anti-Human TRKB antibody for Immunofluorescence (Cultured Cells)

Recommended TRKB Antibody (supplied by: Log in to see )

Antigen
Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) Antibodies
  • trkb
  • trkb-b
  • xtrkb
  • si:ch211-220b11.1
  • trkB2
  • NTRK2
  • ntrk2
  • gp145-trkb
  • TRKB
  • GP145-TrkB
  • trk-B
  • AI848316
  • C030027L06Rik
  • Tkrb
  • trkB
  • RATTRKB1
  • TRKB1
  • Trk-B
  • TrkB
  • neurotrophic tyrosine kinase, receptor, type 2
  • neurotrophic tyrosine kinase, receptor, type 2b
  • NTRK2
  • ntrk2-b
  • ntrk2b
  • ntrk2-a
  • ntrk2
  • Ntrk2
Epitope
pTyr817
25
25
23
18
17
16
15
13
13
12
10
9
9
8
8
8
6
6
6
6
5
4
3
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
329
196
180
14
13
10
8
8
4
2
1
1
1
1
Host
Rabbit
252
91
16
6
4
1
Clonality
Monoclonal
Conjugate
This TRKB antibody is un-conjugated
7
7
7
7
7
7
5
5
5
5
5
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
247
139
128
82
50
45
27
12
9
7
5
4
2
2
2
1
1
1
1
Options
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Catalog No. ABIN5557345
$ 401.50
Plus shipping costs $45.00

General

Antigen Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) Antibodies
Epitope pTyr817
(25), (25), (23), (18), (17), (16), (15), (13), (13), (12), (10), (9), (9), (8), (8), (8), (6), (6), (6), (6), (5), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(329), (196), (180), (14), (13), (10), (8), (8), (4), (2), (1), (1), (1), (1)
Host Rabbit
(252), (91), (16), (6), (4), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This TRKB antibody is un-conjugated
(7), (7), (7), (7), (7), (7), (5), (5), (5), (5), (5), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(247), (139), (128), (82), (50), (45), (27), (12), (9), (7), (5), (4), (2), (2), (2), (1), (1), (1), (1)
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Product Details anti-TRKB Antibody

Target Details TRKB Application Details Handling Images
Purification Purified by Protein A.
Immunogen Synthetic peptide derived from human TrkB(Y817), around 800-850aa (phospho Y817).
Clone 2A1
Isotype IgG

Target Details TRKB

Product Details anti-TRKB Antibody Application Details Handling Images back to top
Antigen
Alternative Name TrkB (NTRK2 Antibody Abstract)
Background

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.

Synonyms: TRKB, trk-B, GP145-TrkB, BDNF/NT-3 growth factors receptor, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin-related kinase B, NTRK2

Gene ID 4915
UniProt Q16620
Research Area Cancer
Pathways RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Skeletal Muscle Fiber Development, Feeding Behaviour, Dicarboxylic Acid Transport

Application Details

Product Details anti-TRKB Antibody Target Details TRKB Handling Images back to top
Application Notes WB 1:1000-2000
IHC-P 1:50-200
IF(ICC) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-TRKB Antibody Target Details TRKB Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-TRKB Antibody Target Details TRKB Application Details Handling back to top
Supplier Images
Western Blotting (WB) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (pTyr817) antibody (ABIN5557345) Mouse brain lysates, probed with TrkB(Y817) (2A1 ) Monoclonal Antibody at 1:1000 ove...
Immunofluorescence (Cultured Cells) (IF (cc)) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (pTyr817) antibody (ABIN5557345) SH-SY-5Y cells were stained with TrkB(Y817) (2A1 ) Monoclonal Antibody at [1:200] in...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (pTyr817) antibody (ABIN5557345) Paraformaldehyde-fixed, paraffin embedded human kidney, Antigen retrieval by boiling ...