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anti-Human TSC2 Antibodies:
anti-Mouse (Murine) TSC2 Antibodies:
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Human Polyclonal TSC2 Primary Antibody for DB, IF - ABIN1881949
Li, Inoki, Guan: Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. in Molecular and cellular biology 2004
Show all 6 Pubmed References
Human Polyclonal TSC2 Primary Antibody for WB - ABIN1881946
Dántola, Denofrio, Zurbano, Gimenez, Ogilby, Lorente, Thomas: Mechanism of photooxidation of folic acid sensitized by unconjugated pterins. in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2010
Show all 3 Pubmed References
Rat (Rattus) Polyclonal TSC2 Primary Antibody for DB - ABIN1881935
Larson, Liu, Stevens, Li, Li, Evers, Gao: Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1. in The Journal of biological chemistry 2010
Show all 3 Pubmed References
Human Polyclonal TSC2 Primary Antibody for DB - ABIN1881947
Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: A Large-scale genetic association study of esophageal adenocarcinoma risk. in Carcinogenesis 2010
Show all 3 Pubmed References
Human Monoclonal TSC2 Primary Antibody for ICC, IF - ABIN256563
Wang, Chen, Kuo, Su, Lai, Wang, Huang, Hoffman, Kuo, You, Chuang: Zebrafish Thsd7a is a neural protein required for angiogenic patterning during development. in Developmental dynamics : an official publication of the American Association of Anatomists 2011
Show all 2 Pubmed References
Human Polyclonal TSC2 Primary Antibody for IF (p), IHC (p) - ABIN701200
Wang, Chen, Deng, Bian, Huang, Lei, Lv, Liu, Li: Repression of TSC1/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast cell differentiation and proliferation. in International journal of biological macromolecules 2017
The gene expression profiles of WT and tsc2(+/-) larvae revealed 117 differentially expressed genes (DEGs), while between WT and tsc2(-/-) larvae and tsc2(+/-) and tsc2(-/-) larvae there were 1414 and 1079 DEGs, respectively. Pathway enrichment analysis from the WT and tsc2(-/-) DEGs, identified 14 enriched pathways from the up-regulated genes and 6 enriched pathways from the down-regulated genes.
This is the first report using an animal model to show interactions between tsc2, mTORC1 and p53 (show TP53 Antibodies) during tumorigenesis.
These results demonstrate a highly conserved role of tsc2 in zebrafish and establish a new animal model for studies of Tuberous sclerosis complex.
Rapamycin-independent IGF2 expression in Tsc2-null mouse embryo fibroblasts and human lymphangioleiomyomatosis cells.
This study demonstrated that the TSC2 mutation related the cerebellar abnormalities in tuberous sclerosis complex.
a novel TSC2 mutation is a cause of mild tuberous sclerosis in a family and has reduced expression
Data found that TSC2 negatively regulates the expression of EP3 (show PTGER3 Antibodies) in an mTORC1- independent manner.
All tuberous sclerosis patients were found to have mutations, which included 1 case with tuberous sclerosis 1 protein (TSC1 (show TSC1 Antibodies)) mutation and 9 cases with tuberous sclerosis 2 protein (TSC2) mutations (missense mutations in 6, nonsense mutations in 2, and frameshifting mutation in 1 case).
Results support important contributions of TSC2 heterozygous and homozygous mutant cells to the pathogenesis of TSC (show SLC12A3 Antibodies) and the important role of p53 (show TP53 Antibodies) during reprogramming.
Mutations in TSC2 gene on chromosome 9q34 that encode tuberin are associated with fetal Cardiac Rhabdomyoma that can be the initial finding in patients with Tuberous Sclerosis Complex. 5 known "pathogenic" TSC2-causing gene mutations were confirmed, also detected 6 "likely pathogenic" mutations.
When exposed to urotensin-II (show UTS2 Antibodies), TSC2-deficient cells exhibited greater migration, anchorage-independent cell growth, and matrix invasion
To the best of our knowledge, this is the first report of the c.3599G>C (p.R1200P) variant in exon 29 of the TSC2 gene related to a severe clinical course and multiple kidney transplants in a patient with tuberous sclerosis.
These results demonstrate Tsc2-deficient mesenchymal progenitors cause aberrant morphogenic signals, and identify an expression signature including Lgals3 (show LGALS3 Antibodies) relevant for human disease of TSC1 (show TSC1 Antibodies)/TSC2 inactivation and mTORC1 hyperactivity.
TSC (show SLC12A3 Antibodies) loss distorts DNA replication programme and sensitises murine embryonic fibroblasts to genotoxic stress.
Lymphangioleiomyomatosis is fatal lung disease associated with germline/somatic inactivating mutations in TSC2 genes. Data suggest lung lymphangioleiomyomatosis lesions and renal angiomyolipomas overexpress uPA (show PLAU Antibodies); Tsc2-/- (or Tsc1 (show TSC1 Antibodies)-/-) embryonic fibroblasts from knockout mice express higher uPA (show PLAU Antibodies) levels than wild-type cells. (uPA (show PLAU Antibodies) = urokinase-type plasminogen activator (show PLAU Antibodies); Tsc (show SLC12A3 Antibodies) = tuberous sclerosis complex protein)
Loss of the tuberous sclerosis complex (TSC (show SLC12A3 Antibodies)) tumor suppressors results in activation of mTORC1 and development of the tumor syndrome tuberous sclerosis complex (TSC (show SLC12A3 Antibodies)).
Tsc2-mTOR (show FRAP1 Antibodies) signaling in mesenchyme is essential for the maintenance of renal structure and for lung alveolarization.
TSC1 (show TSC1 Antibodies)/TSC2 complex upregulation of OPN (show SPP1 Antibodies) expression is mediated by transcription factor SOX9 (show SOX9 Antibodies) in an mTOR (show FRAP1 Antibodies)-independent manner. Moreover, ablation of OPN (show SPP1 Antibodies) by deficient TSC1 (show TSC1 Antibodies)/TSC2 complex contributed to inactivation of AKT (show AKT1 Antibodies) in TSC (show SLC12A3 Antibodies) cells
Rheb (show RHEB Antibodies) and TSC2 have roles in the mechanical activation of mTOR (show FRAP1 Antibodies) signaling
this study shows that TSC2 maintains macrophage quiescence and prevents mTORC1-dependent granulomatous disease with clinical implications for sarcoidosis
TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy/cell proliferation.
Repression of TSC1/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast cell differentiation and proliferation.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (show PRKAA1 Antibodies)/ERK (show MAPK1 Antibodies)/TSC2/mTOR (show FRAP1 Antibodies) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
prostaglandin F2alpha phosphorylates TSC2 and activates mTOR (show FRAP1 Antibodies) and ribosomal protein S6 (show RPS6 Antibodies) kinase (show RPS6KB1 Antibodies) signaling in an AKT (show AKT1 Antibodies)-independent manner
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.
tuberous sclerosis complex 2 (TSC2)
, tuberous sclerosis 2
, tuberous sclerosis 2 protein
, tuberous sclerosis 2 protein homolog
, renal carcinoma
, tuberous sclerosis 2 homolog protein