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|Antigen||Tuberous Sclerosis 1 (TSC1) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This TSC1 antibody is un-conjugated Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|1 reference available|
|Supplier||Log in to see|
Product Details anti-TSC1 AntibodyTarget Details TSC1 Application Details Handling References for anti-TSC1 antibody (ABIN711971) Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic phosphopeptide derived from human TSC1 around the phosphorylation site of Ser505 [FD(p-S)PF]|
Target Details TSC1Product Details anti-TSC1 Antibody Application Details Handling References for anti-TSC1 antibody (ABIN711971) Images back to top
|Alternative Name||Tsc1 (TSC1 Antibody Abstract)|
Hamartin, or TSC1, is a suspected tumor suppressor implicated in the disease tuberous sclerosis 1. It is a negative regulator of cell division controlling the transition from G0/G1 to S phase, and it seems to act through the phosphatidylinositol 3 kinase/Akt pathway. TSC1 interacts with tuberin m(TSC2), which is thought to be a GAP (GTPase Activating Protein) for the Rap1 and Rab5 small G Proteins. The Hamartin/Tuberin complex has been shown to inhibit mTor. Hamartin has also been shown to interact with ERM (Ezrin-Radixin-Moesin) proteins and with F-actin, suggesting a role for TSC proteins in modulation of cell adhesion and morphology.
Synonyms: TSC1phospho S505, LAM, TSC1, Tuberous sclerosis 1 protein.
|Pathways||RTK Signaling, AMPK Signaling, Regulation of Cell Size, Tube Formation|
Application DetailsProduct Details anti-TSC1 Antibody Target Details TSC1 Handling References for anti-TSC1 antibody (ABIN711971) Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-TSC1 Antibody Target Details TSC1 Application Details References for anti-TSC1 antibody (ABIN711971) Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
References for anti-TSC1 antibody (ABIN711971)Product Details anti-TSC1 Antibody Target Details TSC1 Application Details Handling Images back to top
|Product cited in:||
Cao, Wei, Liu, Wang, Wu, Xie, Capellini, Zhang, Zhao, Li, Zhong, Wang, Lu, Liu, Zhang, Du, Zhang, Du: "DNA methylation Landscape of body size variation in sheep." in: Scientific reports, Vol. 5, pp. 13950, 2016 Method employed by authors: Western Blotting (WB) (Sample species: Sheep (Ovine)).
ImagesProduct Details anti-TSC1 Antibody Target Details TSC1 Application Details Handling References for anti-TSC1 antibody (ABIN711971) back to top