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|Antigen||Bone Morphogenetic Protein 7 (BMP7) Antibodies|
|Epitope||AA 293-431 Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This BMP7 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
|4 references available|
|Supplier||Log in to see|
Product Details anti-BMP7 AntibodyTarget Details BMP7 Application Details Handling References for anti-BMP7 antibody (ABIN121162) Images
|Specificity||This antibody reacts with BMP-7.|
|Purification||Protein-G affinity chromatography|
|Immunogen||Recombinant human BMP7 (293-431 aa) purified from E. coli|
|Plasmids, Primers & others|
Target Details BMP7Product Details anti-BMP7 Antibody Application Details Handling References for anti-BMP7 antibody (ABIN121162) Images back to top
|Alternative Name||BMP7 (BMP7 Antibody Abstract)|
|Background||BMP-7 (bone morphogenetic protein-7), also known as OP-1 (osteogenic protein-1), is a member of the transforming growth factor β (TGFβ) superfamily. BMP-7 plays an essential role during ontogeny of the mammalian eye and kidney, also, is expressed in heart, lung, small intestine, limb bud and teeth. In addition, noggin, one of the soluble BMP antagonists, regulated the action of BMPs on mesenchymal precursor cells, partially through a feedback type of inhibition.Synonyms: BMP-7, Bone morphogenetic protein 7, OP1, Osteogenic protein 1|
|Pathways||Steroid Hormone Mediated Signaling Pathway, Stem Cell Maintenance|
Application DetailsProduct Details anti-BMP7 Antibody Target Details BMP7 Handling References for anti-BMP7 antibody (ABIN121162) Images back to top
ELISA. Western blot (1/500 - 1/1,000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-BMP7 Antibody Target Details BMP7 Application Details References for anti-BMP7 antibody (ABIN121162) Images back to top
|Buffer||PBS, pH 7.4, containing 0.09 % Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.
|Expiry Date||12 months|
References for anti-BMP7 antibody (ABIN121162)Product Details anti-BMP7 Antibody Target Details BMP7 Application Details Handling Images back to top
Gregory, Ono, Charbonneau, Kuo, Keene, Bächinger, Sakai: "The prodomain of BMP-7 targets the BMP-7 complex to the extracellular matrix." in: The Journal of biological chemistry, Vol. 280, Issue 30, pp. 27970-80, 2005
Groppe, Greenwald, Wiater, Rodriguez-Leon, Economides, Kwiatkowski, Affolter, Vale, Izpisua Belmonte, Choe: "Structural basis of BMP signalling inhibition by the cystine knot protein Noggin." in: Nature, Vol. 420, Issue 6916, pp. 636-42, 2002
Godin, Takaesu, Robertson, Dudley: "Regulation of BMP7 expression during kidney development." in: Development (Cambridge, England), Vol. 125, Issue 17, pp. 3473-82, 1998
Sampath, Coughlin, Whetstone, Banach, Corbett, Ridge, Ozkaynak, Oppermann, Rueger: "Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily." in: The Journal of biological chemistry, Vol. 265, Issue 22, pp. 13198-205, 1990
ImagesProduct Details anti-BMP7 Antibody Target Details BMP7 Application Details Handling References for anti-BMP7 antibody (ABIN121162) back to top