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Human DOCK1 ELISA Kit for Sandwich ELISA - ABIN813713
Pan, Li, Duan, Yuan, Fan, Fan, Xiaokaiti, Yang, Wang, Li: Enoxaparin Sensitizes Human Non-Small-Cell Lung Carcinomas to Gefitinib by Inhibiting DOCK1 Expression, Vimentin Phosphorylation, and Akt Activation. in Molecular pharmacology 2015
A novel signaling cascade is identified in which ELMO1 (show ELMO1 ELISA Kits)/DOCK180 regulates vasculature formation in zebrafish.
The fusion of embryonic fast-twitch myoblasts requires the activities of Dock1 and the closely related Dock5 protein.
Data suggest that GPR124 (show GPR124 ELISA Kits) promotes cell adhesion via interaction with Elmo1 (show ELMO1 ELISA Kits)-Dock180 and intersectin 1 (show ITSN1 ELISA Kits)/2; this constitutes a previously unrecognized heteromeric complex that is putatively involved in GPR124 (show GPR124 ELISA Kits)-dependent adhesive/angiogenic responses in vascular endothelial cells. (GPR124 (show GPR124 ELISA Kits) = G-protein coupled receptor 124 (show GPR124 ELISA Kits); Elmo1 (show ELMO1 ELISA Kits) = ELMO domain-containing protein 1 (show ELMOD1 ELISA Kits); Dock180 = dedicator of cytokinesis protein 1 180 kDa)
stimulation of the DOCK180 pathway represents an alternative mechanism of PTP1B (show PTPN1 ELISA Kits) inhibitor-stimulated endothelial cell motility, which does not require concomitant VEGFR2 (show KDR ELISA Kits) activation as a prerequisite.
Thus, Elmo1 (show ELMO1 ELISA Kits) and Dock180 facilitate blood vessel formation by stabilization of the endothelium during angiogenesis.
High DOCK180 expression is associated with serous ovarian cancer.
our findings describe a novel mechanism by which EGFRvIII drives glioma tumorigenesis and invasion through protein kinase A-dependent phosphorylation of Dock180
findings indicate that a chemokine-controlled pathway, consisting of Galphai2, ELMO1/Dock180, Rac1 and Rac2, regulates the actin cytoskeleton during breast cancer metastasis
Dock180 could act as a pro-survival molecule in H9C2 cardiomyocytes via activation of its downstream pro-survival signaling molecule, AKT (show AKT1 ELISA Kits).
Solved is the solution structure of DOCK180 SH3 domain (show ITSN1 ELISA Kits), which shares similar target binding features with the SH3 domain (show ITSN1 ELISA Kits) of DOCK2 (show DOCK2 ELISA Kits).
DOCK1-Rac (show AKT1 ELISA Kits) signaling as an HER2 (show ERBB2 ELISA Kits) effector pathway essential for HER2 (show ERBB2 ELISA Kits)-mediated breast cancer progression to metastasis.
Phosphorylation of Dock180(Y1811) enhanced its association with CrkII (show CRK ELISA Kits) & p130(Cas (show BCAR1 ELISA Kits)). Dock180 associated with PDGFRalpha to promote cell migration. Phosphorylated Dock180(Y1811) contributes to activation of Rac1 in human cancers with PDGFRA (show PDGFRA ELISA Kits) amplification.
Inactivation of Dock1 in mammary gland epithelial cells and activation of Stat3 (show STAT3 ELISA Kits) coincide with a delay in the initiation of mammary gland involution.
Dock1 and Dock5 are not the important exchange factors regulating Rac (show AKT1 ELISA Kits) activity during the establishment and maintenance of the glomerular barrier
The phospholipase D (show PLD ELISA Kits)-PA axis selectively controls dorsal ruffle formation by regulating DOCK1 localization.
The data demonstrate the ability of the SH3 domain (show ITSN1 ELISA Kits) of DOCK180 to interact with ELMO1 (show ELMO1 ELISA Kits), regardless of the presence of the polyproline-containing C-terminal end.
Dock1 has an essential role in embryonic development.
Results indicate that the combination of DOCK2 (show DOCK2 ELISA Kits) and DOCK180 plays a significant but not essential role in prevascular fetal thymus colonization.
This gene product binds to the SH3 domain of CRK protein. It may regulate cell surface extension and may have a role in the cell surface extension of an engulfing cell around a dying cell during apoptosis.
dedicator of cytokinesis protein 1
, dedicator of cytokinesis 1
, dedicator of cytokinesis protein 1-like
, dedicator of cytokinesis protein 11
, dedicator of cytokinesis 11
, Dedicator of cytokinesis protein 11
, dedicator of cytokinesis protein 11-like
, 180 kDa protein downstream of CRK
, DOwnstream of CrK
, dedicator of cyto-kinesis 1