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This study shown rare Genetic Variant in SORL1 May Increase Penetrance of Alzheimer's Disease in a Family with Several Generations of APOE (show APOE Proteins)-varepsilon4 Homozygosity.
The C allele in SORL1 was found to be a protective factor for late-onset Alzheimer's disease in both Caucasian and Han Chinese.
Report altered hippocampal functional connectivity in carriers with risk APOE (show APOE Proteins) epsilon4 or SORL1 G-allele, which may predispose these risk-allele carriers to be susceptible for Alzheimer disease.
There was no significant association between single nucleotide polymorphisms (SNPS) of GAB2 (show GAB2 Proteins) rs2373115 (G > T) and PICALM (show PICALM Proteins) rs541458 (C > T) and Alzheimer's disease (AD). The allele T of rs3851179 in PICALM (show PICALM Proteins) was associated with a 13 % increase in the risk of AD. Seven SNPs on SORL1 were significantly associated with AD.
SORL1 variations influence the atrophy of specific Alzheimer disease-related brain structures, suggesting the potential role of SORL1 in the neurodegeneration of cognitive related regions.
These findings elucidate how the SORL1 variants shape the neural system to modulate age-related cognitive decline and support the hypothesis that SORL1 may represent a candidate gene for late-onset Alzheimer's disease.
These results demonstrate a novel role for SORLA as a physiological and pathological EphA4 (show EPHA4 Proteins) modulator.
Using three different patient cohorts of early onset Alzheimer disease (AD), study describes three SORL1 variants that segregate with disease in three families adding to the literature which supports SORL1 as a major player in AD pathoetiology.
SORL1 variant characteristics associated with variant pathogenicity were identified in Alzheimer disease cohort.
The results of this study support the effect of SORL1 gene on the disease risks and pathognomonic surrogates of Alzheimer's disease and mild cognitive impairment.
Results demonstrate that the lack of SORLA results in accumulation of phosphorylated synapsins in cortex and hippocampus. Authors propose an underlying molecular mechanism by demonstrating that SORLA interacts with phosphorylated synapsins through 14-3-3 adaptor proteins to deliver synapsins to calpain-mediated proteolytic degradation.
Analysis of the molecular mechanism for the association of SORL1 with obesity: there is a genetic link between neurodegeneration and metabolism that converges on the receptor SORLA
SorLA ectodomain, released from the cell membrane upon enzymatic cleavage of full-length SorLA, may act as an IL-6 (show IL6 Proteins) carrier protein that stabilizes IL-6 (show IL6 Proteins) and its capacity for trans signaling.
We identify binding and trafficking interactions between two of these factors, SORLA and SNX27 (show SNX27 Proteins), and demonstrate that SNX27 (show SNX27 Proteins) can direct trafficking of SORLA and the Abeta (show APP Proteins) precursor APP (show APP Proteins) to the cell surface to limit the production of Abeta (show APP Proteins). Diversion APP (show APP Proteins) to the cell surface through modulation of this molecular complex may represent a complimentary strategy for future development in AD treatment.
LR11 regulated vascular smooth muscle cell proliferation during the progression of hypoxia-induced medial thickening in mice.
Therefore, SORL1 activation by 6-shogaol provides neuronal cell survival through the inhibition of Abeta (show APP Proteins) production. These results indicate that 6-shogaol should be regarded as an SORL1 activator and a potential preventive agent for the treatment of AD.
Data strongly suggest an involvement of LR11 in mediating the harmful effects of a high-fat diet on CVD progression.
Mice lacking LR11 are protected from diet-induced obesity associated with an increased browning of white adipose tissue and hypermetabolism.
using massively parallel reporter assays, we dissect the enhancer activity of three liver eExons (SORL1 exon 17, TRAF3IP2 (show TRAF3IP2 Proteins) exon 2, PPARG (show PPARG Proteins) exon 6) at single nucleotide resolution in the mouse liver
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.
sortilin-related receptor, L(DLR class) A repeats containing
, sortilin-related receptor, L(DLR class) A repeats-containing
, sortilin-related receptor-like
, LDLR relative with 11 ligand-binding repeats
, low-density lipoprotein receptor relative with 11 ligand-binding repeats
, mosaic protein LR11
, sortilin-related receptor
, sorting protein-related receptor containing LDLR class A repeats