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we present evidence that, during learning, the translational regulator Orb2A tags specific synapses of mushroom body neurons for later consolidation. Consolidation involves the subsequent recruitment of Orb2B and the activity-dependent synthesis of CaMKII
It is NMDA receptor downstream kinase and essential for memory and learning acquisition.(review)
these data support a model in which CaMKII-mediated synapsin phosphorylation in local circuit interneurons induces synaptic vesicle mobilization and thereby presynaptic facilitation of GABA release that underlies olfactory short-term habituation.
Regulated CaMKII autophosphorylation appears essential in central synapse development, and particular cholinergic synapses are affected differentially, although they operate via the same nicotinic receptor.
These results suggest that presynaptic CaMKII activation depends on autophosphorylation and global Ca(2+) in the terminal, while translocation to AZs requires Ca(2+) microdomains generated by IP3Rs.
This study indicated a role for patterned electrical activity and presynaptic calcium signaling, acting through CaMKII, in modulating a retrograde signal during the refinement of synaptic connections.
We found that postsynaptic CaMKII regulates the localization of GluRIIA and GluRIIB, we hypothesize that postsynaptic CaMKII activity monitors the calcium influx through GluRIIA and regulate the amount of synaptic GluRIIA during larval stages
phosphorylates and regulates the eag potassium channel.
PS integrins function upstream of CaMKII in the development of synaptic architecture at the neuromuscular junction.
Regulation of neuronal excitability in Drosophila by constitutively active CaMKII.
This protein was characterized in transgenic animals.
These studies suggest two significant functions of postsynaptic CaMKII in synaptogenesis-retrograde modulation of presynaptic properties and coordinated regulation of pre- and postsynaptic maturation.
Retrograde control of synaptic transmission by postsynaptic CaMKII at the Drosophila neuromuscular junction.
CAMKII is activated by eag potassium channel
The sedative action of diazepam is correlated with selective down-regulation of transcripts involved in regulation of neuronal plasticity and neurotrophic responses. Most transcript changes were transient except for decrease of the CaMKIIalpha transcript
Morphological studies indicate that CaMKII activation in fact reduces postsynaptic sites at 8 h after hatching . This is opposite to the effect observed in larvae just after hatching.
a subpopulation of noncholinergic, nondopaminergic, non-GABAergic neurons can cause CaMKII-dependent reductions in initial courtship, but only cholinergic neurons enhance training-dependent suppression.
CaMKII-induced modulation was independent of the bone morphogenetic protein signaling that is important for retrograde control at mature larvae.
CaMKII is involved in the negative regulation of the visual response affecting light adaptation, possibly by catalyzing phosphorylation of Arr2
A key regulator of plasticity in synaptic physiology and behavior, alterations in its activity produce pleiotrophic effects that involve synaptic transmission and development as well as various aspects of behavior. Directly modulates eag potassium channels.
, CaM kinase
, CaM kinase II
, Ca[2+]/calmodulin-dependent protein kinase II
, Calcium/calmodulin-dependent protein kinase
, calcium/ calmodulin-dependent protein kinase II
, calcium/calmodulin-dependent protein kinase II
, calmodulin kinase II
, calmodulin-dependent kinase
, calmodulin-dependent protein kinase II
, lethal (4) 102EFb
, Ca2+/calmodulin-dependent protein kinase II