling Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-SHC1 Antibody Target Details SHC1 Application Details Images back to top
|Buffer||Purified antibody in PBS with 0.05 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
ImagesProduct Details anti-SHC1 Antibody Target Details SHC1 Application Details Handling back to top