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Browse our SRRM4 Proteins (SRRM4)

Full name:: Serine/arginine Repetitive Matrix 4 Proteins (SRRM4)

On www.antibodies-online.com are 2 Serine/arginine Repetitive Matrix 4 (SRRM4) Proteins from 1 different suppliers available. Additionally we are shipping SRRM4 Antibodies (4) and many more products for this protein. A total of 8 SRRM4 products are currently listed.

Synonyms:: 1500001A10Rik, B230202K19Rik, im:7136231, KIAA1853, mKIAA1853, MU-MB-2.76, nSR100, RGD1560213, si:dkey-1k23.1, SRRM2C, ZnSR100

list all proteins	Gene Name	GeneID	UniProt
	SRRM4	84530	A7MD48
	SRRM4	68955	Q8BKA3
Rat SRRM4	SRRM4	498189
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SRRM4 Proteins (SRRM4) by Origin

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Relevant Pathways for SRRM4 Proteins

Sensory Perception of Sound

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Human Serine/arginine Repetitive Matrix 4 (SRRM4) interaction partners

SRRM4 expression in castrate-resistant pancreatic cancer is highly correlated with neuroendocrine prostate cancer and poor survival.
a novel mechanism by which SRRM4 drives neuroendocrine prostate cancer progression via a pluripotency gene network, is reported.
data indicate that SRRM4 regulates alternative RNA splicing of the Bif-1 gene that enables PCa cells resistant to apoptotic stimuli under anti-cancer therapies, and may contribute to AdPC progression into t-NEPC.
SRRM4 regulates alternative splicing programs to drive neuroendocrine prostate cancer progression (an aggressive subtype of castration-resistant prostate cancer) under androgen receptor pathway inhibition.
Neuronal activity-dependent microexons are nSR100 targets and are misregulated in autism.
The splicing of REST by SRRM4 could promote the neuroendocrine phenotype in CRPC.
Neural microexons are regulated by the neuronal-specific splicing factor nSR100/SRRM4, through its binding to adjacent intronic enhancer motifs; neural microexons are frequently misregulated in the brains of individuals with autism spectrum disorder, and this misregulation is associated with reduced levels of nSR100.
findings show that nSR100 plays a role in the alternative splicing of REST in small cell lung cancer (SCLC); study provides new insight into the role of nSR100 in the expression of sREST, possibly in the pathogenesis of SCLC

Mouse (Murine) Serine/arginine Repetitive Matrix 4 (SRRM4) interaction partners

Results suggest that SRRM4 controls neurite outgrowth through regulation of alternative splicing of protrudin transcripts.
Neuronal activity-dependent microexons are nSR100 targets and are misregulated in autism.
Loss of nSR100 impairs development of the central and peripheral nervous systems in part by disrupting neurite outgrowth, cortical layering in the forebrain, and axon guidance in the corpus callosum
findings show that nSR100 plays a role in the alternative splicing of REST in small cell lung cancer (SCLC); study provides new insight into the role of nSR100 in the expression of sREST, possibly in the pathogenesis of SCLC
required for the continued survival and differentiation of inner and vestibular hair cells past a set point in their development
Srrm4 function is critical in the hearing and balance organs, but not in all neural tissues. Srrm4 is the first alternative-splicing regulator to be associated with hearing. Analysis of bv mice provides exon-level insights into hair-cell development.
role for nSR100 in the inhibition of REST activity, blocking nSR100 expression in the developing mouse brain impairs neurogenesis
Study identified the neural-specific SR-related protein of 100 kDa (nSR100)& shows that nSR100 regulates an extensive network of brain-specific alternative exons enriched in genes that function in neural cell differentiation.

SRRM4 Protein Profile

Protein Summary

SRRM4 promotes alternative splicing and inclusion of neural-specific exons in target mRNAs (Calarco et al., 2009

Alternative names and synonyms associated with SRRM4

serine/arginine repetitive matrix 4 (SRRM4)
serine/arginine repetitive matrix 4 (Srrm4)
serine/arginine repetitive matrix 4 (srrm4)

1500001A10Rik protein
B230202K19Rik protein
im:7136231 protein
KIAA1853 protein
mKIAA1853 protein
MU-MB-2.76 protein
nSR100 protein
RGD1560213 protein
si:dkey-1k23.1 protein
SRRM2C protein
ZnSR100 protein

Protein level used designations for SRRM4

medulloblastoma antigen MU-MB-2.76 , neural-specific SR-related protein of 100 kDa , neural-specific serine/arginine repetitive splicing factor of 100 kDa , serine/arginine repetitive matrix protein 4 , KIAA1853 protein-like , serine/arginine repetitive matrix 2C , serine/arginine repetitive matrix 4 , Neural-specific serine/arginine repetitive splicing factor of 100 kDa

GENE ID	SPECIES
84530	Homo sapiens
416989	Gallus gallus
611405	Canis lupus familiaris
614115	Bos taurus
68955	Mus musculus
498189	Rattus norvegicus
796574	Danio rerio

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