anti-Human SHC1 antibody for Flow Cytometry

Recommended SHC1 Antibody (supplied by: Log in to see )

Antigen
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Antibodies
  • SHC1
  • SHC
  • SHCA
  • P66shc
  • si:dkey-246i14.4
  • wu:fc10h03
  • shc
  • p66shc
  • Shc
  • ShcA
  • p66
  • SHC adaptor protein 1
  • Shc1p
  • squalene--hopene cyclase
  • SHC (Src homology 2 domain containing) transforming protein 1
  • SHC (Src homology 2 domain containing) transforming protein 1 L homeolog
  • src homology 2 domain-containing transforming protein C1
  • SHC1
  • shc1
  • Shc1
  • shc1.L
Epitope
AA 385-495
48
48
21
19
15
15
13
10
8
8
7
6
6
6
4
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
268
204
158
6
6
2
1
1
1
1
1
1
Host
Mouse
246
34
Clonality
Monoclonal
Conjugate
This SHC1 antibody is un-conjugated
8
8
7
5
5
5
5
5
5
5
5
5
5
5
1
1
1
1
Application
ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Western Blotting (WB)
201
102
77
67
66
46
18
16
11
7
7
4
1
1
Options
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Catalog No. ABIN4881246
$ 561.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
13.821003 ABIN2731992 FACS IF WB Mouse IgG1 Log in to see 3H1 0
13.821003 ABIN5542463 ELISA FACS ICC WB Mouse IgG1 AA 385-495 Log in to see 2F7C7 0
1 ABIN2731990 FACS IF WB Mouse IgG1 Log in to see 1D3 0
1 ABIN6248385 FACS ICC IF WB Mouse IgG1 Log in to see OTI1D3 0
1 ABIN6248388 FACS ICC IF WB Mouse IgG1 Log in to see OTI3H1 0
1 ABIN5954253 ELISA FACS ICC WB Mouse IgG1 Log in to see 2F7C7 0
1 ABIN2151536 FACS IF WB Mouse IgG1 Log in to see 3H1 0

General

Antigen SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Antibodies
Epitope AA 385-495
(48), (48), (21), (19), (15), (15), (13), (10), (8), (8), (7), (6), (6), (6), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine)
(268), (204), (158), (6), (6), (2), (1), (1), (1), (1), (1), (1)
Host Mouse
(246), (34)
Clonality (Clone)
Monoclonal   ( )
Conjugate This SHC1 antibody is un-conjugated
(8), (8), (7), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (1), (1), (1), (1)
Application ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Western Blotting (WB)
(201), (102), (77), (67), (66), (46), (18), (16), (11), (7), (7), (4), (1), (1)
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Product Details anti-SHC1 Antibody

Target Details SHC1 Application Details Handling Images
Purpose Purified Mouse Monoclonal Antibody
Characteristics Dynactin 4 could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.The dynactin complex binds cargo, such as vesicles and organelles, to cytoplasmic dynein for retrograde microtubule-mediated trafficking and could feasibly be involved in the copper-regulated trafficking of ATP7B. ,.

Synonyms: SHC-transforming protein 1, SHC-transforming protein 3, SHC-transforming protein A, Src homology 2 domain-containing-transforming protein C1, SH2 domain protein C1, SHC1, SHC, SHCA
Purification Purified
Immunogen

Immunogen: Purified recombinant fragment of human SHC1 (AA: 385-495) expressed in E. Coli.

Antigen Type: Recombinant Protein

Clone 2F7C7
Isotype IgG1
Plasmids, Primers & others

Target Details SHC1

Product Details anti-SHC1 Antibody Application Details Handling Images back to top
Antigen
Alternative Name SHC1 (SHC1 Antibody Abstract)
Background

Other Names: SHC-transforming protein 1, SHC-transforming protein 3, SHC-transforming protein A, Src homology 2 domain-containing-transforming protein C1, SH2 domain protein C1, SHC1, SHC, SHCA

Description: This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.

Molecular Weight 62822
Gene ID 6464
UniProt P29353
Pathways RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, ER-Nucleus Signaling, Signaling Events mediated by VEGFR1 and VEGFR2

Application Details

Product Details anti-SHC1 Antibody Target Details SHC1 Handling Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-SHC1 Antibody Target Details SHC1 Application Details Images back to top
Format Liquid
Buffer Purified antibody in PBS with 0.05 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Images

Product Details anti-SHC1 Antibody Target Details SHC1 Application Details Handling back to top
Supplier Images
ELISA image for anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 385-495) antibody (ABIN4881246) Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (5...
Western Blotting (WB) image for anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 385-495) antibody (ABIN4881246) Figure 1: Western blot analysis using SHC1 mAb against human SHC1 (AA: 385-495) recom...
Western Blotting (WB) image for anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 385-495) antibody (ABIN4881246) Figure 2: Western blot analysis using SHC1 mAb against HEK293 (1) and SHC1 (AA: 385-4...
Western Blotting (WB) image for anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 385-495) antibody (ABIN4881246) Figure 3: Western blot analysis using SHC1 mouse mAb against NIH/3T3 cell lysate. Dil...
Immunofluorescence (IF) image for anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 385-495) antibody (ABIN4881246) Figure 4: Immunofluorescence analysis of A431 cells using SHC1 mouse mAb (green). Blu...
Flow Cytometry (FACS) image for anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 385-495) antibody (ABIN4881246) Figure 5: Flow cytometric analysis of NIH/3T3 cells using SHC1 mouse mAb (green) and ...