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In the hippocampus of developing piglet brain the alpha-1 and beta-2 subunits were shown to immunolabel various cells and processes in the dentate gyrus (DG), CA1 (show CA1 Proteins) and CA3 (show CA3 Proteins).
Results provide plausible epigenetic evidence of the GABAA (show GABRg1 Proteins) receptor beta2 subunit involvement in the schizophrenia-like behaviors and demonstrate the potential use of zebrafish models in neuropsychiatric research.
we report the discovery of a de novo heterozygous missense mutation in the GABRB2 gene that encodes the b2 subunit of the GABAA (show GABRg1 Proteins) receptor. Our in vitro studies indicate that this mutation causes Early myoclonic encephalopathy via disruption of GABAergic inhibition in the brain
The GABRB2 downregulation significantly inhibited the colony formation, migration, and invasion of the three PTC (show F9 Proteins) cell lines and GABRB2 plays important tumorigenic functions and acts as a novel oncogene (show RAB1A Proteins) in papillary thyroid carcinoma.
These results reveal alterations in GABRB2 genotype-dependent methylation and hydroxymethylation in schizophrenia.
Data show evidence for the schizophrenia candidate gene gamma-aminobutyric acid A receptor beta 2 (GABRB2) to play a role in heroin dependence.
Our findings underscore the need for further investigation into the mechanisms by which mutations in GABRB2 contribute to neurological and developmental dysfunction.
Deletion of the N-terminal extension and putative alpha-helix in heteromeric alpha1beta2gamma2 GABAA (show GABRg1 Proteins) receptors in the beta2 subunit affected GABA sensitivity and desensitization.
Both mRNA and protein of GABAB receptor subunits, GABAB1 (show GABBR1 Proteins) and GABAB2, were co-expressed in cultured human RPE (show RPE Proteins) cells; GABAB receptors regulate the [Ca2 (show CA2 Proteins)+]i via a pertussis toxin-sensitive Gi/o-protein pathway and a phospholipase C (show PLC Proteins) pathway
This study demonstrates altered patterns of N-glycosylation of GABRB2 in the temporal lobe in schizophrenia.
high expression of GABBR2 (show GABBR2 Proteins) with a low expression of GABR(A3) may predict a better outcome in non-small cell lung cancer
These findings revealed that GABRB2 is associated with psychosis, the core symptom and an endophenotype of schizophrenia.
Rebound potentiation is an input-specific plasticity that occurs only at basket cell-Purkinje cell inhibitory synapses and critically relies on GABAA (show GABRg1 Proteins) receptors containing the beta2-subunit.
Gabrb2 receptor subunits are expressed in interneurons of the dentate gyrus along with alpha1 and delta subunits.
In an epileptic stargazer mouse model, Gabrb2 receptor subunit expression in the ventral thalamus is increased.
These studies identify a novel gephyrin (show GPHN Proteins)-binding motif in GABA(A) R beta2 and beta3 large cytoplasmic loops.
Data indicate that the expression levels of [beta]2/3 GABAAR (show GABRG2 Proteins) showed 2.81 +/- 0.08-fold and 3.83 +/- 0.07-fold increases, respectively, in the pancreatectomized mice 3 and 14 days after surgery.
Differential cell surface expression of GABAA (show GABRg1 Proteins) receptor alpha1, alpha6, beta2 and beta3 subunits in cultured mouse cerebellar granule cells influence of cAMP-activated signalling.
deletion of beta2 subunit of GABAA (show GABRg1 Proteins) receptors reduces actions of alcohol and other drugs
a conserved lysine in the TM2 (show TPM1 Proteins)-3 of alpha1, beta2, and gamma2 of the GABA-A receptor has an asymmetric function in different GABAA (show GABRg1 Proteins) subunits
Results describe an up-regulation in the tyrosine kinase (show TYRO3 Proteins) phosphorylation of GABA(A )receptor beta(2)- and gamma(2)-subunits following chronic ethanol exposure, but no effect on alpha(1)-subunit in mouse cultured cortical neurons.
Different NMDA-receptor subunit 1 and GABA(B)-receptor subunit 2 (show PSMB6 Proteins) levels observed in naive mouse strains reflect strain-dependent expression of subunits and are proposed to lead to altered stoichiometry of GABA(B)-receptor complexes.
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion.
gamma-aminobutyric acid (GABA) A receptor, beta 2
, GABA A receptor beta 2 subunit
, gamma-aminobutyric acid receptor subunit beta-2
, gamma-aminobutyric acid receptor subunit beta-2-like
, GABA(A) receptor subunit beta-2
, Gamma-aminobutyric acid receptor beta 2
, gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2
, gamma-aminobutyric acid receptor, subunit beta 2
, GABAA receptor betaZ2
, gamma-aminobutyric acid A receptor, beta 2
, GABA-A receptor, beta-2 subunit
, gamma-aminobutyric acidA receptor beta 2 subunit
, GABA(A) receptor, beta 2
, gamma-aminobutyric acid A receptor beta 2
, gamma-aminobutyric acid A receptor, subunit beta 2
, gamma-aminobutyric acid receptor beta-2 subunit