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Study discovered a novel enhancer HER2 gene body enhancer (HGE) in the 3' gene body of HER2. The HGE activates promoters 1 and 2 in trans., and hence the TFAP2C-mediated transcriptional induction of HER2 expression in breast cancer samples.
This study shows that TFAP2C promoted lung tumor progression by upregulation of TGFBR1 and consequent activation of PAK1 signaling.
miR-137 is a Slug-induced miRNA that relays the pro-metastatic effects of Slug by targeting TFAP2C in non-small cell lung cancer cells.
TFAP2C might increase oncogenic miR-183 expression and consequently downregulate tumor-suppressive AKAP12 and decrease tumor-suppressive miR-33a expression and subsequently induce CDK6 in NSCLC cells.
Higher TFAP2C protein expression correlates with poor overall survival after 10 years of diagnosis in ERalpha-positive breast cancer.
In all three groups[preeclamptic placentas , healthy control and smokers] expression rates of AP-2gamma did not differ between primary, secondary and tertiary villi.
TFAP2C has an important role in regulated luminal-specific genes and may be a viable therapeutic target in breast cancer.
ShRNA knockdown of AP-2gamma in neuroblastoma cells results in significant inhibit of cell proliferation.
Knockdown of TFAP2C or RET inhibited activation of ERK and AKT in MCF-7 cells. Knockdown of TFAP2C, which controls ER (estrogen receptor) and RET, had a greater effect on cell growth than either RET or ER alone.
role for TFAP2C in melanoma via its regulation of ECM1
TFAP2C amplification and overexpression represents a genetic dependency in ERBB2+ve breast cancer.
TFAP2C regulates expression of the RET proto-oncogene through five AP-2 regulatory sites in the RET promoter.
Results demonstrate that TFAP2C regulates the expression of GPX1, which influences the redox state and sensitivity to oxidative stress induced by peroxides.
ESDN and AP-2g expression is lower in thick melanomas, it is associated with unfavourable histo-pathological parameters (increased vascularity, vascular invasion and mitoses) and correlates with a shorter DFS like for AP-2a.
results substantiate a role for Tcfap2c/ TFAP2C in supporting proliferation and repressing differentiation in cellular compartments representing immature/ progenitor cells.[review]
We demonstrated that TFAP-2gamma is one of the transcription factors involved in the HuPAR-2 expression in human villous trophoblast cells.
demonstrated that while TFAP2C and Myc can downregulate the CDKN1A promoter independently, KDM5B acts as a corepressor dependent on the other two proteins
AP-2gamma is a novel collaborative factor in ERalpha-mediated transcription.
miR-214 is highly expressed in human melanomas and the data suggest a critical role for this miRNA in disease progression and the establishment of distant metastases through suppression of TFAP2C.
Overexpression of TFAP2C is associated with hormone responsive breast carcinoma.
Redundant activities of Tfap2a and Tfap2c are required for neural crest induction and development of other non-neural ectoderm derivatives in zebrafish embryos.
Expression of TFAP2beta and TFAP2gamma genes in Xenopus laevis.
Tfap2c expression is altered in early preimplantation SCNT embryos, which may have developmental consequences resulting from genes influenced by Tfap2c, but expression was not different at the blastocyst stage and in placentomes.
TFAP2C in trophoblasts controls proliferation by repressing Cdkn1a and activating the MAPK pathway, further supporting differentiation of glycogen cells by activating the AKT pathway
these findings indicate that a reduction in the gene dosage of placental Tfap2c leads to morphological changes in the labyrinth at midgestation
TFAP2C regulates tumorigenesis, cell growth and survival in HER2-amplified breast cancer through transcriptional regulation of EGFR.
Tcfap2c acts in a hierarchy to facilitate blastocyst formation through transcriptional regulation of core genes involved in tight junction assembly, fluid accumulation and cellular proliferation
Transcription factor AP-2gamma induces early Cdx2 expression and represses HIPPO signaling to specify the trophectoderm lineage.
we characterize the cis-regulatory organization of a large genomic locus consisting of Tfap2c and Bmp7. We show that this locus is structurally partitioned into two distinct domains by the constitutive action of a discrete transition zone
mice with a heterozygous deletion of the TFAP2C target gene Nanos3 are also prone to develop teratomas. These data highlight TFAP2C as a critical and dose-sensitive regulator of germ cell fate.
Tcfap2c is not required for Oct4 silencing in mouse blastocysts, but may be necessary for the maintenance of Oct4 expression during the 8 cell-to-morula transition.
critical roles for AP-2 activity in retinogenesis, delineating the overlapping expression patterns of Tcfap2a, Tcfap2b, and Tcfap2c in the neural retina, and revealing a redundant requirement for Tcfap2a and Tcfap2b in horizontal and amacrine cell development
results substantiate a role for Tcfap2c/ TFAP2C in supporting proliferation and repressing differentiation in cellular compartments representing immature/ progenitor cells[review]
study demonstrated clearly that nuclear expression of transcription factor Ap-2gamma is a useful marker for identifying undifferentiated male germ cells
In intestine, Tcfap2c induced cellular hyperplasia and suppressed terminal differentiation indicating that Tcfap2c serves as a repressor of differentiation and inducer of proliferation.
Expression of AP-2gamma transcription factors in breast cancer cells supports proliferation and contributes to chemo- and radiation-resistance of tumor cells by impairing the ability to induce apoptosis.
AP-2gamma is functionally involved in branching morphogenesis of the mammary epithelium, possibly by controlling genetic processes downstream of ovarian hormones
An important role for TCFAP2C, SMARCA4, and EOMES in TS cell self-renewal.
Data suggest that Tcfap2c and Cdx2 cooperate to override the pluripotency program and establish the extraembryonic trophoblast maintenance program in murine embryos.
important effector of Prdm1 activity that is required for primordial germ cell maintenance
AP-2 gamma and Dlx 3, together with an additional transcription factor(s) that are conserved between humans and mice, are required for trophoblast-specific expression of 3 beta-HSD VI.
Transcription factor gene AP-2 gamma essential for early murine development
essential in the extra-embryonic lineages for early postimplantation development
The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube.
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
, transcription factor AP-2 gamma
, transcription factor ap-2 gamma
, transcription factor AP-2 gamma-like
, activating enhancer binding protein 2 gamma
, activator protein 2 gamma
, activating enhancer-binding protein 2 gamma
, estrogen receptor factor 1
, transcription factor AP-2 gamma (activating enhancer-binding protein 2 gamma)
, transcription factor ERF-1
, stimulated by retinoic acid gene 2