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|Antigen||Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) Antibodies|
|Epitope||AA 70-90, N-Term Alternatives|
|Reactivity||Rat (Rattus) Alternatives|
|Conjugate||This TRKB antibody is un-conjugated Alternatives|
Western Blotting (WB)
|2 references available|
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Product Details anti-TRKB AntibodyTarget Details TRKB Application Details Handling References for anti-TRKB antibody (ABIN3042870) Images
|Purpose||Rabbit IgG polyclonal antibody for BDNF/NT-3 growth factors receptor(NTRK2) detection. Tested with WB in Human,Mouse,Rat.|
|Sequence||EIFIANQKRL EIINEDDVEA Y|
Predicted Cross Reactivity: human, mouse,
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
Rabbit IgG polyclonal antibody for BDNF/NT-3 growth factors receptor(NTRK2) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: neurotrophic tyrosine kinase, receptor, type 2
Protein Name: BDNF/NT-3 growth factors receptor
|Purification||Immunogen affinity purified.|
|Immunogen||A synthetic peptide corresponding to a sequence at the N-terminus of human TrkB(70-90aa EIFIANQKRLEIINEDDVEAY), different from the related mouse and rat sequences by one amino acid.|
Target Details TRKBProduct Details anti-TRKB Antibody Application Details Handling References for anti-TRKB antibody (ABIN3042870) Images back to top
|Alternative Name||NTRK2 (NTRK2 Antibody Abstract)|
TrkB is also known as NTRK2. This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. Tropomyosin receptor kinase B is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations. The neurotrophins that activate TrkB are: BDNF (Brain Derived Neurotrophic Factor), neurotrophin-4 (NT-4), and neurotrophin-3 (NT-3). As such, TrkB mediates the multiple effects of these neurotrophic factors, which includes neuronal differentiation and survival.
Synonyms: AI848316 antibody|BDNF tropomyosine receptor kinase B antibody|BDNF/NT 3 growth factors receptor antibody|BDNF/NT-3 growth factors receptor antibody|Brain derived neurotrophic factor receptor antibody|C030027L06Rik antibody|EC 184.108.40.206 antibody|GP145 TrkB antibody|GP145-TrkB antibody|GP145-TrkB/GP95-TrkB antibody|GP95 TrkB antibody|Neurotrophic tyrosine kinase receptor type 2 antibody|Neurotrophin receptor tyrosine kinase type 2 antibody|NTRK 2 antibody|NTRK2 antibody|NTRK2_HUMAN antibody|Obesity, hyperphagia, and developmental delay, included antibody|RATTRKB1 antibody|Tkrb antibody|Trk B antibody|Trk-B antibody|TRKB antibody|TrkB tyrosine kinase antibody|TRKB1 antibody|Tropomyosin related kinase B antibody|tyrosine kinase receptor B antibody|Tyrosine receptor kinase B antibody
|Pathways||RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Skeletal Muscle Fiber Development, Feeding Behaviour, Dicarboxylic Acid Transport|
Application DetailsProduct Details anti-TRKB Antibody Target Details TRKB Handling References for anti-TRKB antibody (ABIN3042870) Images back to top
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Human, Mouse
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.
Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TRKB Antibody Target Details TRKB Application Details References for anti-TRKB antibody (ABIN3042870) Images back to top
|Reconstitution||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|Buffer||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.|
|Preservative||Thimerosal (Merthiolate), Sodium azide|
|Precaution of Use||This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
|Expiry Date||12 months|
References for anti-TRKB antibody (ABIN3042870)Product Details anti-TRKB Antibody Target Details TRKB Application Details Handling Images back to top
|Product cited in:||
Li, Li, Zhu, Wang, Liu, Li, Lu, Zhou: "The expression and putative role of brain-derived neurotrophic factor and its receptor in bovine sperm." in: Theriogenology, Vol. 77, Issue 3, pp. 636-43, 2012
Li, Gong, Wu, Lu, Shi: "Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by d-galactose in rats." in: Pharmacology, biochemistry, and behavior, Vol. 96, Issue 3, pp. 301-5, 2010
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