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Our meta-analysis identified a positive correlation between CYP3A5 genotypes and tacrolimus pharmacokinetics in pediatric renal-transplant recipients
Younger age, POR (show POR Antibodies)*28 allele, and CYP3A5*3 allele were associated with higher cyclosporine dosing requirements and lower concentration/dose ratio.
Stability of the dose-adjusted trough concentrations achieved using modified-release once-daily tacrolimus, which was clearly influenced by the CYP3A5 polymorphism, may prevent the development of rejection.
African-American kidney transplant recipients with the CYP3A5*1 variant require higher tacrolimus dosing.
The combined CYP3A4 (show CYP3A4 Antibodies) and CYP3A5 genotype of renal transplant recipients has a major influence on the Tacrolimus dose required to reach the target exposure.
the plasma trough concentration/dose (C/D) ratio of apixaban was used as a pharmacokinetic index and all data were stratified according to the presence of ABCB1 (ABCB1 (show ABCB1 Antibodies) 1236C>T, 2677G>T/A, and 3435C>T), ABCG2 (ABCG2 421C>A), and CYP3A5 (CYP3A5*3) .These results indicate that ABCG2 421A/A and CYP3A5*3 genotypes and renal function are considered potential factors affecting trough concentrations of apixaban.
our findings suggest that CYP1A2 (show CYP1A2 Antibodies), CYP3A4 (show CYP3A4 Antibodies) and CYP3A5 play an important role in osteosarcoma tumorigenesis, at primary and metastatic sites, as well in treatment response
Patients with both CYP3A5*3/*3 and MDR1 (show TBC1D9 Antibodies) G2677A who underwent renal transplantation had higher blood TAC (show IL2RA Antibodies) concentrations than those without those genotypes. Japanese patients should be carefully monitored for consideration of lower TAC (show IL2RA Antibodies) doses, because 24% of Japanese patients have double mutations.
Among two SNPs in CYP3A4 (show CYP3A4 Antibodies) and CYP3A5 and 12 SNPs in ABCB1 (show ABCB1 Antibodies) gene, an association with ovarian cancer risk was observed for ABCB1 (show ABCB1 Antibodies) rs2157926 SNP only.
Donor CYP3A5 genotype, recipient age and, to a lesser extent, donor gender appear to be associated with tacrolimus disposition on day 1 after transplant
This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene. Multiple alternatively spliced transcript variants have been identified for this gene.
cytochrome P450 3A5
, aryl hydrocarbon hydroxylase
, cytochrome P450 HLp2
, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5
, cytochrome P450-PCN3
, flavoprotein-linked monooxygenase
, microsomal monooxygenase
, xenobiotic monooxygenase