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Human Polyclonal NOV Primary Antibody for IHC (p), ELISA - ABIN2474328
Mück, Henion: High-performance liquid chromatography/tandem mass spectrometry: its use for the identification of stanozolol and its major metabolites in human and equine urine. in Biomedical & environmental mass spectrometry 1990
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Taken together, our results suggest that palmitoylation by ZDHHC22 at C241 in the CCN3 TSP1 (show THBS1 Antibodies) domain may be required for the secretion of CCN3. Aberrant palmitoylation induces intracellular accumulation of CCN3, inhibiting neuronal axon growth.
CCN3 (Nov) and CCN5 (WISP2 (show WISP2 Antibodies)) are novel substrates of MMP14 (show MMP14 Antibodies).
Reduced levels of CCN1 (show CCNA2 Antibodies) and CCN3, as found in early-onset preeclampsia, could contribute to a shift from invasive to proliferative extravillous trophoblasts and may explain their shallow invasion properties in this disease.
our findings establish CCN3 as a pivotal regulator of androgen receptor (AR (show AR Antibodies)) signaling and prostate cancer progression and suggest a functional intersection between EZH2 (show EZH2 Antibodies) and AR signaling in castration-resistant prostate cancer
The present study aimed to examine the clinical relevance of NOV along with CYR61 (show CYR61 Antibodies) and CTGF (show CTGF Antibodies) in gastric cancer by analysing their transcript levels...the expression of NOV and CYR61 (show CYR61 Antibodies) was increased in gastric cancer. The elevated expression of CYR61 (show CYR61 Antibodies) was associated with poorer survival. NOV promoted proliferation and invasion of gastric cancer cells
Studies indicate that the CYR61 (show CYR61 Antibodies) CTGF (show CTGF Antibodies) NOV matricellular proteins (CCN family of proteins) comprises the members CCN1 (show CCNA2 Antibodies), CCN2 (show CTGF Antibodies), CCN3, CCN4 (show WISP1 Antibodies), CCN5 (show WISP2 Antibodies) and CCN6 (show WISP3 Antibodies) and have been identified in various types of cancer.
NOV expression was highly increased in biopsies of patients with tubulointerstitial nephritis.
Results revealed that NOV regulates the tumor growth of osteosarcoma cells through activation of the MAPK (show MAPK1 Antibodies) signaling pathway and promotes osteosarcoma cell migration in vitro.
our results argue that MZF-1 (show ZFP42 Antibodies) regulates the CTGF (show CTGF Antibodies) and NOV genes in the hematopoietic compartment, and may be involved in their respective functions in the stroma.
Overexpression of CCN3 induces M2 macrophage infiltration and contributes to angiogenesis in prostate cancer microenvironment.
Taken together, our results suggest that palmitoylation by ZDHHC22 at C241 in the CCN3 TSP1 (show GZMA Antibodies) domain may be required for the secretion of CCN3. Aberrant palmitoylation induces intracellular accumulation of CCN3, inhibiting neuronal axon growth.
Administration of EET alters Wnt1 (show WNT1 Antibodies), NOV, and HO-1 (show HMOX1 Antibodies) signaling to prevent obesity-induced cardiomyopathy in obese mice.
PLXNA1 (show PLXNA1 Antibodies) mediates the acquisition of malignant phenotypes induced by autocrine SEMA3A (show SEMA3A Antibodies) signaling in lung cancer cells.
results show that NOV is a new adipocytokine that could be involved in obesity-associated insulin (show INS Antibodies)-resistance.
Study showed that progenitor cells lining the telencephalic ventricles express PlexinA1 (show PLXNA1 Antibodies) and that absence of this receptor impairs neurogenesis in the developing forebrain
Genetic and pharmacological approaches implicated the ERK1/2 pathway as a critical regulator of CCN3-dependent AAA (show AAAS Antibodies) development.
Reduced NOV expression limits inflammation and interstitial renal fibrosis after obstructive nephropathy in mice.
NOV is required for the maintenance of articular cartilage and for joint homeostasis, with disruption of NOV in ageing Nov(del3)-/- male mice causing osteoarthritis-like disease.
tight regulation of CCN3 expression is necessary for normal cortical neuronal connectivity during development, and RAB25 (show RAB25 Antibodies) negatively regulates neuronal differentiation as a downstream effector of CCN3
CCN3 overexpression is associated with control of inflammatory processes and reversion of dyslipidemia in the process of atherosclerosis, which implies that CCN3 may be a promising target in the treatment of atherosclerosis.
The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development.
CCN family member 3
, IGF-binding protein 9
, insulin-like growth factor-binding protein 9
, nephroblastoma-overexpressed gene protein homolog
, protein NOV homolog
, nephroblastoma overexpressed gene protein homolog
, nephroblastoma overexpressed gene protein
, nephroblastoma-overexpressed gene protein
, protein NOV
, plex 1
, plexin 1