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|Antigen||Cholinergic Receptor, Nicotinic, alpha 10 (CHRNA10) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||Alexa Fluor 350 Alternatives|
Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
|Supplier||Log in to see|
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|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human CHRNA10|
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|Alternative Name||Chrna10 (CHRNA10 Antibody Abstract)|
Members of the ligand-gated ion channel receptor family are characterized by their fast transmitting response to neurotransmitters. Two important members of this family are the nicotinic acetylcholine and glutamate receptors, both of which are composed of five homologous subunits forming a transmembrane aqueous pore. These transmembrane receptors change conformation in response to their cognate neurotransmitter. Nicotinic acetylcholine receptors (AChRs) are found at the postsynaptic membrane of the neuromuscular junction and bind acetylcholine molecules, allowing ions to move through the pore. Glutamate receptors are found in the postsynaptic membrane of cells in the central nervous system. The activity that is generated at the synapse by the binding of acetylcholine is terminated by acetylcholinesterase, an enzyme that rapidly hydrolyzes acetylcholine. ACh Ralpha 10, also known as CHRNA10, is a 450 amino acid multi-pass membrane protein expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes. AChR alpha 10 forms a hetero-oligomeric channels in conjunction with AChR alpha 9 and is considered an ionotropic receptor with a probable role in the modulation of auditory stimuli.
Subcellular location: Extracellular
Synonyms: Acetylcholine receptor, neuronal nicotinic, alpha-10 subunit, ACH10_HUMAN, Alpha 10 nAChR, Cholinergic receptor nicotinic alpha 10, Cholinergic receptor, neuronal nicotinic, alpha polypeptide 10, Cholinergic receptor, nicotinic, alpha polypeptide 10, CHRNA 10, CHRNA10, NACHR alpha 10, NACHR alpha-10, NACHRA10, Neuronal acetylcholine receptor protein subunit alpha 10, Neuronal acetylcholine receptor subunit alpha-10, Nicotinic acetylcholine receptor subunit alpha 10, Nicotinic acetylcholine receptor subunit alpha-10.
|Pathways||Sensory Perception of Sound, Synaptic Membrane|
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|Application Notes||FCM(1:20-100), IF(IHC-P)(1:50-200)|
|Restrictions||For Research Use only|
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|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at 4°C|
|Expiry Date||12 months|