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anti-Human PRDM16 Antibodies:
anti-Mouse (Murine) PRDM16 Antibodies:
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Human Polyclonal PRDM16 Primary Antibody for ELISA - ABIN249627
Stanford, Middelbeek, Townsend, An, Nygaard, Hitchcox, Markan, Nakano, Hirshman, Tseng, Goodyear: Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. in The Journal of clinical investigation 2013
Show all 2 Pubmed References
Human Polyclonal PRDM16 Primary Antibody for ELISA, ICC - ABIN4347210
Baskaran, Krishnan, Ren, Thyagarajan: Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms. in British journal of pharmacology 2016
Prdm3 (show MECOM Antibodies) and prdm16 are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.
Animals with the homozygote PRDM16 genotype had lower body weight and average daily gain than those with the other genotypes.
The genetic variation within PRDM16 gene in 1031 Chinese indigenous bovine, was analyzed.
Multiple regression analysis showed that age, male gender, body max index, presence of obesity, type-2-diabetes mellitus, hypertension and coronary artery disease and left ventricular ejection fraction were associated with the expression levels of UCP1 (show UCP1 Antibodies), PGC1alpha and PRDM16 mRNA
Our study suggests that the MEF2D (show MEF2D Antibodies), PRDM16 and ASTN2 (show ASTN2 Antibodies) genes from GWAS are associated with migraine susceptibility, especially migraine without aura (show AURKA Antibodies) , among Chinese patients. It appears that there is no association with serotonin receptor (show HTR1B Antibodies) related genes.
High PRDM16 expression is a significant predictive marker for poor prognosis in adult AML (show RUNX1 Antibodies) patients.
Prdm16 interacts with the transcription factor Hlx (show HLX Antibodies), which is stabilized in response to beta3-adrenergic signaling, to increase thermogenic gene expression and mitochondrial biogenesis in subcutaneous WAT.
Flow cytometric analysis and western blot analysis of apoptosisassociated proteins indicated that PRDM16 has an antiapoptotic role in prostatic cancer cells. In addition, the spliced form, sPRDM16/MEL1S, was detected to be overexpressed in PCa (show FLVCR1 Antibodies) cell lines. In conclusion, the present study indicated an important oncogenic role in prostate cancer.
A single risk variant, rs2651899 in PRDM16, was significantly associated with efficacy of triptans in migraine patients
High PRDM16 expression is associated with astrocytoma.
Our results suggest that K568 SUMOylation of sPRDM16 plays an important role in the progression of acute myeloid leukemia (show BCL11A Antibodies).
Results show that PRDM16 overexpression was highly recurrent in de novo paediatric AML (show RUNX1 Antibodies) and is associated with adverse outcome
PRDM16 might contribute to maintain adipose tissue "white fat" gene expression profile and systemic metabolic homeostasis.
Consecutive breeding to Flpe and Emx1 (show EMX1 Antibodies)(IREScre) deleter mice spatially restricted Prdm16 loss to regions of the forebrain expressing the homeobox (show PRRX1 Antibodies) gene Emx1 (show EMX1 Antibodies).
Prdm16 is required for adult neural stem cell maintenance and neurogenesis as well as the formation of ependymal cells
A single subtype of ganglion cell appears to be uniquely marked by Prdm16 expression. While the precise identity of these ganglion cells is unclear, they most resemble the G9 subtype described by Volgyi and colleagues in 2009.
Gelidium elegans stimulates the expression of PRDM16 and UCP-1 (show UCP1 Antibodies) Protein in brown adipose tissue and suppresses hyperglycemia in high-fat diet mice.
Both gain- and loss-of-function studies showed that an accumulation of the CCAAT/enhancer binding protein-beta (C/EBP-beta (show CEBPB Antibodies)) protein, which cooperates with dominant transcriptional co-regulator PR domain containing 16 (PRDM16) to determine brown/beige (show LYST Antibodies) adipocyte lineage, is essential for the enhanced adipocyte browning caused by the loss of ZIP13 (show SLC39A13 Antibodies)
Prdm16 plays an important role in dynamic cellular redox changes in developing neocortex during neural differentiation.
Together, these data indicate that PRDM16 diminishes responsiveness to type I interferon (show IFNA Antibodies) in adipose cells to promote thermogenic and mitochondrial function.
the cellular levels of alpha-ketoglutarate (alphaKG), a key metabolite required for TET-mediated DNA demethylation, were profoundly increased and required for active DNA demethylation of the Prdm16 promoter.
We further show that Cdkn1c (show CDKN1C Antibodies) is required for post-transcriptional accumulation of the brown fat determinant PR domain containing 16 (PRDM16) and that CDKN1C (show CDKN1C Antibodies) and PRDM16 co-localise to the nucleus of rare label-retaining cell within iBAT (show SLC10A2 Antibodies).
The reciprocal translocation t(1\;3)(p36\;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
PR domain containing 16
, PR domain zinc finger protein 16-like
, MDS1/EVI1-like gene 1
, PR domain zinc finger protein 16
, transcription factor MEL1
, PR domain-containing protein 16
, line 27