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|Antigen||Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This GRIN1 antibody is un-conjugated Alternatives|
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
|13 references available|
Product Details anti-GRIN1 AntibodyTarget Details GRIN1 Application Details Handling References for anti-GRIN1 antibody (ABIN152467) Images
|Specificity||Specific for the ~120k NR1 subunit of the NMDA receptor.|
|Purification||Tissue culture supernatant|
|Immunogen||Fusion protein containing amino acids 1-564 of the NR1 subunit of rat NMDA receptor.|
|Plasmids, Primers & others|
Target Details GRIN1Product Details anti-GRIN1 Antibody Application Details Handling References for anti-GRIN1 antibody (ABIN152467) Images back to top
|Alternative Name||NMDAR1 (GRIN1 Antibody Abstract)|
|Background||Gene Symbol: GRIN1|
|Molecular Weight||Theoretical MW: 120 kDa|
|Pathways||Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity|
Application DetailsProduct Details anti-GRIN1 Antibody Target Details GRIN1 Handling References for anti-GRIN1 antibody (ABIN152467) Images back to top
|Application Notes||Western Blot 1:1000, Immunocytochemistry/Immunofluorescence, Immunoprecipitation 3 μg/200 μg lysate, Immunohistochemistry-Paraffin, Immunohistochemistry-FrozenUse in Immunocytochemistry/immunofluorescence and Immunohistochemistry-Frozen reported in scientific literature (PMID: 20414717). Use in Immunohistochemistry-Paraffin reported in scientific literature (PMID 26635527). The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.|
The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.
|Restrictions||For Research Use only|
HandlingProduct Details anti-GRIN1 Antibody Target Details GRIN1 Application Details References for anti-GRIN1 antibody (ABIN152467) Images back to top
|Reconstitution||Reconstitute with 50 μL PBS to desired concentration.|
Buffer contains: No Preservative
|Handling Advice||Avoid freeze-thaw cycles|
|Storage Comment||Store at -20°C. Avoid freeze-thaw cycles.|
References for anti-GRIN1 antibody (ABIN152467)Product Details anti-GRIN1 Antibody Target Details GRIN1 Application Details Handling Images back to top
|Product cited in:||
Stewart, Lau, Banks, Bains, Castroflorio, Oliver, Dixon, Kruer, Kullmann, Acevedo-Arozena, Wells, Corrochano, Nolan: "Loss of Frrs1l disrupts synaptic AMPA receptor function, and results in neurodevelopmental, motor, cognitive and electrographical abnormalities." in: Disease models & mechanisms, Vol. 12, Issue 2, 2019 Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)).
Shi, Hung, Rocha, Lin, Linares, Staats, Seah, Wang, Chickering, Lai, Sugawara, Sagare, Zlokovic, Ichida: "Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons." in: JCI insight, Vol. 5, 2019 Method employed by authors: Western Blotting (WB) (Sample species: Human).
Shi, Lin, Staats, Li, Chang, Hung, Hendricks, Linares, Wang, Son, Wen, Kisler, Wilkinson, Menendez, Sugawara, Woolwine, Huang, Cowan, Ge, Koutsodendris, Sandor, Komberg, Vangoor, Senthilkumar, Hennes et al.: "Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons. ..." in: Nature medicine, Vol. 24, Issue 3, pp. 313-325, 2018
Gorska-Ponikowska, Perricone, Kuban-Jankowska, Lo Bosco, Barone: "2-methoxyestradiol impacts on amino acids-mediated metabolic reprogramming in osteosarcoma cells by its interaction with NMDA receptor." in: Journal of cellular physiology, 2017 Method employed by authors: Western Blotting (WB) (Sample species: Human).
Hewett, Shi, Gong, Dhandapani, Pilbeam, Hewett et al.: "Spontaneous Glutamatergic Synaptic Activity Regulates Constitutive COX-2 Expression in Neurons: OPPOSING ROLES FOR THE TRANSCRIPTION FACTORS CREB (cAMP RESPONSE ELEMENT BINDING) PROTEIN AND Sp1 ..." in: The Journal of biological chemistry, Vol. 291, Issue 53, pp. 27279-27288, 2016 Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)).
Brai, Marathe, Astori, Fredj, Perry, Lamy, Scotti, Alberi: "Notch1 Regulates Hippocampal Plasticity Through Interaction with the Reelin Pathway, Glutamatergic Transmission and CREB Signaling." in: Frontiers in cellular neuroscience, Vol. 9, pp. 447, 2015 (Sample species: Mouse (Murine)). Further details: Immunohistochemistry (Paraffin-embedded Sections)
Plaza-Zabala, Li, Milovanovic, Loweth, Maldonado, Berrendero, Wolf: "An investigation of interactions between hypocretin/orexin signaling and glutamate receptor surface expression in the rat nucleus accumbens under basal conditions and after cocaine exposure." in: Neuroscience letters, Vol. 557 Pt B, pp. 101-6, 2013 (Sample species: Rat (Rattus)). Further details: Western Blotting
Ferrario, Loweth, Milovanovic, Wang, Wolf: "Distribution of AMPA receptor subunits and TARPs in synaptic and extrasynaptic membranes of the adult rat nucleus accumbens." in: Neuroscience letters, Vol. 490, Issue 3, pp. 180-4, 2011 (Sample species: Rat (Rattus)). Further details: Western Blotting
Tao, Chen, Huang: "Dextromethorphan attenuated the higher vulnerability to inflammatory thermal hyperalgesia caused by prenatal morphine exposure in rat offspring." in: Journal of biomedical science, Vol. 18, pp. 64, 2011 (Sample species: Rat (Rattus)). Further details: Western Blotting
Mashkina, Cizkova, Vanicky, Boldyrev: "NMDA receptors are expressed in lymphocytes activated both in vitro and in vivo." in: Cellular and molecular neurobiology, Vol. 30, Issue 6, pp. 901-7, 2010 Further details: Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Frozen Sections)
Garraway, Xu, Inturrisi: "siRNA-mediated knockdown of the NR1 subunit gene of the NMDA receptor attenuates formalin-induced pain behaviors in adult rats." in: The journal of pain : official journal of the American Pain Society, Vol. 10, Issue 4, pp. 380-90, 2009 (Sample species: Rat (Rattus)).
Lim, Wang, Zeng, Sung, Yang, Mao: "Expression of spinal NMDA receptor and PKCgamma after chronic morphine is regulated by spinal glucocorticoid receptor." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 25, Issue 48, pp. 11145-54, 2005 (Sample species: Rat (Rattus)). Further details: Immunocytochemistry,Western Blotting,Immunofluorescence
Nagy, Kolok, Dezso, Boros, Szombathelyi: "Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones." in: Neurochemistry international, Vol. 42, Issue 1, pp. 35-43, 2002
ImagesProduct Details anti-GRIN1 Antibody Target Details GRIN1 Application Details Handling References for anti-GRIN1 antibody (ABIN152467) back to top