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|Antigen||Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) Antibodies|
|Epitope||AA 156-322 Alternatives|
|Reactivity||Rat (Rattus) Alternatives|
|Conjugate||This TRKB antibody is un-conjugated Alternatives|
BioImaging (BI), Fluorescence Microscopy (FM), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
|7 references available|
|Supplier||Log in to see|
Product Details anti-TRKB AntibodyTarget Details TRKB Application Details Handling References for anti-TRKB antibody (ABIN967745) Images
|Cross-Reactivity||Rat (Rattus), Mouse (Murine)|
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Immunogen||Human TrkB aa. 156-322|
Target Details TRKBProduct Details anti-TRKB Antibody Application Details Handling References for anti-TRKB antibody (ABIN967745) Images back to top
|Alternative Name||TrkB (NTRK2 Antibody Abstract)|
The full-length TrkB gene has been reported to encode for a 145 kDa glycosylated transmembrane tyrosine kinase and neurotrophin receptor. The same gene also has been reported to encode for a 95 kDa glycoprotein that is identical to gp145 [TrkB] at the extracellular domain and transmembrane portion but lacks the intracellular portion. TrkB has been observable in a range of 116-145 kD and 70-95 kD due to various TrkB maturation states, subcellular localizations, and glycosylation states. TrkB belongs to a family of tyrosine kinases that include the TrkA proto-oncogene and TrkC. All have an extracellular ligand-binding domain, a transmembrane region, and intracellular kinase and autophosphorylation domains. TrkB binds the neurotrophins NT3 and NT4/5, as well as brain-derived neurotrophic factor (BDNF), a peptide that helps motor neuron survival and repair. The TrkB tyrosine kinase is activated upon binding to BDNF resulting in autophosphorylation of residues Y670, Y674 and Y675 and the subsequent association of several intracellular proteins like PLCgamma, Shc, and PI3-Kinase. TrkB is widely expressed in cells of neuroepithelium and neural crest origin. Some of these include motor neurons, dopamine-producing neurons, and neurons which release gamma-aminobutyric acid in the substantia nigra, neocortex, and hippocampus. The two TrkB gene products are differentially expressed in regions of the adult brain.
Synonyms: Neurotrophic Tyrosine Kinase Receptor Type 2, NTRK2
|Molecular Weight||116-145 & 70-95 kDa|
|Pathways||RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Skeletal Muscle Fiber Development, Feeding Behaviour, Dicarboxylic Acid Transport|
Application DetailsProduct Details anti-TRKB Antibody Target Details TRKB Handling References for anti-TRKB antibody (ABIN967745) Images back to top
Related Products: ABIN968545, ABIN967389
|Restrictions||For Research Use only|
HandlingProduct Details anti-TRKB Antibody Target Details TRKB Application Details References for anti-TRKB antibody (ABIN967745) Images back to top
|Buffer||Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at -20°C.|
References for anti-TRKB antibody (ABIN967745)Product Details anti-TRKB Antibody Target Details TRKB Application Details Handling Images back to top
|Product cited in:||
Du, Feng, Yang, Lu: "Activity- and Ca(2+)-dependent modulation of surface expression of brain-derived neurotrophic factor receptors in hippocampal neurons." in: The Journal of cell biology, Vol. 150, Issue 6, pp. 1423-34, 2000
Muller, Djebbara-Hannas, Jourdain, Vutskits, Durbec, Rougon, Kiss: "Brain-derived neurotrophic factor restores long-term potentiation in polysialic acid-neural cell adhesion molecule-deficient hippocampus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 8, pp. 4315-20, 2000
Jovanovic, Czernik, Fienberg, Greengard, Sihra: "Synapsins as mediators of BDNF-enhanced neurotransmitter release." in: Nature neuroscience, Vol. 3, Issue 4, pp. 323-9, 2000
Kryl, Yacoubian, Haapasalo, Castren, Lo, Barker: "Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 14, pp. 5823-33, 1999
Armanini, McMahon, Sutherland, Shelton, Phillips: "Truncated and catalytic isoforms of trkB are co-expressed in neurons of rat and mouse CNS." in: The European journal of neuroscience, Vol. 7, Issue 6, pp. 1403-9, 1995
Ebendal: "Function and evolution in the NGF family and its receptors." in: Journal of neuroscience research, Vol. 32, Issue 4, pp. 461-70, 1992
Klein, Conway, Parada, Barbacid: "The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain." in: Cell, Vol. 61, Issue 4, pp. 647-56, 1990
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