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The functional cloning, expression pattern, overexpression, and knockdown data show that an ldb1-regulated mechanism acts as an early signal for Xenopus lens induction.
These findings show that control of Lhx2 (show LHX2 Proteins) function by Ldb1 and Rnf12 (show RLIM Proteins) underpins the coordinated differentiation of neurons and Muller glia in postnatal retina.
Both LDB1 and CTCF (show CTCF Proteins) are required for enhancer-Car2 (show CA2 Proteins) looping, and the domain of LDB1 contacted by CTCF (show CTCF Proteins) is necessary to rescue Car2 (show CA2 Proteins) transcription in LDB1-deficient cells.
Animals lacking both Ldb1 and Ldb2 (show LDB2 Proteins) uncover the requirement for Ldb2 (show LDB2 Proteins) during corticospinal motor neuron differentiation
Data show that mediator is recruited to the beta-globin (show HBB Proteins) locus by the LDB1 complex.
Genome-wide analysis indicated that LMO2 (show LMO2 Proteins) is required at the hemangioblast stage to position the TAL1 (show TAL1 Proteins)/LMO2 (show LMO2 Proteins)/LDB1 complex to regulatory elements that are important for the establishment of the hematopoietic developmental program.
LDB1 regulates energy homeostasis, in part through transcriptional modulation of critical regulators in brown adipose tissue function.
an essential cell-autonomous role for Ldb1 in the development of dopaminergic neurons, is reported.
An intricate regulatory network exists that is mediated by Ldb1 and Ldb2 (show LDB2 Proteins), and promotes retinal progenitor cells proliferation and multipotency; it also controls specification of mammalian retina cells.
LDB1 maintains the terminally differentiated state of beta cells and is a component of active enhancers in both murine and human islets.
CLIM interacts with estrogen receptor alpha (show ESR1 Proteins) at the H19 (show NCKAP1 Proteins) locus, potentially explaining the higher expression of H19 (show NCKAP1 Proteins) in female than male corneas.
Data indicate that LIM-domain-binding protein 1 (LDB1) has a strong role in colorectal cancer (CRC (show CALR Proteins)) progression.
SSBP3 (show SSBP3 Proteins) Interacts With Islet-1 (show ISL1 Proteins) and Ldb1 to Impact Pancreatic beta-Cell Target Genes
Alanine scanning mutagenesis of the LIM (show PDLIM5 Proteins) interaction domain of LDB1 revealed a discrete motif, R(320)LITR, required for LMO2 (show LMO2 Proteins) binding.
Clim2, in a complex with LMO4 (show LMO4 Proteins), supports mammary stem cells by directly targeting the Fgfr2 (show FGFR2 Proteins) promoter in basal cells to increase its expression
In t(8;21) leukemia cells, LDB1 functions as a component of the stable AML1 (show RUNX1 Proteins)-ETO (show RUNX1T1 Proteins)-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis.
We investigated NLI (Ldb1 homolog) complex occupancy and chromatin conformation of the beta-globin (show HBB Proteins) locus in human erythroid cells.
These studies are consistent with a model in which TIF1gamma (show TRIM33 Proteins) acts to ubiquitinate LDB1 leading to degradation of LDB1 and changes in transcription of LDB1-dependent promoters.
Expression of LDB1 (LIM-domain-binding 1) protein in which Lys134 is replaced with arginine leads to enhanced expression of the mutant protein compared with the wild-type protein.
1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4 (show LMO4 Proteins):ldb1 complex
Centrosome movements in vivo correlate with specific neurite formation downstream of LIM homeodomain transcription factor activity.
Study identifies a number of novel Ldb1 interacting proteins in murine erythroleukaemic cells, namely Eto-2 (show CBFA2T3 Proteins), the cyclin-dependent kinase (show CDK1 Proteins) Cdk9 (show CDK9 Proteins), Lmo4 (show LMO4 Proteins); morphilino-mediated knockdowns in zebrafish show these factors to be essential for haematopoiesis.
Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors.
, LIM domain-binding factor CLIM2
, LIM domain-binding protein 1
, carboxyl-terminal LIM domain-binding protein 2
, nuclear LIM interactor
, neural Src-interacting protein
, neural src interacting protein
, LIM domain-binding factor-1
, carboxy terminal LIM domain protein 2
, LIM-domain binding factor 1