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|Antigen||Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) Antibodies|
|Epitope||AA 71-90, N-Term Alternatives|
|Conjugate||This TRKA antibody is un-conjugated Alternatives|
Western Blotting (WB)
|2 references available|
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Product Details anti-TRKA AntibodyTarget Details TRKA Application Details Handling References for anti-TRKA antibody (ABIN3042872) Images
|Purpose||Rabbit IgG polyclonal antibody for High affinity nerve growth factor receptor(NTRK1) detection. Tested with WB in Human.|
|Cross-Reactivity (Details)||No cross reactivity with other proteins.|
Rabbit IgG polyclonal antibody for High affinity nerve growth factor receptor(NTRK1) detection. Tested with WB in Human.
Gene Name: neurotrophic tyrosine kinase, receptor, type 1
Protein Name: High affinity nerve growth factor receptor
|Purification||Immunogen affinity purified.|
|Immunogen||A synthetic peptide corresponding to a sequence at the N-terminus of human TrkA(71-90aa LYIENQQHLQHLELRDLRGL).|
Target Details TRKAProduct Details anti-TRKA Antibody Application Details Handling References for anti-TRKA antibody (ABIN3042872) Images back to top
|Alternative Name||NTRK1 (NTRK1 Antibody Abstract)|
Neurotrophic tyrosine kinase receptor type 1, also called Trk-A, is a protein that in humans is encoded by the NTRK1 gene. The NTKR1 gene encodes the neurotrophic tyrosine kinase-1 receptor and belongs to a family of nerve growth factor receptors whose ligands include neurotrophins. This gene is mapped to 1q23.1. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.
Synonyms: CIPA antibody|DKFZp781I14186 antibody|gp140trk antibody|High affinity nerve growth factor receptor antibody|High affinity nerve growth factor receptor precursor antibody|MTC antibody|Neurotrophic tyrosine kinase receptor type 1 antibody|Ntrk 1 antibody|Ntrk1 antibody|NTRK1_HUMAN antibody|Oncogene TRK antibody|p140 TrkA antibody|p140-TrkA antibody|TRK 1 antibody|Trk A antibody|TRK antibody|Trk-A antibody|TRK1 antibody|TRK1 transforming tyrosine kinase protein antibody|TRK1-transforming tyrosine kinase protein antibody|Tropomyosin-related kinase A antibody|Tyrosine kinase receptor A antibody|Tyrosine kinase receptor antibody|Tyrosine Receptor Kinase A antibody
|Pathways||RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process|
Application DetailsProduct Details anti-TRKA Antibody Target Details TRKA Handling References for anti-TRKA antibody (ABIN3042872) Images back to top
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.
Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
|Restrictions||For Research Use only|
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|Reconstitution||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|Buffer||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.|
|Preservative||Thimerosal (Merthiolate), Sodium azide|
|Precaution of Use||This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
|Expiry Date||12 months|
References for anti-TRKA antibody (ABIN3042872)Product Details anti-TRKA Antibody Target Details TRKA Application Details Handling Images back to top
|Product cited in:||
Li, Ma, Yi, Wang, Li, Liu, Sun, Chen, Yu, Li, Chen, Zhou: "The interactions between nerve growth factor and gonadotrophins in bovine oviduct." in: Animal reproduction science, Vol. 149, Issue 3-4, pp. 117-23, 2014
Li, Zhang, Zou, Xia, Bao: "Accumulation of nerve growth factor and its receptors in the uterus and dorsal root ganglia in a mouse model of adenomyosis." in: Reproductive biology and endocrinology : RB&E, Vol. 9, pp. 30, 2011
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