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Regulation of molecular clock oscillations and phagocytic activity via muscarinic Ca(2 (show CA2 Proteins)+) signaling in human retinal pigment epithelial cells.
These results indicate that not H1 but M3 receptor-induced activation of p38 MAPK (show MAPK14 Proteins) might contribute to the maintenance of epithelial barrier function through down-regulation of TNF-alpha (show TNF Proteins) signalling and activation of EGFR (show EGFR Proteins).
Morphine-induced MOP receptor (show OPRM1 Proteins) endocytosis is facilitated by concurrent M3 activation.M3 and MOP (show NLN Proteins) assemble in receptor heterocomplexes mainly located at the plasma membrane.M3-MOP receptor (show OPRM1 Proteins) pharmacological interaction is independent of heterocomplex formation.M3 and MOP receptor (show OPRM1 Proteins) heteromers disrupt upon both receptor endocytosis.
this study shows that anti-M3R (show CHRM4 Proteins) is significantly elevated in Sjogren's syndrome plasma in comparison with rheumatoid arthritis, systemic lupus erythematosus, and healthy controls
Interacting post-muscarinic receptor (show CHRM5 Proteins) signaling pathways potentiate MMP1 (show MMP1 Proteins) expression and invasion of human colon cancer cells.
M3R (show CHRM4 Proteins) expression plays an important role in early progression and invasion of colon neoplasia but is less important once tumors have spread.
This study presents the endocytic pathways of internalization for muscarinic type 3 receptor and flotillin-1 (show FLOT1 Proteins)/2 in salivary gland epithelial cells. knockdown of flot-1 (show FLOT1 Proteins) or -2 by flotillin (show FLOT2 Proteins)-specific siRNA prevented internalization and reduced the endocytic efficiency of muscarinic type 3 receptor.
M3-mAChR activation leads to enhancement of hsp expression via PKC (show PRRT2 Proteins)-dependent phosphorylation of HSF1 (show HSF1 Proteins), thereby stabilizing the mutant hERG (show KCNH2 Proteins)-FLAG protein. Thus, M3-mAChR activators may have a therapeutic value for patients with LQT2 (show KCNH2 Proteins).
There were no significant associations between CHRM3 SNPs and autonomic nervous system activity in patients with schizophrenia on high-dose antipsychotics.
To our knowledge, this is the first genetic association study that reveals the genetic contribution of CHRM3 gene in bladder cancer etiology.
Data suggest that both M(2) and M(3) muscarinic receptors mediate the contraction in both pig clasp (show CLASRP Proteins) and sling fibers similar to human clasp (show CLASRP Proteins) and sling fibers.
Sequential activation of muscarinic M3 receptors and cannabinoid CB1 receptors produce synergistic contractile effects of the bovine ciliary muscle by involving the activation of Rho-kinase and protein kinase C.
These data support the existence of a novel transducing cascade, involving Galpha (show SUCLG1 Proteins)(q16)beta gamma coupling M(3)AChR to NPR (show NPTXR Proteins)-GC.
airway M(2)Rs inhibit BK channels by a dual, Gbetagamma-mediated mechanism, a direct membrane-delimited interaction, and the activation of the phospholipase C/protein kinase C pathway
The expression of M3-mAChR was down-regulated in the myocardium from aged mice and D-galactose-treated mice, while the expression levels of caspase-1 (show CASP1 Proteins) and its downstream molecule IL-1beta (show IL1B Proteins) were significantly increased.
Stimulation of the ERK (show EPHB2 Proteins) pathway in Gnb5 (show GNB5 Proteins)(-/-) cells by epidermal growth factor (show EGF Proteins) restored M3R-stimulated insulin (show INS Proteins) release to near normal levels. Identification of the novel role of Gbeta5 (show GNB5 Proteins)-R7 in insulin (show INS Proteins) secretion may lead to a new therapeutic approach for improving pancreatic beta-cell function
s. Moreover, we found that M3 cholinergic receptor (CHRM3) was upregulated in a large subset of benign prostatic hyperplasia (BPH (show GLI3 Proteins)) tissues compared with normal tissues. Activation of CHRM3 also promoted the proliferation of BPH (show GLI3 Proteins) cells.
early intervention with cholinergic receptor muscarinic (ChRM)-3 blocker reversed the progression of airway hyperreactivity in the neonatal exposure model, whereas beta2-adrenoceptor agonists had no such effect
Arthritis-induced joint destruction was significantly stronger in mice with M3 muscarinic acetylcholine receptor deficiency.
The effects of muscarinic receptor (show CHRM5 Proteins) M3 knockout on cathepsin K (show CTSK Proteins) expression, bone density and biomechanical properties of bone are reported.
results suggest that the autoantibodies against peptides of the second extracellular loop of M3R are not pathogenic in vivo and they are not suitable as biomarkers for pSS (show CDSN Proteins) diagnosis
Expression of the M3 receptors mediating cholinergic contractile stimuli of the detrusor muscle was dysregulated in both Mras (show MRAS Proteins)-/- males and females, although only males exhibited a urinary phenotype.
The study screened CrkL (show CRKL Proteins) binding proteins using RNA interference (RNAi) and identified Sorbs1 (show SORBS1 Proteins) and Sorbs2 (show Sorbs2 Proteins) as two proteins that are enriched at AChR clusters and are required for the formation of AChR aggregation in vitro.
Activation of Chrm3 inhibits the recruitment of beta-arrestin-2 (show ARRB2 Proteins) to odorant receptors, resulting in a potentiation of odor-induced responses in olfactory sensory neurons.
G-protein coupled receptor, muscarinic receeptor subtype that mediates cholinergic-induced contraction in most smooth muscle
m3 muscarinic acetylcholine receptor
, muscarinic acetylcholine receptor M3
, cholinergic receptor, muscarinic 3
, acetylcholine receptor, muscarinic 3
, m3 muscarinic receptor
, cholinergic receptor, muscarinic 3, cardiac
, M3 muscarinic acetylcholine receptor
, AChR M3
, mm3 mAChR
, muscarinic acetylcholine receptor 3