anti-Human TRKA antibody for Western Blotting

Recommended TRKA Antibody (supplied by: Log in to see )

Antigen
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) Antibodies
  • MTC
  • TRK
  • TRK1
  • TRKA
  • Trk-A
  • p140-TrkA
  • Trk
  • C80751
  • Tkr
  • TrkA
  • trk
  • trka
  • CTRKA
  • trkA
  • neurotrophic receptor tyrosine kinase 1
  • neurotrophic tyrosine kinase, receptor, type 1
  • NTRK1
  • Ntrk1
  • ntrk1
Epitope
pTyr680, pTyr681
55
25
19
17
15
15
15
13
13
13
12
12
12
12
10
10
10
10
10
8
7
7
6
6
6
5
5
4
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
423
260
206
2
2
Host
Rabbit
396
52
4
3
2
Clonality
Polyclonal
Conjugate
This TRKA antibody is un-conjugated
17
16
16
10
9
8
8
8
7
7
7
7
7
7
7
7
6
2
2
1
1
1
Application
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
274
166
122
88
59
53
48
40
19
12
9
5
4
1
1
1
Supplier
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Catalog No. ABIN6256787
$ 390.77
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
24.075909 ABIN969444 ICC ELISA WB Mouse IgG1 AA 33-423 Log in to see 6B2 2
24.075909 ABIN931339 IF ELISA WB Mouse IgG1 AA 33-423 Log in to see 6B2 1
21.297693 ABIN726110 IF (p) IHC (p) WB Rabbit IgG AA 740-796 Log in to see Polyclonal 1
19.797693 ABIN4900238 CyTOF FACS IHC Neut WB Goat IgG AA 33-407 Log in to see Polyclonal 6
19.797693 ABIN1873972 IHC WB Rabbit IgG Log in to see Polyclonal 0
17.278215 ABIN967209 IHC (p) WB Rabbit IgG Middle Region Log in to see Polyclonal 3
17.278215 ABIN284787 ELISA WB Mouse IgG2b Extracellular Domain Log in to see TrKA 1
16.575909 ABIN1574102 ELISA WB Rabbit IgG C-Term Log in to see Polyclonal 0
16.575909 ABIN1574101 ELISA WB Rabbit IgG AA 350-400 Log in to see Polyclonal 0
16.575909 ABIN3022909 IHC WB Rabbit IgG Log in to see Polyclonal 0
16.575909 ABIN3015035 ICC FACS IP IHC WB Rabbit Log in to see Polyclonal 0
13.797692 ABIN6269783 ELISA IHC WB Rabbit IgG pTyr791 Log in to see Polyclonal 0
12.778215 ABIN351063 IHC WB Rabbit IgG Extracellular Domain Log in to see Polyclonal 10
12.778215 ABIN351062 IHC WB Rabbit Extracellular Domain Log in to see Polyclonal 10
12.778215 ABIN4902393 ELISA IF WB Mouse IgG1 AA 33-423 Log in to see 6B2 0
12.778215 ABIN3182658 ELISA IHC WB Rabbit IgG pTyr701 Log in to see Polyclonal 0
12.778215 ABIN3187343 ELISA IHC WB Rabbit IgG Thr172, Thr183 Log in to see Polyclonal 0
12.778215 ABIN3182313 ELISA WB Rabbit IgG pTyr680, pTyr681 Log in to see Polyclonal 0
12.778215 ABIN5621443 ELISA WB Rabbit IgG Tyr496 Log in to see Polyclonal 0
12.778215 ABIN2153846 IF IP WB Rabbit IgG pTyr490 Log in to see Polyclonal 0

General

Antigen Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) Antibodies
Epitope pTyr680, pTyr681
(55), (25), (19), (17), (15), (15), (15), (13), (13), (13), (12), (12), (12), (12), (10), (10), (10), (10), (10), (8), (7), (7), (6), (6), (6), (5), (5), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(423), (260), (206), (2), (2)
Host Rabbit
(396), (52), (4), (3), (2)
Clonality
Polyclonal
Conjugate This TRKA antibody is un-conjugated
(17), (16), (16), (10), (9), (8), (8), (8), (7), (7), (7), (7), (7), (7), (7), (7), (6), (2), (2), (1), (1), (1)
Application ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
(274), (166), (122), (88), (59), (53), (48), (40), (19), (12), (9), (5), (4), (1), (1), (1)
Pubmed 1 reference available
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Product Details anti-TRKA Antibody

Target Details TRKA Application Details Handling References for anti-TRKA antibody (ABIN6256787) Images
Specificity Phospho-Trk A (Tyr680+Tyr681) Antibody detects endogenous levels of Trk A only when phosphorylated at Tyrosine 680+Tyrosine 681
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Purification The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Immunogen A synthesized peptide derived from human Trk A around the phosphorylation site of Tyrosine 680+Tyrosine 681
Isotype IgG
Plasmids, Primers & others

Target Details TRKA

Product Details anti-TRKA Antibody Application Details Handling References for anti-TRKA antibody (ABIN6256787) Images back to top
Antigen
Alternative Name Trk A (NTRK1 Antibody Abstract)
Background

Description: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubMed:1849459, PubMed:1281417, PubMed:8325889, PubMed:15488758, PubMed:17196528, PubMed:27445338). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.

Gene: NTRK1

Molecular Weight 87kDa
Gene ID 4914
UniProt P04629
Pathways RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process

Application Details

Product Details anti-TRKA Antibody Target Details TRKA Handling References for anti-TRKA antibody (ABIN6256787) Images back to top
Application Notes WB 1:500-1:2000 IHC 1:50-1:500
Restrictions For Research Use only

Handling

Product Details anti-TRKA Antibody Target Details TRKA Application Details References for anti-TRKA antibody (ABIN6256787) Images back to top
Format Liquid
Concentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20 °C.Stable for 12 months from date of receipt
Expiry Date 12 months

References for anti-TRKA antibody (ABIN6256787)

Product Details anti-TRKA Antibody Target Details TRKA Application Details Handling Images back to top
Product cited in:

Liu, Geng, Zhang, Wang, Zhang, Duan, Zhang: "Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway." in: Marine drugs, Vol. 16, Issue 3, 2018

Images

Product Details anti-TRKA Antibody Target Details TRKA Application Details Handling References for anti-TRKA antibody (ABIN6256787) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pTyr680), (pTyr681) antibody (ABIN6256787) ABIN6267286 at 1/100 staining mouse kidney tissue sections by IHC-P. The tissue was f...
Immunohistochemistry (IHC) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pTyr680), (pTyr681) antibody (ABIN6256787) ABIN6267286 at 1/100 staining mouse spleen tissue sections by IHC-P. The tissue was f...
Immunohistochemistry (IHC) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pTyr680), (pTyr681) antibody (ABIN6256787) ABIN6267286 at 1/100 staining mouse lung tissue sections by IHC-P. The tissue was for...
Immunohistochemistry (IHC) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pTyr680), (pTyr681) antibody (ABIN6256787) ABIN6267286 at 1/100 staining human heart tissue sections by IHC-P. The tissue was fo...
Immunohistochemistry (IHC) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pTyr680), (pTyr681) antibody (ABIN6256787) ABIN6267286 at 1/100 staining human liver tissue sections by IHC-P. The tissue was fo...
Immunohistochemistry (IHC) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pTyr680), (pTyr681) antibody (ABIN6256787) ABIN6267286 at 1/100 staining human lung cancer tissue sections by IHC-P. The tissue ...
Immunohistochemistry (IHC) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pTyr680), (pTyr681) antibody (ABIN6256787) ABIN6267286 at 1/100 staining rat uterine tissue sections by IHC-P. The tissue was fo...
Immunohistochemistry (IHC) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pTyr680), (pTyr681) antibody (ABIN6256787) ABIN6267286 at 1/100 staining rat brain tissue sections by IHC-P. The tissue was form...
Immunohistochemistry (IHC) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pTyr680), (pTyr681) antibody (ABIN6256787) ABIN6267286 at 1/100 staining rat ovarian tissue sections by IHC-P. The tissue was fo...
Immunohistochemistry (IHC) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pTyr680), (pTyr681) antibody (ABIN6256787) ABIN6267286 at 1/100 staining rat intestinal tissue sections by IHC-P. The tissue was...
Western Blotting (WB) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pTyr680), (pTyr681) antibody (ABIN6256787) Western blot analysis of Trk A phosphorylation expression in starved treated Jurkat w...