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Human Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 (CYP3A5) interaction partners

1. Our meta-analysis identified a positive correlation between CYP3A5 genotypes and tacrolimus pharmacokinetics in pediatric renal-transplant recipients

2. Younger age, POR (show POR Antibodies)*28 allele, and CYP3A5*3 allele were associated with higher cyclosporine dosing requirements and lower concentration/dose ratio.

3. Stability of the dose-adjusted trough concentrations achieved using modified-release once-daily tacrolimus, which was clearly influenced by the CYP3A5 polymorphism, may prevent the development of rejection.

4. African-American kidney transplant recipients with the CYP3A5*1 variant require higher tacrolimus dosing.

5. The combined CYP3A4 (show CYP3A4 Antibodies) and CYP3A5 genotype of renal transplant recipients has a major influence on the Tacrolimus dose required to reach the target exposure.

6. the plasma trough concentration/dose (C/D) ratio of apixaban was used as a pharmacokinetic index and all data were stratified according to the presence of ABCB1 (ABCB1 (show ABCB1 Antibodies) 1236C>T, 2677G>T/A, and 3435C>T), ABCG2 (ABCG2 421C>A), and CYP3A5 (CYP3A5*3) .These results indicate that ABCG2 421A/A and CYP3A5*3 genotypes and renal function are considered potential factors affecting trough concentrations of apixaban.

7. our findings suggest that CYP1A2 (show CYP1A2 Antibodies), CYP3A4 (show CYP3A4 Antibodies) and CYP3A5 play an important role in osteosarcoma tumorigenesis, at primary and metastatic sites, as well in treatment response

8. Patients with both CYP3A5*3/*3 and MDR1 (show TBC1D9 Antibodies) G2677A who underwent renal transplantation had higher blood TAC (show IL2RA Antibodies) concentrations than those without those genotypes. Japanese patients should be carefully monitored for consideration of lower TAC (show IL2RA Antibodies) doses, because 24% of Japanese patients have double mutations.

9. Among two SNPs in CYP3A4 (show CYP3A4 Antibodies) and CYP3A5 and 12 SNPs in ABCB1 (show ABCB1 Antibodies) gene, an association with ovarian cancer risk was observed for ABCB1 (show ABCB1 Antibodies) rs2157926 SNP only.

10. Donor CYP3A5 genotype, recipient age and, to a lesser extent, donor gender appear to be associated with tacrolimus disposition on day 1 after transplant