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Study discovered a novel enhancer HER2 (show ERBB2 Proteins) gene body enhancer (HGE) in the 3' gene body of HER2 (show ERBB2 Proteins). The HGE activates promoters 1 and 2 in trans., and hence the TFAP2C-mediated transcriptional induction of HER2 (show ERBB2 Proteins) expression in breast cancer samples.
This study shows that TFAP2C promoted lung tumor progression by upregulation of TGFBR1 (show TGFBR1 Proteins) and consequent activation of PAK1 (show PAK1 Proteins) signaling.
miR (show MLXIP Proteins)-137 is a Slug-induced miRNA that relays the pro-metastatic effects of Slug by targeting TFAP2C in non-small cell lung cancer cells.
TFAP2C might increase oncogenic miR (show MLXIP Proteins)-183 expression and consequently downregulate tumor-suppressive AKAP12 and decrease tumor-suppressive miR (show MLXIP Proteins)-33a expression and subsequently induce CDK6 (show CDK6 Proteins) in NSCLC cells.
Higher TFAP2C protein expression correlates with poor overall survival after 10 years of diagnosis in ERalpha (show ESR1 Proteins)-positive breast cancer.
TFAP2C has an important role in regulated luminal-specific genes and may be a viable therapeutic target in breast cancer.
ShRNA knockdown of AP-2gamma in neuroblastoma (show ARHGEF16 Proteins) cells results in significant inhibit of cell proliferation.
Knockdown of TFAP2C or RET (show RET Proteins) inhibited activation of ERK (show EPHB2 Proteins) and AKT (show AKT1 Proteins) in MCF-7 cells. Knockdown of TFAP2C, which controls ER (estrogen receptor (show ESR1 Proteins)) and RET (show RET Proteins), had a greater effect on cell growth than either RET (show RET Proteins) or ER alone.
role for TFAP2C in melanoma via its regulation of ECM1 (show ECM1 Proteins)
TFAP2C amplification and overexpression represents a genetic dependency in ERBB2 (show ERBB2 Proteins)+ve breast cancer.
Redundant activities of Tfap2a (show TFAP2A Proteins) and Tfap2c are required for neural crest induction and development of other non-neural ectoderm derivatives in zebrafish embryos.
Expression of TFAP2beta (show TFAP2B Proteins) and TFAP2gamma genes in Xenopus laevis.
Tfap2c expression is altered in early preimplantation SCNT embryos, which may have developmental consequences resulting from genes influenced by Tfap2c, but expression was not different at the blastocyst stage and in placentomes.
TFAP2C in trophoblasts controls proliferation by repressing Cdkn1a (show CDKN1A Proteins) and activating the MAPK (show MAPK1 Proteins) pathway, further supporting differentiation of glycogen (show GYS1 Proteins) cells by activating the AKT (show AKT1 Proteins) pathway
these findings indicate that a reduction in the gene dosage of placental Tfap2c leads to morphological changes in the labyrinth at midgestation
TFAP2C regulates tumorigenesis, cell growth and survival in HER2 (show ERBB2 Proteins)-amplified breast cancer through transcriptional regulation of EGFR (show EGFR Proteins).
Transcription factor AP-2gamma induces early Cdx2 (show CDX2 Proteins) expression and represses HIPPO signaling to specify the trophectoderm lineage.
we characterize the cis (show CISH Proteins)-regulatory organization of a large genomic locus consisting of Tfap2c and Bmp7 (show BMP7 Proteins). We show that this locus is structurally partitioned into two distinct domains by the constitutive action of a discrete transition zone
mice with a heterozygous deletion of the TFAP2C target gene Nanos3 are also prone to develop teratomas. These data highlight TFAP2C as a critical and dose-sensitive regulator of germ cell fate.
Tcfap2c is not required for Oct4 (show POU5F1 Proteins) silencing in mouse blastocysts, but may be necessary for the maintenance of Oct4 (show POU5F1 Proteins) expression during the 8 cell-to-morula transition.
critical roles for AP-2 (show TFAP2A Proteins) activity in retinogenesis, delineating the overlapping expression patterns of Tcfap2a (show TFAP2A Proteins), Tcfap2b (show TFAP2B Proteins), and Tcfap2c in the neural retina, and revealing a redundant requirement for Tcfap2a (show TFAP2A Proteins) and Tcfap2b (show TFAP2B Proteins) in horizontal and amacrine cell development
An important role for TCFAP2C, SMARCA4 (show SMARCA4 Proteins), and EOMES (show EOMES Proteins) in TS cell self-renewal.
Data suggest that Tcfap2c and Cdx2 (show CDX2 Proteins) cooperate to override the pluripotency program and establish the extraembryonic trophoblast maintenance program in murine embryos.
The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube.
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
, transcription factor AP-2 gamma
, transcription factor ap-2 gamma
, transcription factor AP-2 gamma-like
, activating enhancer binding protein 2 gamma
, activator protein 2 gamma
, activating enhancer-binding protein 2 gamma
, estrogen receptor factor 1
, transcription factor AP-2 gamma (activating enhancer-binding protein 2 gamma)
, transcription factor ERF-1
, stimulated by retinoic acid gene 2