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anti-Human RAB5 Antibodies:
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Human Polyclonal RAB5 Primary Antibody for ICC, IF - ABIN266020
Sönnichsen, De Renzis, Nielsen, Rietdorf, Zerial: Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11. in The Journal of cell biology 2000
Show all 8 Pubmed References
Human Monoclonal RAB5 Primary Antibody for IF, IP - ABIN967882
Huang, Imamura, Olefsky: Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein. in Proceedings of the National Academy of Sciences of the United States of America 2001
Show all 5 Pubmed References
Human Monoclonal RAB5 Primary Antibody for IF, IP - ABIN967881
Li, Stahl: Structure-function relationship of the small GTPase rab5. in The Journal of biological chemistry 1993
Show all 5 Pubmed References
Dog (Canine) Monoclonal RAB5 Primary Antibody for IF, IHC - ABIN968139
Sanford, Pan, Wessling-Resnick: Prenylation of Rab5 is dependent on guanine nucleotide binding. in The Journal of biological chemistry 1993
Show all 4 Pubmed References
Dog (Canine) Monoclonal RAB5 Primary Antibody for IF, IHC - ABIN968138
Stenmark, Vitale, Ullrich, Zerial: Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion. in Cell 1996
Show all 4 Pubmed References
Human Monoclonal RAB5 Primary Antibody for ELISA, WB - ABIN519585
Chamberlain, Oberg, Furber, Poland, Hawrysh, Knafelc, McBride, Anderson: Deregulation of Rab5 and Rab4 proteins in p85R274A-expressing cells alters PDGFR trafficking. in Cellular signalling 2010
Cow (Bovine) Polyclonal RAB5 Primary Antibody for ICC, IF - ABIN361846
Ali, Wasmeier, Lamoreux, Strom, Seabra: Multiple regions contribute to membrane targeting of Rab GTPases. in Journal of cell science 2004
Show all 7 Pubmed References
Human Polyclonal RAB5 Primary Antibody for IP, WB - ABIN1742215
Perlini, Botti, Fornasiero, Giannandrea, Bonanomi, Amendola, Naldini, Benfenati, Valtorta: Effects of phosphorylation and neuronal activity on the control of synapse formation by synapsin I. in Journal of cell science 2011
Human Monoclonal RAB5 Primary Antibody for ICC, IP - ABIN1742214
Seipold, Damme, Prox, Rabe, Kasparek, Sedlacek, Altmeppen, Willem, Boland, Glatzel, Saftig: Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein. in Biochimica et biophysica acta 2016
Cow (Bovine) Polyclonal RAB5 Primary Antibody for IHC, WB - ABIN2786773
Coyne, Shen, Turner, Bergelson: Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5. in Cell host & microbe 2007
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The results were indicative that rabies virus N proficiently colocalized with Rab5/EEA1 (show EEA1 Antibodies) and Rab7 (show RAB7B Antibodies)/LAMP1 (show LAMP1 Antibodies) in both cell lines at 24 and 48 h post-infection, while N titers significantly decreased in early infection of rabies virus.
Membrane localization and dynamics of geranylgeranylated Rab5 hypervariable region has been reported.
study elucidated a novel Malat1-miR-101-STMN1/RAB5A/ATG4D regulatory network that Malat1 activates autophagy and promotes cell proliferation by sponging miR-101 and upregulating STMN1, RAB5A and ATG4D expression in glioma cells
In conclusion, mutant KRAS promotes endosomal degradation in PDAC cell lines, which is impaired by KRAS silencing. Moreover, KRAS silencing activates RAB5A upregulation and drives PDAC subtype-dependent modulation of endosome trafficking.
siRNA knockdown of Rab5a or overexpression of miR (show MLXIP Antibodies)-494 in human macrophages significantly inhibits the survival of the parasites
our results show that Rab5a is overexpressed in pancreatic cancer and promotes aggressive biological behavior through regulation of the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway.
CMTM3 (show CMTM3 Antibodies) decreases EGFR (show EGFR Antibodies) expression, facilitates EGFR (show EGFR Antibodies) degradation, and inhibits the EGF (show EGF Antibodies)-mediated tumorigenicity of gastric cancer cells by enhancing Rab5 activity.
High RAS-associated protein (show RGL2 Antibodies) RAB5 expression correlated with the presence of lymphatic invasion and venous invasion and low E-cadherin (show CDH1 Antibodies) expression.
downregulated Rab5a led to slowed cell growth, decreased numbers of migrated cells, decreased numbers of cells at the G0G1 phase and a higher apoptosis rate. However, PDGF (show PDGFA Antibodies) significantly rescued these phenomena caused by siRNA against Rab5a
results suggest a new mechanism in which Rab5 induces a change in flexibility of EEA1 (show EEA1 Antibodies), generating an entropic collapse force that pulls the captured vesicle towards the target membrane to initiate docking and membrane fusion
SH3GLB1 (show SH3GLB1 Antibodies) controls nicotinic acetylcholine receptors endocytic trafficking in a phosphorylation- and RAB5-dependent manner at steps upstream of autophagosome formation.
E. chaffeensis secretes Etf-1 (show ETF1 Antibodies) to induce autophagy to repurpose the host cytoplasm and capture nutrients for its growth through RAB5 and class III PtdIns3K, while avoiding autolysosomal killing.
These data highlight a requirement of Rab5 and the endosomal system for the regulation of gluconeogenic gene expression that has important implications for metabolic diseases.
Inpp5e (show INPP5E Antibodies), through functional interactions with Rab20 (show RAB20 Antibodies) on the phagosome, activates Rab5, which, in turn, increases PtdIns3P and delays phagosome acidification.
FGF21 (show FGF21 Antibodies) has a role in promoting endothelial cell angiogenesis through a dynamin-2 (show DNM2 Antibodies) and Rab5 dependent pathway
In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin (show NCDN Antibodies) palmitoylation in its targeting to Rab5-positive endosomes.
In mammalian cells, p110beta acts as a molecular sensor for growth factor availability and induces autophagy by activating a Rab5-mediated signaling cascade.
Data show that Rinl is closely associated with the cytoskeleton and thus contributes to the spatial control of Rab5a and Rab22 signaling at actin-positive compartments.
Data reveal the affinity of Rabex-5 (show RABGEF1 Antibodies)/Rabaptin-5 (show RABEP1 Antibodies)/Rab5-GTP (show AK3 Antibodies) interaction in the cell, which is quantitatively related to the Rabex-5 (show RABGEF1 Antibodies) concentration for the onset of the indirect
Rab5 regulates and coordinates different endocytic mechanisms through its effector Rabankyrin-5 (show ANKFY1 Antibodies)
Expression of dominant negative Rab5 and Rab7 (show RAB7A Antibodies) mutants, but not the dominant negative Rab11 (show RAB11A Antibodies) mutant, significantly inhibited classical swine fever virus replication. These results were confirmed by silencing of Rab5 and Rab7 (show RAB7A Antibodies).
Dominant-negative mutant rab5 inhibits FMDV infection of IBRS-2 cells.
Required for the fusion of plasma membranes and early endosomes (By similarity).
, Rab5a, GTPase
, hypothetical protein
, Ras-related protein Rab-5A
, ras-related protein rab-5a
, RAB5A, member RAS oncogene family
, ras-related protein Rab-5A
, RAS-associated protein RAB5A
, small GTP-binding protein rab5
, GTP-binding protein (rab5)