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Results suggest that xCOUP-TF and xCyp26 (show CYP26A1 Proteins) are both regulated by Wnt (show WNT2 Proteins) signaling, and cooperatively function in retinoic acid (RA) signaling to affect anterior-posterior (A-P) neural patterning.
Both in zebrafish and Xenopus the development of the main lymphatic structures was severely hampered.
We showed that the orphan receptor (show NR1D2 Proteins) COUP-TFII is an important player in hepatic neoangiogenesis. COUP-TFII expression in hepatic stellate cells (HSC (show FUT1 Proteins)) controls the crosstalk between hepatic HSC (show FUT1 Proteins) and endothelial cells coordinating vascular remodelling during liver injury.
Low COUPTFII expression is associated with prostate cancer.
Whole-exome sequencing identified a novel missense NR2F1 (show NR2F1 Proteins) variant in each case, Cys86Phe in the DNA-binding domain in Case 1, and a Leu372Pro in the ligand-binding domain in Case 2. Using molecular modeling we are also able to demonstrate the putative effect of the two missenses on protein function, generating a hitherto undescribed molecular model for the ligand-binding domain of NR2F1 (show NR2F1 Proteins) in the process.
We conclude that COUP-TFII mutations can cause diaphragmatic hernias, and should be included in the differential diagnosis of CDH (show CHDH Proteins) patients, particularly those with comorbid congenital heart defects.
Studied the role of Nuclear receptor subfamily 2 group F member 2 (NR2F2) in MSC (show MSC Proteins) chondrogenesis in bioprinted cartilage. NR2F2 (show NR2F1 Proteins) over-expressed MSCs showed significantly enhanced chondrogenesis while NR2F2 (show NR2F1 Proteins) knockdown cells demonstrated the exactly opposite behavior.
NR2F2 (show NR2F1 Proteins) is a Direct Target Gene of miR (show MLXIP Proteins)-382 in colorectal cancer.
Results indicate that COUP-TFII may play an oncogenic role in RCC, and COUP-TFII may promote tumor progression through inhibiting BRCA1.
MicroRNA-27b was targeted and down-regulated by NR2F2 (show NR2F1 Proteins) in human gastric cancer tissues and cells.
NR2F2 (show NR2F1 Proteins) could promote TGF-beta (show TGFB1 Proteins)-induced epithelial-mesenchymal transition of colorectal carcinoma cells and inhibit Smad7 (show SMAD7 Proteins) expression via transactivation of miR (show MLXIP Proteins)-21.
NR2F2 (show NR2F1 Proteins) mediates BMMSCinduced proliferation of Reh (show CES1 Proteins) cells, partially via regulation of VEGFA (show VEGFA Proteins). Disrupting microenvironmental support by targeting NR2F2 (show NR2F1 Proteins) may be a potential therapeutic strategy for ALL.
elimination of Wolffian ducts in female embryos is actively promoted by COUP-TFII, which suppresses a mesenchyme-epithelium cross-talk responsible for Wolffian duct maintenance.
Together, these results imply that Tie2 (show TEK Proteins) is essential for venous specification and maintenance via Akt (show AKT1 Proteins) mediated stabilization of COUP-TFII.
Coup-TF1 (show NR2F1 Proteins) and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons
A regulatory role of COUP-TFII in the development of muscular dystrophy.
FGF2 (show FGF2 Proteins) is an extracellular inducer of COUP-TFII expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII expression prior to the onset of osteogenic differentiation
results identify a novel cooperation between MEF2 (show MEF2C Proteins) factors and NR2F2 in the expression of the Akr1c14 gene
These in vitro and in vivo data support an anti-adipogenic role of COUP-TFII via downregulating the Notch (show NOTCH1 Proteins) signaling target gene Hey1 (show HEY1 Proteins).
Myocardial Nr2f2 overexpression causes heart failure. Nr2f2 represses genes critical for mitochondrial ETC enzyme activity, oxidative stress detoxification and mitochondrial dynamics, resulting in increased ROS (show ROS1 Proteins) and lower rates of oxygen consumption.
Data show that Chicken ovalbumin upstream promoter transcription factor (show NR2F1 Proteins) II (COUP-TFII)-induced expression of Neuropilin-2 (Nrp2 (show NRP2 Proteins)) and its down-regulation control the destination of preoptic area (POa)-derived GABAergic neurons.
Sox7 (show SOX7 Proteins)/18 factors and Notch (show NOTCH1 Proteins) regulate nr2f2 gene expression during venous differentiation in zebrafish.
absence of NR2F2 in zebrafish resulted in distinct vascular defects including loss of venous marker expression, major trunk vessel fusion and vascular leakage.
Results show that chicken ovalbumin upstream promoter transcription factor (show NR2F1 Proteins) II (COUP-TFII), hepatocyte nuclear factor 4alpha (HNF-4alpha (show HNF4A Proteins)) and HNF-4gamma regulate growth hormone receptor (show GHR Proteins) 1A promoter activity by binding to a common DNA element
Involvement of Ad4BP/SF-1 (show NR5A1 Proteins), DAX-1 (show NR0B1 Proteins), and COUP-TFII transcription factor on steroid production and luteinization in ovarian theca cells.
This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants.
nuclear receptor subfamily 2, group F, member 2
, ADP-ribosylation factor related protein 1
, COUP transcription factor 2
, COUP transcription factor II
, apolipoprotein A-I regulatory protein 1
, apolipoprotein AI regulatory protein 1
, chicken ovalbumin upstream promoter transcription factor 2
, chicken ovalbumin upstream promoter-transcription factor I
, chicken ovalbumin upstream promoter-transcription factor II variant 1
, chicken ovalbumin upstream promoter-transcription factor II variant 2
, chicken ovalbumin upstream promoter-transcription factor II variant 3
, COUP-TF II
, apolipoprotein regulatory protein 1
, ovalbumin upstream promoter beta nuclear receptor
, seven-up related 40
, nuclear receptor subfamily 2 group F member 2
, apolipoprotein A1 regulatory protein 1
, nuclear receptor subfamily 2, group F, member 1
, transcription factor COUP 2