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our analyses uncover essential roles of Six1 in hair cell differentiation and formation of the organ of Corti in the mammalian cochlea
SIX1 regulates dorsal arch development not only by inducing dorsal Jag1 (show JAG1 ELISA Kits) expression but also by inhibiting endothelin 1 (Edn1 (show EDN1 ELISA Kits)) expression in the pharyngeal endoderm of the dorsal arch, thus preventing dorsal EDNRA (show EDNRA ELISA Kits) signaling.
significant co-localization of binding sites for MyoD (show MYOD1 ELISA Kits) and Six proteins on over a thousand mouse genomic DNA regions, were found.
we show that SIX1 binds to adipogenic and brown marker genes and interacts with C/EBPa (show CEBPA ELISA Kits), C/EBPb (show CEBPB ELISA Kits) and EBF2 (show EBF2 ELISA Kits), suggesting their functional cooperation during adipogenesis.
Studies strongly suggest that Six1 overexpression promotes CRC (show SCRIB ELISA Kits) growth and metastasis and remodels tumor stroma by stimulating angiogenesis and recruiting TAM (show CCNA1 ELISA Kits). MAPK (show MAPK1 ELISA Kits) activation may be a pivotal event in Six1-associated tumor progression.
Downregulation of Six1 effectively inhibited airway inflammation and reversed airway remodeling, which suggest that Six1 represents a promising therapeutic strategy for human allergic asthma.
results suggest that SIX1 is a key proliferation regulator in mouse DFCs and human PDLCs, which provides novel insight into Six family gene function in mammals.
Our findings imply that SIX1 may play a role as an important regulator to orchestrate the dynamic of uterine endometrium in response to estrogen level during the estrous cycle.
Activation of Six1 Expression in Vertebrate Sensory Neurons.
Six1 knockdown caused a fast-to-slow shift in myosin heavy chain isoform
in non-small cell lung cancer, SIX1-5 were associated with the greater possibility of the tumorigenesis
SIX1 oncoprotein is aberrantly expressed in the endometrium following developmental exposure to estrogenic chemicals, correlates with uterine cancer, and is a biomarker in human endometrial cancers
SIX homeobox 1 (SIX1) regulates cellular senescence by a p16INK4A (p16)-dependent mechanism.
PTH2R (show PTH2R ELISA Kits) and its ligand TIP39 (show TFIP11 ELISA Kits) regulate intracellular calcium and influence keratinocyte differentiation
Studies strongly suggest that Six1 overexpression promotes CRC (show CALR ELISA Kits) growth and metastasis and remodels tumor stroma by stimulating angiogenesis and recruiting TAM (show CCNA1 ELISA Kits). MAPK (show MAPK1 ELISA Kits) activation may be a pivotal event in Six1-associated tumor progression.
Restoration of SIX1 was sufficient to abolish proliferation, migration and invasion induced by miR (show MLXIP ELISA Kits)-362 overexpression in cervical cancer cells. The newly identified miR (show MLXIP ELISA Kits)-362/SIX1 pathway provides insight into cervical cancer progression, and may represent a novel therapeutic target.
study replicated the association of POAG with two SNPs at the SIX1-SIX6 (show SIX6 ELISA Kits) locus and demonstrated that SNPs, rs10483727 and rs33912345, are significantly associated with POAG, especially with NTG (show OPA1 ELISA Kits) in patients aged above 40 years
miR (show MLXIP ELISA Kits)-188 suppresses proliferation and invasion by targeting SIX1 in oral squamous cell carcinoma cells.
Pro-survival effects by NF-kappaB (show NFKB1 ELISA Kits), Akt (show AKT1 ELISA Kits) and ERK(1 (show MAPK3 ELISA Kits)/2) and anti-apoptosis actions by Six1 disrupt apoptotic functions of TRAIL-Dr4/5 pathway in ovarian cancer, which may explain why up-regulated DR4 and DR5 (show TNFRSF10B ELISA Kits) in ovarian cancer are associated with poor prognosis and low survival ratio of the patients.
The HD domain is important for the nuclear localization of porcine Six1 protein.
Six1 and Eya1 (show EYA1 ELISA Kits) can both promote and arrest neuronal differentiation by activating the Notch (show NOTCH1 ELISA Kits) pathway genes.
these findings establish an interaction between Pa2G4 (show PA2G4 ELISA Kits) and Six1, and demonstrate that it has an important role in the development of tissues affected in Branchiootorenal Spectrum disorder.
Microarray identification of novel genes downstream of Six1, a critical factor in cranial placode, somite, and kidney development.
The results indicated the critical role of Six1 in transition of Rohon-Beard cells to dorsal root ganglia (DRG) neurons during Xenopus development and establishment of exclusive DRG system of mice.
Eya1 (show EYA1 ELISA Kits) and Six1 are required for both the regulation of placodal neuronal progenitor proliferation, through their effects on SoxB1 expression, and subsequent neuronal differentiation.
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3).
homeobox protein SIX1
, sine oculis homeobox homolog 1
, sine oculis-related homeobox 1 homolog
, Sine oculis homeobox homolog 1
, homeobox protein six1