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These findings show that control of Lhx2 function by Ldb1 and Rnf12 underpins the coordinated differentiation of neurons and Muller glia in postnatal retina.
Both LDB1 and CTCF are required for enhancer-Car2 looping, and the domain of LDB1 contacted by CTCF is necessary to rescue Car2 transcription in LDB1-deficient cells.
Animals lacking both Ldb1 and Ldb2 uncover the requirement for Ldb2 during corticospinal motor neuron differentiation
Data show that mediator is recruited to the beta-globin locus by the LDB1 complex.
Genome-wide analysis indicated that LMO2 is required at the hemangioblast stage to position the TAL1/LMO2/LDB1 complex to regulatory elements that are important for the establishment of the hematopoietic developmental program.
LDB1 regulates energy homeostasis, in part through transcriptional modulation of critical regulators in brown adipose tissue function.
an essential cell-autonomous role for Ldb1 in the development of dopaminergic neurons, is reported.
An intricate regulatory network exists that is mediated by Ldb1 and Ldb2, and promotes retinal progenitor cells proliferation and multipotency; it also controls specification of mammalian retina cells.
LDB1 maintains the terminally differentiated state of beta cells and is a component of active enhancers in both murine and human islets.
CLIM interacts with estrogen receptor alpha at the H19 locus, potentially explaining the higher expression of H19 in female than male corneas.
SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic beta-Cell Target Genes
the Isl1/Ldb1 complex orchestrates a network for heart-specific transcriptional regulation and coordination in three-dimensional space during cardiogenesis.
results indicate that LDB1-dependent looping events can deliver repressive cargo to cognate promoters to mediate promoter pausing events in a pituitary cell type
Expression pattern of Isl1 and its co-factor Ldb1, were analyzed in small intestine.
Data suggest that the function of LIM domain binding protein 1 (LDB1) in the neural crest-derived palatal mesenchyme is essential for normal morphogenesis of the secondary palate.
the LDB1 dimerization domain (DD) is necessary and, when fused to LMO2, sufficient to completely restore LCR-promoter looping and transcription in LDB1-depleted cells
Ldb1 plays an essential role as a transcription co-regulator of Lhx6 and Lhx8 in the control of mammalian telencephalon development.
These results provide a foundation for defining the mechanism and scope of Ldb1 complex activity during erythropoiesis.
Data indicte that the regulation of essential developmental factors by Ldb1 defines it as an upstream transcriptional regulator of hematopoietic/endothelial development.
Isl1 and the Ldb co-regulators of transcription are essential early determinants of mouse limb development
Data indicate that LIM-domain-binding protein 1 (LDB1) has a strong role in colorectal cancer (CRC) progression.
Alanine scanning mutagenesis of the LIM interaction domain of LDB1 revealed a discrete motif, R(320)LITR, required for LMO2 binding.
Clim2, in a complex with LMO4, supports mammary stem cells by directly targeting the Fgfr2 promoter in basal cells to increase its expression
In t(8;21) leukemia cells, LDB1 functions as a component of the stable AML1-ETO-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis.
We investigated NLI (Ldb1 homolog) complex occupancy and chromatin conformation of the beta-globin locus in human erythroid cells.
These studies are consistent with a model in which TIF1gamma acts to ubiquitinate LDB1 leading to degradation of LDB1 and changes in transcription of LDB1-dependent promoters.
Expression of LDB1 (LIM-domain-binding 1) protein in which Lys134 is replaced with arginine leads to enhanced expression of the mutant protein compared with the wild-type protein.
1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex
Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development
characterize the assembly of a five-component complex containing TAL1, LMO2, Ldb1, E12, and DNA. The bHLH domains of TAL1 and E12 alone primarily formed helical homodimers, but together formed heterodimers, to which LMO2 bound with high affinity
Although the LIM interaction domain of Ldb1 (Ldb1(LID)) and Isl1(LBD) share low levels of sequence homology, X-ray and NMR structures reveal that they bind Lhx3 in an identical manner, that is, Isl1(LBD) mimics Ldb1(LID).
The functional cloning, expression pattern, overexpression, and knockdown data show that an ldb1-regulated mechanism acts as an early signal for Xenopus lens induction.
Centrosome movements in vivo correlate with specific neurite formation downstream of LIM homeodomain transcription factor activity.
Study identifies a number of novel Ldb1 interacting proteins in murine erythroleukaemic cells, namely Eto-2, the cyclin-dependent kinase Cdk9, Lmo4; morphilino-mediated knockdowns in zebrafish show these factors to be essential for haematopoiesis.
Ldb4b (splice isoform lacking LID) is localized in the nucleus when expressed in mammalian culture cells, and binds to Ldb4a (splice isoform containing LID) but not directly to LIM proteins.
Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors.
, LIM domain-binding factor CLIM2
, LIM domain-binding protein 1
, carboxyl-terminal LIM domain-binding protein 2
, nuclear LIM interactor
, LIM domain-binding factor-1
, carboxy terminal LIM domain protein 2
, neural Src-interacting protein
, neural src interacting protein
, LIM-domain binding factor 1
, LIM domain-binding protein 1-A
, LIM domain-binding protein 4
, LIM-domain binding factor 4
, LIM-domain binding factor 4b