anti-Human TRKA antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended TRKA Antibody (supplied by: Log in to see )

Antigen
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) Antibodies
  • MTC
  • TRK
  • TRK1
  • TRKA
  • Trk-A
  • p140-TrkA
  • Trk
  • C80751
  • Tkr
  • TrkA
  • trk
  • trka
  • CTRKA
  • trkA
  • neurotrophic receptor tyrosine kinase 1
  • neurotrophic tyrosine kinase, receptor, type 1
  • NTRK1
  • Ntrk1
  • ntrk1
Epitope
AA 740-796
56
26
22
17
15
15
15
14
14
13
13
12
12
12
12
11
10
10
10
10
8
7
7
6
6
5
5
4
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
440
270
216
2
2
Host
Rabbit
408
58
4
3
1
Clonality
Polyclonal
Conjugate
This TRKA antibody is un-conjugated
17
16
16
10
9
9
9
8
8
8
8
7
7
7
7
7
6
2
2
2
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
277
176
122
87
65
56
54
40
19
12
9
5
4
1
1
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

Submit your validation data for this product and get a full refund. I want to validate this product

Learn more

Available images

Catalog No. ABIN726110
$ 318.45
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
10.879798 ABIN5947441 ICC IF IHC IHC (p) WB Rabbit IgG C-Term Log in to see JJ084-04 0
10.879798 ABIN5947442 FACS ICC IF IHC IHC (p) IP WB Rabbit IgG AA 750-850 Log in to see SU0354 0
10.879798 ABIN703330 IF (p) IHC (p) WB Rabbit IgG pTyr817 Log in to see Polyclonal 1
10.879798 ABIN337137 IHC IHC (p) IP WB Rabbit Log in to see Polyclonal 0
10.879798 ABIN1715057 IF (p) IHC (p) WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN3044367 IHC (p) WB Rabbit IgG AA 342-361, Middle Region Log in to see Polyclonal 2
1 ABIN746603 IF (p) IHC (p) WB Rabbit IgG AA 480-520, pTyr496 Log in to see Polyclonal 0
1 ABIN127050 IHC (p) IP WB Rabbit Log in to see Polyclonal 2
1 ABIN746618 IF (p) IHC (p) WB Rabbit IgG pTyr674, pTyr675 Log in to see Polyclonal 0
1 ABIN271917 IF IHC (p) Rabbit Log in to see Polyclonal 0
1 ABIN372776 IHC (p) IP WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN726095 IF (p) IHC (p) WB Rabbit IgG AA 640-676 Log in to see Polyclonal 0
1 ABIN1998165 IHC (p) Rabbit IgG AA 1-382 Log in to see 024 0
1 ABIN1959897 IHC IHC (p) WB Mouse IgG1, kappa Log in to see 0
1 ABIN272088 EIA IHC (p) WB Rabbit Log in to see Polyclonal 0
1 ABIN746612 IHC (p) WB HRP Rabbit IgG AA 480-520, pTyr496 Log in to see Polyclonal 0
1 ABIN6284036 ELISA IHC (p) WB Rabbit IgG AA 440-520 Log in to see Polyclonal 0
1 ABIN6288383 ELISA IHC (p) WB Rabbit IgG AA 640-720, pTyr701 Log in to see Polyclonal 0
1 ABIN6288397 ELISA IHC (p) Rabbit IgG AA 700-780, pTyr757 Log in to see Polyclonal 0
1 ABIN6288408 ELISA IHC (p) Rabbit IgG AA 720-800, pTyr791 Log in to see Polyclonal 0

General

Antigen Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) Antibodies
Epitope AA 740-796
(56), (26), (22), (17), (15), (15), (15), (14), (14), (13), (13), (12), (12), (12), (12), (11), (10), (10), (10), (10), (8), (7), (7), (6), (6), (5), (5), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(440), (270), (216), (2), (2)
Host Rabbit
(408), (58), (4), (3), (1)
Clonality
Polyclonal
Conjugate This TRKA antibody is un-conjugated
(17), (16), (16), (10), (9), (9), (9), (8), (8), (8), (8), (7), (7), (7), (7), (7), (6), (2), (2), (2), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(277), (176), (122), (87), (65), (56), (54), (40), (19), (12), (9), (5), (4), (1), (1), (1)
Pubmed 1 reference available
Supplier Log in to see

Product Details anti-TRKA Antibody

Target Details TRKA Application Details Handling References for anti-TRKA antibody (ABIN726110) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human Trk A
Isotype IgG
Plasmids, Primers & others

Target Details TRKA

Product Details anti-TRKA Antibody Application Details Handling References for anti-TRKA antibody (ABIN726110) Images back to top
Antigen
Alternative Name TrkA (NTRK1 Antibody Abstract)
Background

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.

Subcellular location: Cytoplasm

Synonyms: MTC, TRK, TRK1, TRKA, Trk-A, p14-TrkA, High affinity nerve growth factor receptor, Neurotrophic tyrosine kinase receptor type 1, TRK1-transforming tyrosine kinase protein, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, gp14trk, NTRK1

Gene ID 4914
UniProt P04629
Pathways RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process

Application Details

Product Details anti-TRKA Antibody Target Details TRKA Handling References for anti-TRKA antibody (ABIN726110) Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-TRKA Antibody Target Details TRKA Application Details References for anti-TRKA antibody (ABIN726110) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

References for anti-TRKA antibody (ABIN726110)

Product Details anti-TRKA Antibody Target Details TRKA Application Details Handling Images back to top
Product cited in:

Li, Shen, Di, Li, Geng, Lu, He: "Biological and clinical significance of p75NTR expression in laryngeal squamous epithelia and laryngocarcinoma." in: Acta oto-laryngologica, Vol. 132, Issue 3, pp. 314-24, 2012 Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Human). Further details: Sample: primary T1�T4 LSCC

Images

Product Details anti-TRKA Antibody Target Details TRKA Application Details Handling References for anti-TRKA antibody (ABIN726110) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 740-796) antibody (ABIN726110) Formalin-fixed and paraffin embedded: human endometrium Anti-TrK-A/NTRK1 Polyclonal A...
 image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 740-796) antibody (ABIN726110) U251 lysates probed with TrkA Polyclonal Antibody, Unconjugated at 1:300 dilution an...
Western Blotting (WB) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 740-796) antibody (ABIN726110) Lane 1: mouse lymph node lysates Lane 2: rat Lymph node lysates probed with TrkA Poly...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 740-796) antibody (ABIN726110) Paraformaldehyde-fixed, paraffin embedded Mouse Brain Antigen retrieval by boiling in...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 740-796) antibody (ABIN726110) Paraformaldehyde-fixed, paraffin embedded (Mouse Brain) Antigen retrieval by boiling ...