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|Antigen||TEK Tyrosine Kinase, Endothelial (TEK) Antibodies|
|Epitope||Extracellular Domain Alternatives|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This TEK antibody is un-conjugated Alternatives|
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
|4 references available|
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Product Details anti-TEK AntibodyTarget Details TEK Application Details Handling References for anti-TEK antibody (ABIN967565) Images
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Please refer to us for technical protocols.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Immunogen||Human TIE2 extracellular domain Recombinant Protein|
Target Details TEKProduct Details anti-TEK Antibody Application Details Handling References for anti-TEK antibody (ABIN967565) Images back to top
|Alternative Name||TIE2 (TEK Antibody Abstract)|
|Background||The TIE receptor family is a member of the class of receptors called the receptor tyrosine kinases (RKT). RKTs are cell surface receptors which also contain a protein kinase domain in their intracellular portion and upon binding of their specific growth factor, initiate a series of downstream biological events. TIE receptors, designated Tie1 and Tie2 (Tek) have a tissue distribution which is limited primarily to cells of endothelial origin. Tie2 has been shown to be required for the normal development of vascular structures during embryogenesis. It has also been demonstrated to play a role in normal and pathological angiogenesis in adults. Tie2 has a predicted molecular weight of 126 kD, but may be observable at ~130-165 kDa. This antibody has been reported to recognize human and mouse Tie2 but not Tie1.|
|Molecular Weight||130-165 kDa|
|Pathways||RTK Signaling, Growth Factor Binding|
Application DetailsProduct Details anti-TEK Antibody Target Details TEK Handling References for anti-TEK antibody (ABIN967565) Images back to top
Related Products: ABIN967389, ABIN968537
|Restrictions||For Research Use only|
HandlingProduct Details anti-TEK Antibody Target Details TEK Application Details References for anti-TEK antibody (ABIN967565) Images back to top
|Buffer||Aqueous buffered solution containing ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at 4°C.|
References for anti-TEK antibody (ABIN967565)Product Details anti-TEK Antibody Target Details TEK Application Details Handling Images back to top
|Product cited in:||
Partanen, Dumont: "Functions of Tie1 and Tie2 receptor tyrosine kinases in vascular development." in: Current topics in microbiology and immunology, Vol. 237, Issue 4, pp. 159-72, 1999
Peters, Coogan, Berry, Marks, Iglehart, Kontos, Rao, Sankar, Trogan: "Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis." in: British journal of cancer, Vol. 77, Issue 1, pp. 51-6, 1998
Wong, Haroon, Werner, Dewhirst, Greenberg, Peters: "Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues." in: Circulation research, Vol. 81, Issue 4, pp. 567-74, 1997
Dumont, Gradwohl, Fong, Puri, Gertsenstein, Auerbach, Breitman: "Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo." in: Genes & development, Vol. 8, Issue 16, pp. 1897-909, 1994
ImagesProduct Details anti-TEK Antibody Target Details TEK Application Details Handling References for anti-TEK antibody (ABIN967565) back to top