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anti-Human WASF1 Antibodies:
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Mammalian Monoclonal WASF1 Primary Antibody for ISt, IHC - ABIN1305050
Chazeau, Mehidi, Nair, Gautier, Leduc, Chamma, Kage, Kechkar, Thoumine, Rottner, Choquet, Gautreau, Sibarita, Giannone: Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion. in The EMBO journal 2014
Show all 6 Pubmed References
Human Polyclonal WASF1 Primary Antibody for ELISA, WB - ABIN548425
Suetsugu, Tanaka: Crystal growth of carbonate apatite using a CaCO3 flux. in Journal of materials science. Materials in medicine 2004
Show all 2 Pubmed References
Human Polyclonal WASF1 Primary Antibody for ELISA, WB - ABIN548460
Suetsugu, Miki, Takenawa: Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. in Biochemical and biophysical research communications 1999
Show all 3 Pubmed References
Human Polyclonal WASF1 Primary Antibody for ELISA, WB - ABIN548453
Leng, Zhang, Badour, Arpaia, Freeman, Cheung, Siu, Siminovitch: Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation. in Proceedings of the National Academy of Sciences of the United States of America 2005
Show all 2 Pubmed References
Cow (Bovine) Polyclonal WASF1 Primary Antibody for ELISA, WB - ABIN4365924
Beli, Mascheroni, Xu, Innocenti: WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2. in Nature cell biology 2008
Lpd regulates mesenchymal neural crest cell migration cell autonomously in Xenopus laevis via the Scar/WAVE complex.
this sudy identifies Wave1 as a maternal reprogramming factor that also has a necessary role in gene activation in development.
The rapid growth of roots in the light requires a functional ARP2/3-SCAR complex. Light is essential for stabilizing the SCAR complex in the plasma membrane, which is necessary for maintaining longitudinally organized F-actin to sustain rapid root growth.
Results from a study on gene expression variability markers in early-stage human embryos shows that WASF1 is a putative expression variability marker for the 3-day, 8-cell embryo stage.
WASP and SCAR drive pseudopod formation and are conserved in actin-filled pseudopod-based motility.
Results suggested that WAVE1 is a critical pro-autophagic protein capable of enhancing cell survival and regulating chemoresistance in leukemia cells potentially through the Beclin1/Bcl-2 and Beclin1/PI3K- complex-dependent pathways.
Results implicate a contributory role of WAVE1 and -3 to the metastatic phenotype of PC-3 cells through their interaction with the ARP2/3 complex.
we propose that WASF1 status defines a subtype of androgen deprivation therapy -resistant prostate cancer patients
a role for ARF6 in linking EGF-receptor signaling to Rac1 recruitment and activation at the plasma membrane to promote breast cancer cell directed migration
A decrease in amounts of WASF1 mRNA was also observed in human Alzheimer's disease brains, suggesting clinical relevance of the negative feedback circuit involved in homeostatic regulation of Abeta production
D620N mutation in VPS35 restricts WASH complex recruitment to endosomes, and reveals a novel role for the WASH complex in autophagosome formation.
WAVE1 has unique activities independent of Arp2/3 complex that can govern both the growth rates and architectures of actin filament networks. Elongation inhibitory effects of WAVE1 were mapped to its WH2 ("V") domain.
The WAVE complex is the main activator of the Arp2/3 complex for actin filament nucleation and assembly in the lamellipodia of moving cells.
WAVE1 might promote the proliferative and invasive malignant behaviors through the activation of the PI3K/AKT and p38MAPK signaling pathways in epithelial ovarian cancer.
Scar/WAVE regulatory complex and N-WASP play opposing roles in 3D epithelial cell migration
mRNAs encoding structural and regulatory components of the WAVE complex are localized to the leading edge of the cell, suggesting that localized protein synthesis plays a pivotal role in controlling cell spreading and migration.
Study finds that WAVE1 overexpression is associated with an unfavorable prognosis. WAVE1 is an independent prognostic factor for EOC, which suggests that it is a novel and crucial predictor for EOC metastasis.
mDia1 and WAVE2 are important Src homology 3 domain partners of IRSp53 in forming filopodia.
Arf GTPases may be central components in WAVE signalling, acting directly, alongside Rac1.
WAVE1 might be involved in the migration and invasion of K562 cells through regulation of the expression level of MMP-2.
Higher levels of WAVE1 in the bone marrow indicate an unfavorable prognosis in children with AML.
Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex
CIP4 is a new ArgBP2 interacting protein that modulates the ArgBP2 mediated control of WAVE1 phosphorylation and cancer cell migration.
Wiskott-Aldrich syndrome protein family (WAVE1) knocked out (KO) in neurons expressing the D1 dopamine receptor (D1-KO) exhibited a significant decrease in place preference associated with cocaine.
We identified a phosphorylation-dependent mechanism that regulates selective recruitment of these effectors to Lamellipodin: Abl-mediated Lamellipodin phosphorylation promotes its association with both Scar/WAVE and Ena/VASP, whereas Src-dependent phosphorylation enhances binding to Scar/WAVE but not to Ena/VASP
WAVE1 phosphorylation in podocytes. Synaptopodin is a well-characterized target of CsA. WAVE1 overexpression and synaptopodin knockdown experiments directly demonstrated that WAVE1 expression is not dependent on synaptopodin expression, and vice versa
Signaling through WAVE-1 plays a critical role in establishing normal synaptic architecture in the rodent hippocampus.
Lpd directly binds active Rac, which regulates a direct interaction between Lpd and the Scar/WAVE complex
An unanticipated role for WAVE1 as a critical modulator of the innate immune response to severe bacterial infections.
role in causing sensorimotor retardation and reduced learning and memory in mice
In cell migration WAVE1 is essential in MMP-dependent migration in extracellular matrix and WAVE2 is for leading edge extension for directed migration in general.
Nap1 mutant phenotypes define the crucial roles of Nap1/WAVE-mediated actin regulation in tissue organization and establishment of the body plan of the mammalian embryo.
data suggest that phosphorylation/dephosphorylation of WAVE1 in neurons has an important role in the formation of the filamentous actin cytoskeleton, and thus in the regulation of dendritic spine morphology
NESH (Abi-3), like Abi-1 and Abi-2, is a component of the Abi/WAVE complex, but likely plays a different role in the regulation of c-Abl.
WAVE-1 signaling complexes control aspects of neuronal morphogenesis and synaptic plasticity.
Major role for Scar/WAVE-1 in mediating platelet cytoskeletal reorganization and aggregate formation downstream of activation by GPVI.
WAVE accumulation may be involved in Abeta/amyloid precursor protein mediated-tangle modification
Data show that WAVE1 sequestration to the nucleus is required during fertilization, and is an actin-independent event that relies on dynamic microtubules but not nuclear pores.
The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
WASP family protein member 1
, homology of dictyostelium scar 1
, protein WAVE-1
, verprolin homology domain-containing protein 1
, wiskott-Aldrich syndrome protein family member 1
, WASP family 1