anti-Human TRKA antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended TRKA Antibody (supplied by: Log in to see )

Antigen
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) Antibodies
  • MTC
  • TRK
  • TRK1
  • TRKA
  • Trk-A
  • p140-TrkA
  • Trk
  • C80751
  • Tkr
  • TrkA
  • trk
  • trka
  • CTRKA
  • trkA
  • neurotrophic receptor tyrosine kinase 1
  • neurotrophic tyrosine kinase, receptor, type 1
  • NTRK1
  • Ntrk1
  • ntrk1
Epitope
AA 480-520, pTyr496
57
22
19
18
17
16
15
15
14
13
13
12
12
11
11
10
10
10
9
9
8
7
7
6
6
5
5
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
412
244
199
2
2
Host
Rabbit
375
62
4
3
3
Clonality
Polyclonal
Conjugate
This TRKA antibody is un-conjugated
17
15
15
10
9
9
9
8
8
8
8
7
7
7
7
7
6
2
2
2
2
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
261
147
89
87
57
56
53
41
18
12
5
5
4
3
2
1
Options
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Catalog No. ABIN746603
$ 328.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN726110 IF (p) IHC (p) WB Rabbit IgG AA 740-796 Log in to see Polyclonal 1
1 ABIN746618 IF (p) IHC (p) WB Rabbit IgG pTyr674, pTyr675 Log in to see Polyclonal 0
1 ABIN703330 IF (p) IHC (p) WB Rabbit IgG pTyr817 Log in to see Polyclonal 1
1 ABIN726095 IF (p) IHC (p) WB Rabbit IgG AA 640-676 Log in to see Polyclonal 0
1 ABIN746609 IF (p) Cy7 Rabbit IgG AA 480-520, pTyr496 Log in to see Polyclonal 0
1 ABIN746607 IF (p) Cy5 Rabbit IgG AA 480-520, pTyr496 Log in to see Polyclonal 0
1 ABIN746608 IF (p) Cy5.5 Rabbit IgG AA 480-520, pTyr496 Log in to see Polyclonal 0
1 ABIN746606 IF (p) Cy3 Rabbit IgG AA 480-520, pTyr496 Log in to see Polyclonal 0
1 ABIN746610 IF (p) FITC Rabbit IgG AA 480-520, pTyr496 Log in to see Polyclonal 0
1 ABIN879811 IF (p) Alexa Fluor 350 Rabbit IgG AA 480-520, pTyr496 Log in to see Polyclonal 0
1 ABIN879813 IF (p) Alexa Fluor 555 Rabbit IgG AA 480-520, pTyr496 Log in to see Polyclonal 0
1 ABIN879814 IF (p) Alexa Fluor 488 Rabbit IgG AA 480-520, pTyr496 Log in to see Polyclonal 0
1 ABIN879815 IF (p) Alexa Fluor 647 Rabbit IgG AA 480-520, pTyr496 Log in to see Polyclonal 0
1 ABIN918689 IF (p) Alexa Fluor 647 Rabbit IgG AA 740-796 Log in to see Polyclonal 0
1 ABIN918686 IF (p) Alexa Fluor 488 Rabbit IgG AA 740-796 Log in to see Polyclonal 0
1 ABIN918687 IF (p) Alexa Fluor 555 Rabbit IgG AA 740-796 Log in to see Polyclonal 0
1 ABIN918688 IF (p) Alexa Fluor 350 Rabbit IgG AA 740-796 Log in to see Polyclonal 0
1 ABIN746621 IF (p) Cy3 Rabbit IgG pTyr674, pTyr675 Log in to see Polyclonal 0
1 ABIN746623 IF (p) Cy5.5 Rabbit IgG pTyr674, pTyr675 Log in to see Polyclonal 0
1 ABIN746622 IF (p) Cy5 Rabbit IgG pTyr674, pTyr675 Log in to see Polyclonal 0

General

Antigen Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) Antibodies
Epitope AA 480-520, pTyr496
(57), (22), (19), (18), (17), (16), (15), (15), (14), (13), (13), (12), (12), (11), (11), (10), (10), (10), (9), (9), (8), (7), (7), (6), (6), (5), (5), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine)
(412), (244), (199), (2), (2)
Host Rabbit
(375), (62), (4), (3), (3)
Clonality
Polyclonal
Conjugate This TRKA antibody is un-conjugated
(17), (15), (15), (10), (9), (9), (9), (8), (8), (8), (8), (7), (7), (7), (7), (7), (6), (2), (2), (2), (2), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(261), (147), (89), (87), (57), (56), (53), (41), (18), (12), (5), (5), (4), (3), (2), (1)
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Product Details anti-TRKA Antibody

Target Details TRKA Application Details Handling Images
Specificity This antibody will recognize TrkB when phosphorylated at Tyr516 and TrkC when phosphorylated at Tyr516
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human TrkA around the phosphorylation site of Tyr496
Isotype IgG

Target Details TRKA

Product Details anti-TRKA Antibody Application Details Handling Images back to top
Antigen
Alternative Name Trka (NTRK1 Antibody Abstract)
Background

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.

Subcellular location: Cytoplasm

Synonyms: High affinity nerve growth factor receptor, Neurotrophic tyrosine kinase receptor type 1, TRK1-transforming tyrosine kinase protein, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, Trk-A, gp140trk, p140-TrkA, NTRK1, MTC, TRK, TRKA

Gene ID 4914
UniProt P04629
Pathways RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process

Application Details

Product Details anti-TRKA Antibody Target Details TRKA Handling Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-TRKA Antibody Target Details TRKA Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-TRKA Antibody Target Details TRKA Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 480-520), (pTyr496) antibody (ABIN746603) Formalin-fixed and paraffin embedded mouse lung labeled with Rabbit Anti Phospho-TrkA...
Immunohistochemistry (IHC) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 480-520), (pTyr496) antibody (ABIN746603) Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-Phospho-TrkA ...
SDS-PAGE (SDS) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 480-520), (pTyr496) antibody (ABIN746603) Lane 1: mouse liver lysates Lane 2: mouse lung lysates probed with Anti Phospho-TrkA ...