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TMEM132D, COMT (show COMT Proteins) and GABRA6 gene polymorphisms may influence susceptibility to panic disorder(PD) and major depressive disorder(MDD)in Japanese adults; these variants may increase vulnerability to PD by modulating oligodendrocytes and GABA and dopaminergic functions in related brain regions, altering neuronal processing of anxiety-related emotional signals
NOS3 (show NANOS3 Proteins), GABRA6, child abuse, neighborhood crime Gene x Gene, Environment x Environment, and Gene x Environment interactions are associated with different patterns of respiratory sinus arrhythmia reactivity.
The gene-gene interaction at two loci involving GABRA6 and Synapsin II (show SYN2 Proteins) revealed a significant association for development of idiopathic generalized epilepsy.
genetic association study in Chinese Han population: Data suggest an SNP in GABRA6 (rs3219151) is associated with decreased predisposition to schizophrenia via alteration of miroRNA binding to target in 3-prime-untranslated region of GABRA6 mRNA.
GABRA6 mutation, R46W, was identified as a susceptibility gene that may contribute to the pathogenesis of childhood absence epilepsy and cause neuronal disinhibition and increase in seizures via a reduction of alphabetagamma and alphabetadelta receptor function and expression
Part of the interindividual differences observed for anxiety traits measured by the Harm Avoidance dimension could be explained by the GABRA6 gene variability.
significant involvement of alpha (GABRA6) and beta (GABRB2 (show GABRB2 Proteins)) subunits of GABA(A) receptor in epilepsy susceptibility in north Indian population
studies have found prefrontal cortical GABA(A) receptor alpha subunit (show POLG Proteins) alterations in schizophrenia
These findings suggest that common variation in the GABRA2 (show GABRA2 Proteins), GABRA3 (show GABRA3 Proteins), GABRA6, and GABRG2 (show GABRG2 Proteins) genes does not play a major role in liability to anxiety spectrum disorders.
These findings support a role for the serotonin transporter (show SLC6A4 Proteins) and GABA(A) alpha6 subunit in depression-related traits.
D3R modulates GABAA receptors function in striatum: chronic blockade of D3R increases alpha6 subunit expression and induces insensitivity to the anxiolytic effect of diazepam
This study demonstrated that Ectopic Expression of alpha6 GABAA (show GABRg1 Proteins) Receptor Subunits in Hilar Somatostatin (show SST Proteins) Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus.
results indicate that in addition to the central role of homologous gamma-aminobutyric acid (GABA) A receptor subunit alpha 6-100R/Q (alpha1-101H) residue in benzodiazepine(BZ) binding this critical BZ binding site has a major impact on BZ binding kinetics
Differential cell surface expression of GABAA (show GABRg1 Proteins) receptor alpha1, alpha6, beta2 and beta3 subunits in cultured mouse cerebellar granule cells influence of cAMP-activated signalling.
GABRA6 expression is regulated by NFI (show NFIC Proteins) in cerebellar granule neurons
Abnormal cerebellar P/Q-type VGCC activity results in a deficit of CGC-specific subtype(s) of GABA(A) receptors which may contribute to, or may be a consequence of the impaired cerebellar network signaling that occurs in cacna1a(tg (show CACNA1A Proteins)) mice.
some aspects of assembly, trafficking, targeting, and/or expression of extrasynaptic alpha6-containing GABA(A) receptors in cerebellar granule cells are selectively regulated by AMPA (show GRIA3 Proteins) receptor-mediated signaling
We tested the hypothesis that homocysteine (Hcy) antagonizes the GABA(A) receptor and behaves as an excitotoxic neurotransmitter that causes blood brain barrier (BBB) permeability and vascular dementia.
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.
gamma-aminobutyric acid receptor subunit alpha-6
, gamma-aminobutyric acid (GABA) A receptor, alpha 6
, gamma-aminobutyric acid A receptor, alpha 6
, gamma-aminobutyric acid receptor subunit alpha-6-like
, GABA(A) receptor subunit alpha-6
, GABA-A receptor alpha-6 subunit
, gamma-aminobutyric acid A receptor, alpha 6
, gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6
, GABA subunit A receptor alpha 6
, GABA(A) receptor, alpha 6
, GABA-A receptor a6 subunit
, gamma-aminobutyric acid A recptor, subunit alpha 6
, subunit alpha 6 gamma-aminobutyric acid (GABA-A) receptor