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Human Polyclonal SULT2B1 Primary Antibody for WB - ABIN1989522
Hu, Yang, Zhang, Feng, Zhai, Gong, Qi, Fu, Ye, Cai, Gao: Overexpression of SULT2B1b is an independent prognostic indicator and promotes cell growth and invasion in colorectal carcinoma. in Laboratory investigation; a journal of technical methods and pathology 2015
Cow (Bovine) Polyclonal SULT2B1 Primary Antibody for WB - ABIN2783445
He, Falany: Inhibition of SULT2B1b expression alters effects of 3beta-hydroxysteroids on cell proliferation and steroid hormone receptor expression in human LNCaP prostate cancer cells. in The Prostate 2007
Show all 2 Pubmed References
Mutation in SULT2B1 leads to an autosomal-recessive congenital ichthyosis (show LBR Antibodies) phenotype via increased proliferation of human keratinocytes, thickening of epithelial layers, and altered epidermal cholesterol metabolism.
Since 1'-hydroxyestragole exposure readily produced DNA injury in B-13/H cells, these data suggest that cholangiocarcinomas generated in rats fed estragole may be dependent, in part, on SULT2B1 activation of the 1'-hydroxyestragole metabolite.
Overexpression of SULT2B1b is an independent prognostic indicator and promotes cell growth and invasion in colorectal carcinoma.
This study identified specific germline variations in estradiol metabolism-related pathways, namely CYP1B1 (show CYP1B1 Antibodies), SULT2B1, and HSD17B2 (show HSD17B2 Antibodies), as novel prognostic markers that are cumulatively associated with increased risk of prostate cancer progression
The SULT2B1 isoforms have a unique 50 amino acid carboxy-terminal sequence that is not present in the other human SULT isoforms (review).
Data indicate that cholesterol sulfate (CS) and SULT2B1b inhibited gluconeogenesis by targeting the gluconeogenic factor hepatocyte nuclear factor 4alpha (HNF4alpha (show HNF4A Antibodies)) in both cell cultures and human SULT2B1b transgenic mice.
SULT2B1 is induced by calcitriol activated vitamin D receptor (show VDR Antibodies) in human prostate cancer cells.
SULT2B1b expression promotes proliferation of hepatocellular carcinoma cells in vitro and in vivo, which may contribute to the progression of HCC (show FAM126A Antibodies).
In HT29 cells expression of SULT2B1 was enhanced by probiotic fermentation supernatants without aleurone.
Sulfation of 25-hydroxycholesterol by SULT2B1b plays an important role in the maintenance of intracellular lipid homeostasis via the LXR (show NR1H3 Antibodies)/SREBP-1c (show SREBF1 Antibodies) signaling pathway in endothelial cells.
SULT2B1b may promote hepatocyte proliferation by inactivating oxysterol/LXR signaling.
increases in SULT2B1b expression were accompanied by reduction in key regulators and enzymes involved in lipid metabolism, including liver X receptor alpha (show NR1H3 Antibodies), SREBP-1 (show SREBF1 Antibodies), SREBP-2 (show SREBF2 Antibodies), acetyl-CoA carboxylase-1 (show ACACA Antibodies), and fatty acid synthase (show FASN Antibodies).
results suggested that the unique, extended proline/serine-rich C-terminus of SULT2B1b is important for its interaction with cytoskeletal proteins
Elevation of hepatic sulphotransferase activities in mice with resistance to cystic fibrosis (show S100A8 Antibodies)
during embryonic development, SULT2B1b is required for production of cholesterol sulfate essential for normal skin development
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described.
, alcohol sulfotransferase
, hydroxysteroid sulfotransferase 2
, sulfotransferase 2B1
, sulfotransferase family cytosolic 2B member 1
, sulfotransferase 2B
, sulfotransferase family, cytosolic, 2B, member 1
, cytosolic hydroxysteroid sulfotransferase 2b member 1