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Lmna (show LMNA Antibodies) gene product might play a crucial role in the ChAT-dependent molecular differentiation cascade.
cholinergic transmission in the knock-out dorsal motor nucleus of vagus was overactivated because knock-out mice lack CPEB2-suppressed translation of the rate-limiting enzyme in the production of acetylcholine (i.e., choline acetyltransferase)
Study describes in detail a population of choline acetyltransferase immunoreactive /glutamate decarboxylase 67 (show GAD1 Antibodies) neurons predominantly ventral to the central canal of the cervical, thoracic and lumbar spinal cord of adult and juvenile mice. These cells potentially correspond to a sub-population of the cholinergic central canal cluster cells which may play a unique role in controlling spinal cord circuitry.
The isolation and characterization of CD4 (show CD4 Antibodies) TChAT cells will enable analysis of the role of these cells in hypotension and hypertension, and may suggest novel therapeutic strategies by targeting cell-mediated vasorelaxation.
Microgravity causes substantial down-regulation of nerve tissue proteins, choline acetyltransferase, NF200 (show NEFH Antibodies), and calbindin (show CALB1 Antibodies) in mouse motor neurons.
These studies indicate a novel relationship between cholinergic neurons and APP (show APP Antibodies) processing, with 82-kDa ChAT acting as a negative regulator of Abeta (show APP Antibodies) production
increased REST/NRSF expression and its effect on the regulatory region for choline acetyltransferase (ChAT) transcription could explain the decreased expression of ChAT in the Alzheimer's disease transgenic mouse
chronic social defeat stress in mice produces stress-related behaviors; a decrease in the Chat level at days 12 and 27 was noted in the prefrontal cortex (PFC (show CFP Antibodies)), amygdala (Amyg), and dorsal hippocampus (HIP) in defeated mice
In choline acetyltransferase transgenic mice the activated cardiac ACh (show FGFR3 Antibodies)-HIF-1alpha (show HIF1A Antibodies) cascade improves survival after myocardial infarction.
After bilateral common carotid artery occlusion, peripherin (show PRPH Antibodies) overexpression was significantly correlated with reduction in ChAT activity
We have identified a zebrafish mutant line, bajan, in which compromised motility and fatigue result from a point mutation in the gene coding choline acetyltransferase
Compared with the control group, the densitometric quantification and mean density of GPR43 (show FFAR2 Antibodies) and ChAT proteins, and expression of GPR43 (show FFAR2 Antibodies) and CHAT genes, were significantly decreased in the patients with mixed refractory constipation.
Results suggest that SATB1 (show SATB1 Antibodies) is activated to bind to chromatin at S/MARs (show MARS Antibodies) after exposure to Abeta (show APP Antibodies) 1-42, resulting in alternative utilization and movement of 82-kDa ChAT to these regions demonstrating that both proteins play critical roles in the response of neural cells to acute Abeta (show APP Antibodies)-exposure.
We conducted a meta-analysis of studies involving CHAT, TFAM (show TFAM Antibodies), and VR22 (show CTNNA3 Antibodies) polymorphisms and Alzheimer disease susceptibility.For CHAT, rs2177369 (G>A) in whites and rs3810950 (G>A) in Asians were found to be associated with AD susceptibility. No association was detected between rs1880676 and rs868750 and AD risk.
There is a striking variability in the severity of phenotypes resulting from mutations in CHAT, which is the only gene so far known to be linked with congenital deficiency of ACh (show FGFR3 Antibodies) synthesis.
Data show thata the expression of choline acetyltransferase (ChAT) is reduced in the postmortem alcoholic basal forebrain in comparison to moderate drinking controls.
There was a loss of choline O-acetyltransferase in the visual cortex of dementia with Lewy bodies patients.
the functional consequences of 12 missense and one nonsense mutations of CHAT in 11 patients. ( choline acetyltransferase)
The results revealed broad coexistence of ChAT and CGRP (show CALCA Antibodies) in the spinal cord neurons which implies that the neurons synthesize and store ChAT and CGRP (show CALCA Antibodies) in their cell bodies.
This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform.
, choline O-acetyltransferase
, choline acetylase
, acetyl CoA:choline O-acetyltransferase